PD-1 induces autophagy via the PI3K/AKT/FoxO1 pathway to promote infectious bursal disease virus replication

PD-1 induces autophagy via the PI3K/AKT/FoxO1 pathway to promote infectious bursal disease virus replication

IntroductionAutophagy is an important process in host cell responses to viral replication and spread, including those against infectious bursal disease virus (IBDV). Programmed death-1 (PD-1) is a known immunoinhibitory receptor, and its expression causes immune dysfunction in B lymphocytes, resulti...

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Bibliographic Details
Main Authors: Qiuyu Zhang, Feng Yue, Guopeng Sun, Liwei Jiang, Peng Li, Yanping Zhu, Zhike Liu, Yangzhao Zhu, Ruiyan Niu, Hua He, Zilong Sun, Xuannian Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
infectious bursal disease virus
PD-1
autophagy
PI3K/AKT
FoxO1
viral replication
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1585012/full
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