Flexible ureteroscopy combined with potassium sodium hydrogen citrate(PSHC) intervention improves the stone-free rate(SFR) for 20–30 mm uric acid renal stones
Abstract Objective To evaluate the efficacy and safety of combining flexible ureteroscopy (FURS) with potassium sodium hydrogen citrate(PSHC) for the treatment of 20–30 mm uric acid renal stones. Methods A retrospective analysis of outcomes of patients with 20–30 mm uric acid renal stones who were t...
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BMC
2025-02-01
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| Series: | BMC Urology |
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| Online Access: | https://doi.org/10.1186/s12894-025-01710-0 |
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| author | Ru Huang Min-jun Jiang Jian-chun Chen Zhi-jun Cao Zhen-fan Wang Zheng Ma Guo-bing Lin Chen Xu |
| author_facet | Ru Huang Min-jun Jiang Jian-chun Chen Zhi-jun Cao Zhen-fan Wang Zheng Ma Guo-bing Lin Chen Xu |
| author_sort | Ru Huang |
| collection | DOAJ |
| description | Abstract Objective To evaluate the efficacy and safety of combining flexible ureteroscopy (FURS) with potassium sodium hydrogen citrate(PSHC) for the treatment of 20–30 mm uric acid renal stones. Methods A retrospective analysis of outcomes of patients with 20–30 mm uric acid renal stones who were treated with FURS and holmium lithotripsy was conducted between July 2021 and May 2024. Of them, 60 patients accepted FURS combined potassium sodium hydrogen citrate(PSHC) therapy while 70 patients underwent the FURS procedure alone. The demographic data, stone characteristics, surgical details, and perioperative outcomes of the patients were assessed retrospectively. Stone-free status was defined as the complete absence of stones on computed tomography. Results Totally 130 patients were enrolled and analyzed in this study. No significant differences were found between the two groups in terms of gender, age, body mass index, comorbidities, stone burden, stone density, number of stones, or laterality. The mean operation time, American Society of Anesthesiologists (ASA) score, postoperative stay, and complication rate were also similar between the groups. The combined group incurred higher costs (p < 0.01),but it achieved significantly higher stone-free rate and Wisconsin Stone Quality of Life Questionnaire score at 4 weeks post-operatively (96.7% vs. 85.7%,p = 0.029;124.63 vs. 114.44,p < 0.01). Additionally, the combined group had a significantly higher urine pH at 4 weeks postoperatively compared to the non-combined group (6.63 vs. 5.50, p < 0.01). Conclusion Compared to a single procedure, FURS combined with PSHC therapy is an effective and safe treatment for 20–30 mm uric acid renal stones. |
| format | Article |
| id | doaj-art-93afc27f51494ea18c5b92aaa046ef51 |
| institution | DOAJ |
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| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
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| series | BMC Urology |
| spelling | doaj-art-93afc27f51494ea18c5b92aaa046ef512025-08-20T02:48:33ZengBMCBMC Urology1471-24902025-02-012511710.1186/s12894-025-01710-0Flexible ureteroscopy combined with potassium sodium hydrogen citrate(PSHC) intervention improves the stone-free rate(SFR) for 20–30 mm uric acid renal stonesRu Huang0Min-jun Jiang1Jian-chun Chen2Zhi-jun Cao3Zhen-fan Wang4Zheng Ma5Guo-bing Lin6Chen Xu7Department of Urology, Suzhou Ninth Hospital Affiliated to Soochow UniversityDepartment of Urology, Suzhou Ninth Hospital Affiliated to Soochow UniversityDepartment of Urology, Suzhou Ninth Hospital Affiliated to Soochow UniversityDepartment of Urology, Suzhou Ninth Hospital Affiliated to Soochow UniversityDepartment of Urology, Suzhou Ninth Hospital Affiliated to Soochow UniversityDepartment of Urology, Suzhou Ninth Hospital Affiliated to Soochow UniversityDepartment of Urology, The First Affiliated Hospital of Zhejiang Chinese Medicine UniversityDepartment of Urology, Suzhou Ninth Hospital Affiliated to Soochow UniversityAbstract Objective To evaluate the efficacy and safety of combining flexible ureteroscopy (FURS) with potassium sodium hydrogen citrate(PSHC) for the treatment of 20–30 mm uric acid renal stones. Methods A retrospective analysis of outcomes of patients with 20–30 mm uric acid renal stones who were treated with FURS and holmium lithotripsy was conducted between July 2021 and May 2024. Of them, 60 patients accepted FURS combined potassium sodium hydrogen citrate(PSHC) therapy while 70 patients underwent the FURS procedure alone. The demographic data, stone characteristics, surgical details, and perioperative outcomes of the patients were assessed retrospectively. Stone-free status was defined as the complete absence of stones on computed tomography. Results Totally 130 patients were enrolled and analyzed in this study. No significant differences were found between the two groups in terms of gender, age, body mass index, comorbidities, stone burden, stone density, number of stones, or laterality. The mean operation time, American Society of Anesthesiologists (ASA) score, postoperative stay, and complication rate were also similar between the groups. The combined group incurred higher costs (p < 0.01),but it achieved significantly higher stone-free rate and Wisconsin Stone Quality of Life Questionnaire score at 4 weeks post-operatively (96.7% vs. 85.7%,p = 0.029;124.63 vs. 114.44,p < 0.01). Additionally, the combined group had a significantly higher urine pH at 4 weeks postoperatively compared to the non-combined group (6.63 vs. 5.50, p < 0.01). Conclusion Compared to a single procedure, FURS combined with PSHC therapy is an effective and safe treatment for 20–30 mm uric acid renal stones.https://doi.org/10.1186/s12894-025-01710-0FURSUric acid stonesOral therapyPSHC |
| spellingShingle | Ru Huang Min-jun Jiang Jian-chun Chen Zhi-jun Cao Zhen-fan Wang Zheng Ma Guo-bing Lin Chen Xu Flexible ureteroscopy combined with potassium sodium hydrogen citrate(PSHC) intervention improves the stone-free rate(SFR) for 20–30 mm uric acid renal stones BMC Urology FURS Uric acid stones Oral therapy PSHC |
| title | Flexible ureteroscopy combined with potassium sodium hydrogen citrate(PSHC) intervention improves the stone-free rate(SFR) for 20–30 mm uric acid renal stones |
| title_full | Flexible ureteroscopy combined with potassium sodium hydrogen citrate(PSHC) intervention improves the stone-free rate(SFR) for 20–30 mm uric acid renal stones |
| title_fullStr | Flexible ureteroscopy combined with potassium sodium hydrogen citrate(PSHC) intervention improves the stone-free rate(SFR) for 20–30 mm uric acid renal stones |
| title_full_unstemmed | Flexible ureteroscopy combined with potassium sodium hydrogen citrate(PSHC) intervention improves the stone-free rate(SFR) for 20–30 mm uric acid renal stones |
| title_short | Flexible ureteroscopy combined with potassium sodium hydrogen citrate(PSHC) intervention improves the stone-free rate(SFR) for 20–30 mm uric acid renal stones |
| title_sort | flexible ureteroscopy combined with potassium sodium hydrogen citrate pshc intervention improves the stone free rate sfr for 20 30 mm uric acid renal stones |
| topic | FURS Uric acid stones Oral therapy PSHC |
| url | https://doi.org/10.1186/s12894-025-01710-0 |
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