Historical perspectives and emerging trends in fentanyl use: Part 2 – overdose and misuse
The misuse of fentanyl and its analogs has significantly worsened the opioid crisis, leading to a sharp increase in overdose fatalities. Fentanyl overdose primarily causes severe respiratory depression, which can result in hypoxia, cardiac arrest, and death, often exacerbated by co-intoxication. Add...
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2025-06-01
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| Series: | Pharmacia |
| Online Access: | https://pharmacia.pensoft.net/article/149215/download/pdf/ |
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| _version_ | 1850222393304285184 |
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| author | Stanila Stoeva-Grigorova Maya Radeva-Ilieva Nadezhda Karkkeselyan Stela Dragomanova Gabriela Kehayova Simeonka Dimitrova Maria Petrova Snezha Zlateva Petko Marinov |
| author_facet | Stanila Stoeva-Grigorova Maya Radeva-Ilieva Nadezhda Karkkeselyan Stela Dragomanova Gabriela Kehayova Simeonka Dimitrova Maria Petrova Snezha Zlateva Petko Marinov |
| author_sort | Stanila Stoeva-Grigorova |
| collection | DOAJ |
| description | The misuse of fentanyl and its analogs has significantly worsened the opioid crisis, leading to a sharp increase in overdose fatalities. Fentanyl overdose primarily causes severe respiratory depression, which can result in hypoxia, cardiac arrest, and death, often exacerbated by co-intoxication. Additionally, the opioid in question can induce chest wall rigidity, further complicating treatment procedures. Despite international control efforts, the drug’s high potency and low cost have fueled its widespread trafficking, including in counterfeit pills. While naloxone is the primary antidote, its effectiveness is limited, highlighting the need for stronger, long-acting treatments. Factors such as polypharmacy, prescription misuse, and environmental exposure – as well as the potential for fentanyl’s use as a chemical weapon – pose significant public safety risks. In conclusion, addressing the current wave of the opioid crisis requires a comprehensive approach, integrating treatment solutions, prevention, and harm reduction strategies. |
| format | Article |
| id | doaj-art-93c705d551d743f29461be7828a1ddcc |
| institution | OA Journals |
| issn | 2603-557X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Pharmacia |
| spelling | doaj-art-93c705d551d743f29461be7828a1ddcc2025-08-20T02:06:22ZengPensoft PublishersPharmacia2603-557X2025-06-017211310.3897/pharmacia.72.e149215149215Historical perspectives and emerging trends in fentanyl use: Part 2 – overdose and misuseStanila Stoeva-Grigorova0Maya Radeva-Ilieva1Nadezhda Karkkeselyan2Stela Dragomanova3Gabriela Kehayova4Simeonka Dimitrova5Maria Petrova6Snezha Zlateva7Petko Marinov8Medical University “Prof. Dr. Paraskev Stoyanov”Medical University “Prof. Dr. Paraskev Stoyanov”Medical University “Prof. Dr. Paraskev Stoyanov”Medical University “Prof. Dr. Paraskev Stoyanov”Medical University “Prof. Dr. Paraskev Stoyanov”Medical University “Prof. Dr. Paraskev Stoyanov”Medical University “Prof. Dr. Paraskev Stoyanov”Medical University “Prof. Dr. Paraskev Stoyanov”Medical University “Prof. Dr. Paraskev Stoyanov”The misuse of fentanyl and its analogs has significantly worsened the opioid crisis, leading to a sharp increase in overdose fatalities. Fentanyl overdose primarily causes severe respiratory depression, which can result in hypoxia, cardiac arrest, and death, often exacerbated by co-intoxication. Additionally, the opioid in question can induce chest wall rigidity, further complicating treatment procedures. Despite international control efforts, the drug’s high potency and low cost have fueled its widespread trafficking, including in counterfeit pills. While naloxone is the primary antidote, its effectiveness is limited, highlighting the need for stronger, long-acting treatments. Factors such as polypharmacy, prescription misuse, and environmental exposure – as well as the potential for fentanyl’s use as a chemical weapon – pose significant public safety risks. In conclusion, addressing the current wave of the opioid crisis requires a comprehensive approach, integrating treatment solutions, prevention, and harm reduction strategies.https://pharmacia.pensoft.net/article/149215/download/pdf/ |
| spellingShingle | Stanila Stoeva-Grigorova Maya Radeva-Ilieva Nadezhda Karkkeselyan Stela Dragomanova Gabriela Kehayova Simeonka Dimitrova Maria Petrova Snezha Zlateva Petko Marinov Historical perspectives and emerging trends in fentanyl use: Part 2 – overdose and misuse Pharmacia |
| title | Historical perspectives and emerging trends in fentanyl use: Part 2 – overdose and misuse |
| title_full | Historical perspectives and emerging trends in fentanyl use: Part 2 – overdose and misuse |
| title_fullStr | Historical perspectives and emerging trends in fentanyl use: Part 2 – overdose and misuse |
| title_full_unstemmed | Historical perspectives and emerging trends in fentanyl use: Part 2 – overdose and misuse |
| title_short | Historical perspectives and emerging trends in fentanyl use: Part 2 – overdose and misuse |
| title_sort | historical perspectives and emerging trends in fentanyl use part 2 overdose and misuse |
| url | https://pharmacia.pensoft.net/article/149215/download/pdf/ |
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