Declining trend of HTLV-1 among organ/ tissue donors in Iranian Tissue Bank between 2014–2021
Abstract Background Human T-cell Lymphotropic Virus type-1 (HTLV-1) infection is associated with serious disorders, including Adult T-cell Leukemia/Lymphoma (ATLL) and HTLV-1–associated myelopathy/tropical spastic paraparesis (HAM/TSP). In addition to sexual, vertical, parenteral, and blood transfus...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-12-01
|
| Series: | Retrovirology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12977-024-00656-9 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850254068089356288 |
|---|---|
| author | Arash Letafati Sayed Hamidreza Mozhgani Mehdi Norouzi Amir Aboofazeli Zahra Taghiabadi Negar Zafarian Saba Seyedi Elnaz Mohammad Jaberi Sedigheh Poursaleh Maryam Karami Sheida Sarrafzadeh Ahmadreza Sadeghi |
| author_facet | Arash Letafati Sayed Hamidreza Mozhgani Mehdi Norouzi Amir Aboofazeli Zahra Taghiabadi Negar Zafarian Saba Seyedi Elnaz Mohammad Jaberi Sedigheh Poursaleh Maryam Karami Sheida Sarrafzadeh Ahmadreza Sadeghi |
| author_sort | Arash Letafati |
| collection | DOAJ |
| description | Abstract Background Human T-cell Lymphotropic Virus type-1 (HTLV-1) infection is associated with serious disorders, including Adult T-cell Leukemia/Lymphoma (ATLL) and HTLV-1–associated myelopathy/tropical spastic paraparesis (HAM/TSP). In addition to sexual, vertical, parenteral, and blood transfusion, organ/tissue transplantation is considered as a transmission route of HTLV infection. Given the substantial risk of HTLV-1 transmission and the subsequent development of HAM/TSP (approximately 40%) in kidney transplant recipients, pre-transplant donor screening is crucial. The present study aimed to investigate the prevalence of HTLV-1 in potential organ/tissue donors referred to the Iranian Tissue Bank and Research Center (ITBRC). Materials and methods The study population was potential organ and/or tissue donors referred to ITBRC between 2014 and 2021, including two groups of brain death (potential donors of organs and/or tissues) and circulatory death donors (potential tissue donors from Iranian Legal Medicine Organization). Initial screening was performed using enzyme-linked immunosorbent assay (ELISA), and positive cases were confirmed for HTLV-1 infection with polymerase chain reaction (PCR). Results 111 out of 3,814 donors were positive for HTLV-1 (3%). The rate of positive tests between 2014 and 2017 was 6%, which was significantly higher than the positive tests percentage between 2017 and 2021 with 0.5% (P-value < 0.001). The rate of test positivity in females was 4% compared to 2% in males (P-value = 0.001). Furthermore, individuals diagnosed with brain death exhibited a significantly lower likelihood of HTLV-1 infection (0.2%) compared to cases with circulatory death (4%) (P-value < 0.001). Conclusion Considering the contraindication of organ/tissue donation from donors with HTLV-1 positive test, these findings give an insight into the prevalence of HTLV-1 among potential organ/tissue donors in Iran. Moreover, the higher prevalence of HTLV-1 infection in circulatory death donors from Iranian Legal Medicine Organization urges for cautious evaluation in these donors. |
| format | Article |
| id | doaj-art-93ac76e4aab64d73be0348a24ec0c0f4 |
| institution | OA Journals |
| issn | 1742-4690 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Retrovirology |
| spelling | doaj-art-93ac76e4aab64d73be0348a24ec0c0f42025-08-20T01:57:12ZengBMCRetrovirology1742-46902024-12-012111510.1186/s12977-024-00656-9Declining trend of HTLV-1 among organ/ tissue donors in Iranian Tissue Bank between 2014–2021Arash Letafati0Sayed Hamidreza Mozhgani1Mehdi Norouzi2Amir Aboofazeli3Zahra Taghiabadi4Negar Zafarian5Saba Seyedi6Elnaz Mohammad Jaberi7Sedigheh Poursaleh8Maryam Karami9Sheida Sarrafzadeh10Ahmadreza Sadeghi11Department of Virology, School of Public Health, Tehran University of Medical SciencesDepartment of Microbiology and Virology, School of Public Health, Alborz University of Medical SciencesDepartment of Virology, School of Public Health, Tehran University of Medical SciencesResearch Center for Clinical Virology, Tehran University of Medical ScienceResearch Center for Clinical Virology, Tehran University of Medical ScienceResearch Center for Clinical Virology, Tehran University of Medical ScienceResearch Center for Clinical Virology, Tehran University of Medical ScienceResearch Center for Clinical Virology, Tehran University of Medical ScienceIranian Tissue Bank and Research Center, Tehran University of Medical SciencesIranian Tissue Bank and Research Center, Tehran University of Medical SciencesResearch Center for Clinical Virology, Tehran University of Medical ScienceIranian Tissue Bank and Research Center, Tehran University of Medical SciencesAbstract Background Human T-cell Lymphotropic Virus type-1 (HTLV-1) infection is associated with serious disorders, including Adult T-cell Leukemia/Lymphoma (ATLL) and HTLV-1–associated myelopathy/tropical spastic paraparesis (HAM/TSP). In addition to sexual, vertical, parenteral, and blood transfusion, organ/tissue transplantation is considered as a transmission route of HTLV infection. Given the substantial risk of HTLV-1 transmission and the subsequent development of HAM/TSP (approximately 40%) in kidney transplant recipients, pre-transplant donor screening is crucial. The present study aimed to investigate the prevalence of HTLV-1 in potential organ/tissue donors referred to the Iranian Tissue Bank and Research Center (ITBRC). Materials and methods The study population was potential organ and/or tissue donors referred to ITBRC between 2014 and 2021, including two groups of brain death (potential donors of organs and/or tissues) and circulatory death donors (potential tissue donors from Iranian Legal Medicine Organization). Initial screening was performed using enzyme-linked immunosorbent assay (ELISA), and positive cases were confirmed for HTLV-1 infection with polymerase chain reaction (PCR). Results 111 out of 3,814 donors were positive for HTLV-1 (3%). The rate of positive tests between 2014 and 2017 was 6%, which was significantly higher than the positive tests percentage between 2017 and 2021 with 0.5% (P-value < 0.001). The rate of test positivity in females was 4% compared to 2% in males (P-value = 0.001). Furthermore, individuals diagnosed with brain death exhibited a significantly lower likelihood of HTLV-1 infection (0.2%) compared to cases with circulatory death (4%) (P-value < 0.001). Conclusion Considering the contraindication of organ/tissue donation from donors with HTLV-1 positive test, these findings give an insight into the prevalence of HTLV-1 among potential organ/tissue donors in Iran. Moreover, the higher prevalence of HTLV-1 infection in circulatory death donors from Iranian Legal Medicine Organization urges for cautious evaluation in these donors.https://doi.org/10.1186/s12977-024-00656-9Organ transplantationHTLV-1TissueBrain deathCirculatory death |
| spellingShingle | Arash Letafati Sayed Hamidreza Mozhgani Mehdi Norouzi Amir Aboofazeli Zahra Taghiabadi Negar Zafarian Saba Seyedi Elnaz Mohammad Jaberi Sedigheh Poursaleh Maryam Karami Sheida Sarrafzadeh Ahmadreza Sadeghi Declining trend of HTLV-1 among organ/ tissue donors in Iranian Tissue Bank between 2014–2021 Retrovirology Organ transplantation HTLV-1 Tissue Brain death Circulatory death |
| title | Declining trend of HTLV-1 among organ/ tissue donors in Iranian Tissue Bank between 2014–2021 |
| title_full | Declining trend of HTLV-1 among organ/ tissue donors in Iranian Tissue Bank between 2014–2021 |
| title_fullStr | Declining trend of HTLV-1 among organ/ tissue donors in Iranian Tissue Bank between 2014–2021 |
| title_full_unstemmed | Declining trend of HTLV-1 among organ/ tissue donors in Iranian Tissue Bank between 2014–2021 |
| title_short | Declining trend of HTLV-1 among organ/ tissue donors in Iranian Tissue Bank between 2014–2021 |
| title_sort | declining trend of htlv 1 among organ tissue donors in iranian tissue bank between 2014 2021 |
| topic | Organ transplantation HTLV-1 Tissue Brain death Circulatory death |
| url | https://doi.org/10.1186/s12977-024-00656-9 |
| work_keys_str_mv | AT arashletafati decliningtrendofhtlv1amongorgantissuedonorsiniraniantissuebankbetween20142021 AT sayedhamidrezamozhgani decliningtrendofhtlv1amongorgantissuedonorsiniraniantissuebankbetween20142021 AT mehdinorouzi decliningtrendofhtlv1amongorgantissuedonorsiniraniantissuebankbetween20142021 AT amiraboofazeli decliningtrendofhtlv1amongorgantissuedonorsiniraniantissuebankbetween20142021 AT zahrataghiabadi decliningtrendofhtlv1amongorgantissuedonorsiniraniantissuebankbetween20142021 AT negarzafarian decliningtrendofhtlv1amongorgantissuedonorsiniraniantissuebankbetween20142021 AT sabaseyedi decliningtrendofhtlv1amongorgantissuedonorsiniraniantissuebankbetween20142021 AT elnazmohammadjaberi decliningtrendofhtlv1amongorgantissuedonorsiniraniantissuebankbetween20142021 AT sedighehpoursaleh decliningtrendofhtlv1amongorgantissuedonorsiniraniantissuebankbetween20142021 AT maryamkarami decliningtrendofhtlv1amongorgantissuedonorsiniraniantissuebankbetween20142021 AT sheidasarrafzadeh decliningtrendofhtlv1amongorgantissuedonorsiniraniantissuebankbetween20142021 AT ahmadrezasadeghi decliningtrendofhtlv1amongorgantissuedonorsiniraniantissuebankbetween20142021 |