Ancestral [Fe-S] biogenesis system SMS has a unique mechanism of cluster assembly and sulfur utilization.

Ancestral [Fe-S] biogenesis system SMS has a unique mechanism of cluster assembly and sulfur utilization.

[Fe-S] clusters are ancient and ubiquitous protein co-factors, which contributed to the emergence of life in an anoxic planet. We have recently identified two minimal [Fe-S] biogenesis systems, MIS and SMS, inferred to be ancestral systems dating back to the Last Universal Common Ancestor and which...

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Main Authors: Macha Dussouchaud, Markel Martinez-Carranza, Pierre-Simon Garcia, Martin Clémancey, Geneviève Blondin, Jean Michel Betton, Ahmed Haouz, Simonetta Gribaldo, Sandrine Ollagnier de Choudens, Ludovic Sauguet, Ariel Mechaly, Frédéric Barras
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-06-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3003223
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