Lack of Tissue Virological Response as a Predictor of Relapse in Chronic Hepatitis D after Completion Bulevirtide Therapy
Aim: to evaluate the significance of a positive polymerase chain reaction result for hepatitis D virus RNA (HDV RNA) in liver biopsy specimens of patients with chronic hepatitis D (CHD) after completion of antiviral therapy (AVT) as a predictor of infection relapse.Materials and methods. The study i...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2024-12-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1355 |
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| author | P. O. Bogomolov N. A. Shub N. A. Gasilova A. A. Belyakova T. G. Lidzhieva E. A. Kondrasheva N. A. Barsukova M. V. Arapova E. A. Isaeva S. V. Koblov M. V. Kalashnikov O. S. Kuzymina A. Yu. Demyanov A. O. Bueverov I. V. Maev |
| author_facet | P. O. Bogomolov N. A. Shub N. A. Gasilova A. A. Belyakova T. G. Lidzhieva E. A. Kondrasheva N. A. Barsukova M. V. Arapova E. A. Isaeva S. V. Koblov M. V. Kalashnikov O. S. Kuzymina A. Yu. Demyanov A. O. Bueverov I. V. Maev |
| author_sort | P. O. Bogomolov |
| collection | DOAJ |
| description | Aim: to evaluate the significance of a positive polymerase chain reaction result for hepatitis D virus RNA (HDV RNA) in liver biopsy specimens of patients with chronic hepatitis D (CHD) after completion of antiviral therapy (AVT) as a predictor of infection relapse.Materials and methods. The study included 21 patients with CHD who received combined AVT with peginterferon alpha and bulevirtide for 48 weeks, followed by bulevirtide monotherapy for 48–96 weeks, making the total duration of antiviral therapy 96–144 weeks. In all patients HDV RNA became undetectable in serum 24–96 weeks from the start of treatment, with aviremia maintained for at least 48 weeks until the end of AVT. At the end of treatment, all patients underwent liver biopsy to detect HDV RNA in liver tissue.Results. Out of 21 patients with sustained complete virological response (negative polymerase chain reaction result for HDV RNA in serum), 8 (38 %) had HDV RNA detected in liver tissue, indicating that a tissue virological response was not achieved. All 8 patients experienced a relapse of CHD within 24 weeks after discontinuing AVT.Conclusions. In patients with chronic hepatitis D who have achieved a complete virological response in serum, the absence of a virological response in liver tissue (detection of HDV RNA in liver biopsy) is a predictor of relapse, providing a rationale for the continuation of antiviral therapy. |
| format | Article |
| id | doaj-art-93bd69b322bc469fbdc26ae6022e8f8c |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2024-12-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-93bd69b322bc469fbdc26ae6022e8f8c2025-02-10T16:14:40ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732024-12-01345404610.22416/1382-4376-2024-34-5-40-461087Lack of Tissue Virological Response as a Predictor of Relapse in Chronic Hepatitis D after Completion Bulevirtide TherapyP. O. Bogomolov0N. A. Shub1N. A. Gasilova2A. A. Belyakova3T. G. Lidzhieva4E. A. Kondrasheva5N. A. Barsukova6M. V. Arapova7E. A. Isaeva8S. V. Koblov9M. V. Kalashnikov10O. S. Kuzymina11A. Yu. Demyanov12A. O. Bueverov13I. V. Maev14Moscow Regional Research and Clinical Institute (“MONIKI”); Russian University of Medicine; OOO Target Therapy CenterOOO Target Therapy CenterOOO Invitro-MoscowOOO Invitro-MoscowOOO Invitro-MoscowOOO Invitro-MoscowMoscow Regional Research and Clinical Institute (“MONIKI”)OOO Target Therapy CenterMoscow Regional Research and Clinical Institute (“MONIKI”)Moscow Regional Research and Clinical Institute (“MONIKI”)Moscow Regional Research and Clinical Institute (“MONIKI”); I.M. Sechenov First Moscow State Medical University (Sechenov University)Moscow Regional Research and Clinical Institute (“MONIKI”)Moscow Regional Research and Clinical Institute (“MONIKI”)Moscow Regional Research and Clinical Institute (“MONIKI”); I.M. Sechenov First Moscow State Medical University (Sechenov University)Russian University of MedicineAim: to evaluate the significance of a positive polymerase chain reaction result for hepatitis D virus RNA (HDV RNA) in liver biopsy specimens of patients with chronic hepatitis D (CHD) after completion of antiviral therapy (AVT) as a predictor of infection relapse.Materials and methods. The study included 21 patients with CHD who received combined AVT with peginterferon alpha and bulevirtide for 48 weeks, followed by bulevirtide monotherapy for 48–96 weeks, making the total duration of antiviral therapy 96–144 weeks. In all patients HDV RNA became undetectable in serum 24–96 weeks from the start of treatment, with aviremia maintained for at least 48 weeks until the end of AVT. At the end of treatment, all patients underwent liver biopsy to detect HDV RNA in liver tissue.Results. Out of 21 patients with sustained complete virological response (negative polymerase chain reaction result for HDV RNA in serum), 8 (38 %) had HDV RNA detected in liver tissue, indicating that a tissue virological response was not achieved. All 8 patients experienced a relapse of CHD within 24 weeks after discontinuing AVT.Conclusions. In patients with chronic hepatitis D who have achieved a complete virological response in serum, the absence of a virological response in liver tissue (detection of HDV RNA in liver biopsy) is a predictor of relapse, providing a rationale for the continuation of antiviral therapy.https://www.gastro-j.ru/jour/article/view/1355chronic hepatitis dantiviral therapybulevirtideliver biopsycomplete virological responsetissue virological response |
| spellingShingle | P. O. Bogomolov N. A. Shub N. A. Gasilova A. A. Belyakova T. G. Lidzhieva E. A. Kondrasheva N. A. Barsukova M. V. Arapova E. A. Isaeva S. V. Koblov M. V. Kalashnikov O. S. Kuzymina A. Yu. Demyanov A. O. Bueverov I. V. Maev Lack of Tissue Virological Response as a Predictor of Relapse in Chronic Hepatitis D after Completion Bulevirtide Therapy Российский журнал гастроэнтерологии, гепатологии, колопроктологии chronic hepatitis d antiviral therapy bulevirtide liver biopsy complete virological response tissue virological response |
| title | Lack of Tissue Virological Response as a Predictor of Relapse in Chronic Hepatitis D after Completion Bulevirtide Therapy |
| title_full | Lack of Tissue Virological Response as a Predictor of Relapse in Chronic Hepatitis D after Completion Bulevirtide Therapy |
| title_fullStr | Lack of Tissue Virological Response as a Predictor of Relapse in Chronic Hepatitis D after Completion Bulevirtide Therapy |
| title_full_unstemmed | Lack of Tissue Virological Response as a Predictor of Relapse in Chronic Hepatitis D after Completion Bulevirtide Therapy |
| title_short | Lack of Tissue Virological Response as a Predictor of Relapse in Chronic Hepatitis D after Completion Bulevirtide Therapy |
| title_sort | lack of tissue virological response as a predictor of relapse in chronic hepatitis d after completion bulevirtide therapy |
| topic | chronic hepatitis d antiviral therapy bulevirtide liver biopsy complete virological response tissue virological response |
| url | https://www.gastro-j.ru/jour/article/view/1355 |
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