Decreased Insulin Sensitivity and Impaired Fibrinolytic Activity in Type 2 Diabetes Patients and Nondiabetics with Ischemic Stroke
We analyzed (a) insulin sensitivity (IS), (b) plasma insulin (PI), and (c) plasminogen activator inhibitor-1 (PAI-1) in type 2 diabetes (T2D) patients with (group A) and without (group B) atherothrombotic ischemic stroke (ATIS), nondiabetics with ATIS (group C), and healthy controls (group D). IS wa...
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| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/934791 |
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| author | Aleksandra Jotic Tanja Milicic Nadezda Covickovic Sternic Vladimir S. Kostic Katarina Lalic Veljko Jeremic Milija Mijajlovic Ljiljana Lukic Natasa Rajkovic Milorad Civcic Marija Macesic Jelena P. Seferovic Jelena Stanarcic Sandra Aleksic Nebojsa M. Lalic |
| author_facet | Aleksandra Jotic Tanja Milicic Nadezda Covickovic Sternic Vladimir S. Kostic Katarina Lalic Veljko Jeremic Milija Mijajlovic Ljiljana Lukic Natasa Rajkovic Milorad Civcic Marija Macesic Jelena P. Seferovic Jelena Stanarcic Sandra Aleksic Nebojsa M. Lalic |
| author_sort | Aleksandra Jotic |
| collection | DOAJ |
| description | We analyzed (a) insulin sensitivity (IS), (b) plasma insulin (PI), and (c) plasminogen activator inhibitor-1 (PAI-1) in type 2 diabetes (T2D) patients with (group A) and without (group B) atherothrombotic ischemic stroke (ATIS), nondiabetics with ATIS (group C), and healthy controls (group D). IS was determined by minimal model (Si). Si was lower in A versus B (1.18±0.67 versus 2.82±0.61 min−1/mU/L × 104; P<0.001) and in C versus D (3.18±0.93 versus 6.13±1.69 min−1/mU/L × 104; P<0.001). PI and PAI-1 were higher in A versus B (PI: 19.61±4.08 versus 14.91±1.66 mU/L; P<0.001, PAI-1: 7.75±1.04 versus 4.57±0.72 mU/L; P<0.001) and in C versus D (PI: 15.14±2.20 versus 7.58±2.05 mU/L; P<0.001, PAI-1: 4.78±0.98 versus 3.49±1.04 mU/L; P<0.001). Si correlated with PAI-1 in T2D patients and nondiabetics, albeit stronger in T2D. Binary logistic regression identified insulin, PAI-1, and Si as independent predictors for ATIS in T2D patients and nondiabetics. The results imply that insulin resistance and fasting hyperinsulinemia might exert their atherogenic impact through the impaired fibrinolysis. |
| format | Article |
| id | doaj-art-93caaa53f09c472ab838683cd188a5ef |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-93caaa53f09c472ab838683cd188a5ef2025-08-20T02:10:11ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/934791934791Decreased Insulin Sensitivity and Impaired Fibrinolytic Activity in Type 2 Diabetes Patients and Nondiabetics with Ischemic StrokeAleksandra Jotic0Tanja Milicic1Nadezda Covickovic Sternic2Vladimir S. Kostic3Katarina Lalic4Veljko Jeremic5Milija Mijajlovic6Ljiljana Lukic7Natasa Rajkovic8Milorad Civcic9Marija Macesic10Jelena P. Seferovic11Jelena Stanarcic12Sandra Aleksic13Nebojsa M. Lalic14Clinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 13, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 13, 11000 Belgrade, SerbiaClinic for Neurology, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 6, 11000 Belgrade, SerbiaClinic for Neurology, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 6, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 13, 11000 Belgrade, SerbiaDepartment for Operations Research and Statistics, Faculty of Organizational Sciences, University of Belgrade, Jove Ilica 154, 11 000 Belgrade, SerbiaClinic for Neurology, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 6, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 13, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 13, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 13, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 13, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 13, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 13, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 13, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 13, 11000 Belgrade, SerbiaWe analyzed (a) insulin sensitivity (IS), (b) plasma insulin (PI), and (c) plasminogen activator inhibitor-1 (PAI-1) in type 2 diabetes (T2D) patients with (group A) and without (group B) atherothrombotic ischemic stroke (ATIS), nondiabetics with ATIS (group C), and healthy controls (group D). IS was determined by minimal model (Si). Si was lower in A versus B (1.18±0.67 versus 2.82±0.61 min−1/mU/L × 104; P<0.001) and in C versus D (3.18±0.93 versus 6.13±1.69 min−1/mU/L × 104; P<0.001). PI and PAI-1 were higher in A versus B (PI: 19.61±4.08 versus 14.91±1.66 mU/L; P<0.001, PAI-1: 7.75±1.04 versus 4.57±0.72 mU/L; P<0.001) and in C versus D (PI: 15.14±2.20 versus 7.58±2.05 mU/L; P<0.001, PAI-1: 4.78±0.98 versus 3.49±1.04 mU/L; P<0.001). Si correlated with PAI-1 in T2D patients and nondiabetics, albeit stronger in T2D. Binary logistic regression identified insulin, PAI-1, and Si as independent predictors for ATIS in T2D patients and nondiabetics. The results imply that insulin resistance and fasting hyperinsulinemia might exert their atherogenic impact through the impaired fibrinolysis.http://dx.doi.org/10.1155/2015/934791 |
| spellingShingle | Aleksandra Jotic Tanja Milicic Nadezda Covickovic Sternic Vladimir S. Kostic Katarina Lalic Veljko Jeremic Milija Mijajlovic Ljiljana Lukic Natasa Rajkovic Milorad Civcic Marija Macesic Jelena P. Seferovic Jelena Stanarcic Sandra Aleksic Nebojsa M. Lalic Decreased Insulin Sensitivity and Impaired Fibrinolytic Activity in Type 2 Diabetes Patients and Nondiabetics with Ischemic Stroke International Journal of Endocrinology |
| title | Decreased Insulin Sensitivity and Impaired Fibrinolytic Activity in Type 2 Diabetes Patients and Nondiabetics with Ischemic Stroke |
| title_full | Decreased Insulin Sensitivity and Impaired Fibrinolytic Activity in Type 2 Diabetes Patients and Nondiabetics with Ischemic Stroke |
| title_fullStr | Decreased Insulin Sensitivity and Impaired Fibrinolytic Activity in Type 2 Diabetes Patients and Nondiabetics with Ischemic Stroke |
| title_full_unstemmed | Decreased Insulin Sensitivity and Impaired Fibrinolytic Activity in Type 2 Diabetes Patients and Nondiabetics with Ischemic Stroke |
| title_short | Decreased Insulin Sensitivity and Impaired Fibrinolytic Activity in Type 2 Diabetes Patients and Nondiabetics with Ischemic Stroke |
| title_sort | decreased insulin sensitivity and impaired fibrinolytic activity in type 2 diabetes patients and nondiabetics with ischemic stroke |
| url | http://dx.doi.org/10.1155/2015/934791 |
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