Effects of intrauterine autologous platelet-rich plasma infusions on outcomes in women with repetitive in vitro fertilization failures: a prospective randomized study
Purpose: Evaluation of the effect of platelet-rich plasma (PRP) containing platelet-derived growth factor on in vitro fertilization (IVF) failure patients. Methods: In this clinical trial, 80 eligible patients (infertile women with at least two IVF failures) were randomly assigned into two groups, i...
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IMR Press
2021-02-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/48/1/10.31083/j.ceog.2021.01.2131 |
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| author | Mahvash Zargar Razieh Pazhouhanfar Mahin Najafian ParastooMoradi Choghakabodi |
| author_facet | Mahvash Zargar Razieh Pazhouhanfar Mahin Najafian ParastooMoradi Choghakabodi |
| author_sort | Mahvash Zargar |
| collection | DOAJ |
| description | Purpose: Evaluation of the effect of platelet-rich plasma (PRP) containing platelet-derived growth factor on in vitro fertilization (IVF) failure patients. Methods: In this clinical trial, 80 eligible patients (infertile women with at least two IVF failures) were randomly assigned into two groups, including patients who received an intrauterine infusion of PRP (n: 40) and controls (n: 40). Before PRP therapy, standard hormone replacement therapy was performed for all patients to endometrial thickness preparation. After sonographic assessment of endometrium, PRP was injected into all patients’ endometrium whether they had an appropriate endometrial thickness or not. Then, the embryo transferring was done through IVF. Eventually, the consequences of fertility, embryo implantation, and pregnancy were evaluated. Data analysis was performed using SPSS version 22. Results: The rate of successful IVF [6 (15%)], pregnancy rate [5 (12.5%)], and live birth [5 (12.5%)] were relatively higher in patients undergoing PRP therapy compared with controls [2 (5%), 1 (2.5%) and 0, respectively]. However, their statistical difference was not significant between the two groups (P > 0.05). Conclusion: Our findings suggest that endometrial injection of platelet-rich plasma for IVF failure patients did not significantly improve the IVF process, pregnancy, and live birth rates. |
| format | Article |
| id | doaj-art-93c90b85a6d14935a85ffba3135ca41e |
| institution | OA Journals |
| issn | 0390-6663 |
| language | English |
| publishDate | 2021-02-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-93c90b85a6d14935a85ffba3135ca41e2025-08-20T02:10:11ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632021-02-0148117918410.31083/j.ceog.2021.01.21311611714514541-1594302871Effects of intrauterine autologous platelet-rich plasma infusions on outcomes in women with repetitive in vitro fertilization failures: a prospective randomized studyMahvash Zargar0Razieh Pazhouhanfar1Mahin Najafian2ParastooMoradi Choghakabodi3Department of Obstetrics and Gynecology, Fertility Infertility and Perinatology Research Center, Ahvaz Jundishapur University of medical sciences, 61357-15794 Ahvaz, IranDepartment of Obstetrics and Gynecology, Fertility Infertility and Perinatology Research Center, Ahvaz Jundishapur University of medical sciences, 61357-15794 Ahvaz, IranDepartment of Obstetrics and Gynecology, Fertility Infertility and Perinatology Research Center, Ahvaz Jundishapur University of medical sciences, 61357-15794 Ahvaz, IranAhvaz Jundishapur University of Medical Sciences; Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, 61357-15794 Ahvaz, IranPurpose: Evaluation of the effect of platelet-rich plasma (PRP) containing platelet-derived growth factor on in vitro fertilization (IVF) failure patients. Methods: In this clinical trial, 80 eligible patients (infertile women with at least two IVF failures) were randomly assigned into two groups, including patients who received an intrauterine infusion of PRP (n: 40) and controls (n: 40). Before PRP therapy, standard hormone replacement therapy was performed for all patients to endometrial thickness preparation. After sonographic assessment of endometrium, PRP was injected into all patients’ endometrium whether they had an appropriate endometrial thickness or not. Then, the embryo transferring was done through IVF. Eventually, the consequences of fertility, embryo implantation, and pregnancy were evaluated. Data analysis was performed using SPSS version 22. Results: The rate of successful IVF [6 (15%)], pregnancy rate [5 (12.5%)], and live birth [5 (12.5%)] were relatively higher in patients undergoing PRP therapy compared with controls [2 (5%), 1 (2.5%) and 0, respectively]. However, their statistical difference was not significant between the two groups (P > 0.05). Conclusion: Our findings suggest that endometrial injection of platelet-rich plasma for IVF failure patients did not significantly improve the IVF process, pregnancy, and live birth rates.https://www.imrpress.com/journal/CEOG/48/1/10.31083/j.ceog.2021.01.2131platelet-rich plasmaplatelet-derived growth factorin vitro fertilizationpregnancy ratelive birthwomen |
| spellingShingle | Mahvash Zargar Razieh Pazhouhanfar Mahin Najafian ParastooMoradi Choghakabodi Effects of intrauterine autologous platelet-rich plasma infusions on outcomes in women with repetitive in vitro fertilization failures: a prospective randomized study Clinical and Experimental Obstetrics & Gynecology platelet-rich plasma platelet-derived growth factor in vitro fertilization pregnancy rate live birth women |
| title | Effects of intrauterine autologous platelet-rich plasma infusions on outcomes in women with repetitive in vitro fertilization failures: a prospective randomized study |
| title_full | Effects of intrauterine autologous platelet-rich plasma infusions on outcomes in women with repetitive in vitro fertilization failures: a prospective randomized study |
| title_fullStr | Effects of intrauterine autologous platelet-rich plasma infusions on outcomes in women with repetitive in vitro fertilization failures: a prospective randomized study |
| title_full_unstemmed | Effects of intrauterine autologous platelet-rich plasma infusions on outcomes in women with repetitive in vitro fertilization failures: a prospective randomized study |
| title_short | Effects of intrauterine autologous platelet-rich plasma infusions on outcomes in women with repetitive in vitro fertilization failures: a prospective randomized study |
| title_sort | effects of intrauterine autologous platelet rich plasma infusions on outcomes in women with repetitive in vitro fertilization failures a prospective randomized study |
| topic | platelet-rich plasma platelet-derived growth factor in vitro fertilization pregnancy rate live birth women |
| url | https://www.imrpress.com/journal/CEOG/48/1/10.31083/j.ceog.2021.01.2131 |
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