Clinical diagnosis, treatment and prognosis analysis of children with pancreatic tumours
ObjectiveTo investigate the diagnosis, treatment, and prognosis of children with pancreatic tumours.MethodsWe conducted a retrospective review of patients ≤18 years of age with pancreatic neoplasms who underwent surgery at a single institution between 2010 and 2022.ResultsThe most common histology a...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1576273/full |
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| author | Yao Zhang Yao Zhang Yao Zhang Yao Zhang Chao Yang Chao Yang Chao Yang Chao Yang Zhenzhen Zhao Zhenzhen Zhao Zhenzhen Zhao Zhenzhen Zhao |
| author_facet | Yao Zhang Yao Zhang Yao Zhang Yao Zhang Chao Yang Chao Yang Chao Yang Chao Yang Zhenzhen Zhao Zhenzhen Zhao Zhenzhen Zhao Zhenzhen Zhao |
| author_sort | Yao Zhang |
| collection | DOAJ |
| description | ObjectiveTo investigate the diagnosis, treatment, and prognosis of children with pancreatic tumours.MethodsWe conducted a retrospective review of patients ≤18 years of age with pancreatic neoplasms who underwent surgery at a single institution between 2010 and 2022.ResultsThe most common histology among the 48 patients was solid pseudopapillary neoplasm of the pancreas (SPN, n = 32), followed by pancreatic blastoma (PB, n = 12), B-cell lymphoblastic lymphoma (n = 1), leukaemia (n = 1), pancreatic cancer (n = 1), and pancreatic neuroendocrine tumours (n = 1). The tumours were located in the head of the pancreas in 29 patients (10 patients underwent pancreaticoduodenectomy, 9 patients underwent Whipple, 7 patients underwent pancreatic tumour resection, and 3 patients underwent laparoscopic tumour enucleation). The tumours were located in the tail of the pancreatic body in 19 patients (10 patients underwent local resection of the pancreatic tumour, 5 patients underwent resection of the pancreatic body and tail and spleen, 3 patients underwent spleen-preserving distal pancreatectomy, and 1 patient underwent laparoscopic resection of the tumour). Patients with pancreatoblastoma, acute lymphoblastic leukaemia, B lymphoblastic lymphoma or pancreatic cancer were treated with regular chemotherapy. Forty-five patients (93.75%) were currently alive and disease free, and the median follow-up was 8.2 years (IQR: 2.0–14.3). Two patients with pancreatic blastoma died during the follow-up, and 1 patient with pancreatic cancer died due to tumour recurrence and progression after treatment.ConclusionPaediatric pancreatic tumours are highly heterogeneous. Complete surgical resection that preserves organ function is the preferred treatment for children with pancreatic tumours. |
| format | Article |
| id | doaj-art-93c64baab0254c6fa2c9eab5ddc5132d |
| institution | OA Journals |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-93c64baab0254c6fa2c9eab5ddc5132d2025-08-20T02:33:00ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-06-011310.3389/fped.2025.15762731576273Clinical diagnosis, treatment and prognosis analysis of children with pancreatic tumoursYao Zhang0Yao Zhang1Yao Zhang2Yao Zhang3Chao Yang4Chao Yang5Chao Yang6Chao Yang7Zhenzhen Zhao8Zhenzhen Zhao9Zhenzhen Zhao10Zhenzhen Zhao11Department of Surgical Oncology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Chongqing, ChinaMinistry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaInternational Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, ChinaChongqing Municipal Health Commission Key Laboratory of Children’s Vital Organ Development and Diseases, Chongqing, ChinaDepartment of Surgical Oncology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Chongqing, ChinaMinistry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaInternational Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, ChinaChongqing Municipal Health Commission Key Laboratory of Children’s Vital Organ Development and Diseases, Chongqing, ChinaDepartment of Surgical Oncology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Chongqing, ChinaMinistry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaInternational Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, ChinaChongqing Municipal Health Commission Key Laboratory of Children’s Vital Organ Development and Diseases, Chongqing, ChinaObjectiveTo investigate the diagnosis, treatment, and prognosis of children with pancreatic tumours.MethodsWe conducted a retrospective review of patients ≤18 years of age with pancreatic neoplasms who underwent surgery at a single institution between 2010 and 2022.ResultsThe most common histology among the 48 patients was solid pseudopapillary neoplasm of the pancreas (SPN, n = 32), followed by pancreatic blastoma (PB, n = 12), B-cell lymphoblastic lymphoma (n = 1), leukaemia (n = 1), pancreatic cancer (n = 1), and pancreatic neuroendocrine tumours (n = 1). The tumours were located in the head of the pancreas in 29 patients (10 patients underwent pancreaticoduodenectomy, 9 patients underwent Whipple, 7 patients underwent pancreatic tumour resection, and 3 patients underwent laparoscopic tumour enucleation). The tumours were located in the tail of the pancreatic body in 19 patients (10 patients underwent local resection of the pancreatic tumour, 5 patients underwent resection of the pancreatic body and tail and spleen, 3 patients underwent spleen-preserving distal pancreatectomy, and 1 patient underwent laparoscopic resection of the tumour). Patients with pancreatoblastoma, acute lymphoblastic leukaemia, B lymphoblastic lymphoma or pancreatic cancer were treated with regular chemotherapy. Forty-five patients (93.75%) were currently alive and disease free, and the median follow-up was 8.2 years (IQR: 2.0–14.3). Two patients with pancreatic blastoma died during the follow-up, and 1 patient with pancreatic cancer died due to tumour recurrence and progression after treatment.ConclusionPaediatric pancreatic tumours are highly heterogeneous. Complete surgical resection that preserves organ function is the preferred treatment for children with pancreatic tumours.https://www.frontiersin.org/articles/10.3389/fped.2025.1576273/fullpancreatic tumourchildrentreatmentprognosisdiagnosis |
| spellingShingle | Yao Zhang Yao Zhang Yao Zhang Yao Zhang Chao Yang Chao Yang Chao Yang Chao Yang Zhenzhen Zhao Zhenzhen Zhao Zhenzhen Zhao Zhenzhen Zhao Clinical diagnosis, treatment and prognosis analysis of children with pancreatic tumours Frontiers in Pediatrics pancreatic tumour children treatment prognosis diagnosis |
| title | Clinical diagnosis, treatment and prognosis analysis of children with pancreatic tumours |
| title_full | Clinical diagnosis, treatment and prognosis analysis of children with pancreatic tumours |
| title_fullStr | Clinical diagnosis, treatment and prognosis analysis of children with pancreatic tumours |
| title_full_unstemmed | Clinical diagnosis, treatment and prognosis analysis of children with pancreatic tumours |
| title_short | Clinical diagnosis, treatment and prognosis analysis of children with pancreatic tumours |
| title_sort | clinical diagnosis treatment and prognosis analysis of children with pancreatic tumours |
| topic | pancreatic tumour children treatment prognosis diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1576273/full |
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