Canadian real-world study of access and clinical results using dupilumab for chronic rhinosinusitis with polyps
Abstract Background Dupilumab is the first monoclonal antibody therapy to be approved in Canada for the treatment of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). The goal of the study was to assess its effectiveness and efficacy in a real-world setting. This study aims to assess how clinical o...
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SAGE Publishing
2022-04-01
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| Series: | Journal of Otolaryngology - Head and Neck Surgery |
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| Online Access: | https://doi.org/10.1186/s40463-022-00570-0 |
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| author | Shaun J. Kilty Andrea Lasso |
| author_facet | Shaun J. Kilty Andrea Lasso |
| author_sort | Shaun J. Kilty |
| collection | DOAJ |
| description | Abstract Background Dupilumab is the first monoclonal antibody therapy to be approved in Canada for the treatment of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). The goal of the study was to assess its effectiveness and efficacy in a real-world setting. This study aims to assess how clinical outcomes of biologic therapy in real-world application (effectiveness) correspond to outcomes in clinical trials (efficacy) and to look into factors that might explain an efficacy-effectiveness gap. Methods A retrospective study evaluating disease specific sinonasal outcomes routinely collected for clinical care. This study included patients who were evaluated for coverage of dupilumab at a tertiary care rhinology clinic for the treatment of CRSwNP in the first year since dupilumab was approved in Canada for this indication. Sinonasal outcomes were be evaluated by collecting data on the Sino-Nasal Outcome Test (SNOT)-22 questionnaire. Results Eighty-five patients were considered for dupilumab therapy during the study period, 49% patients were able to attain coverage for the requested therapy. The mean SNOT-22 score at baseline was 60.56 (SD 21.63). After 16 weeks of treatment the mean SNOT-22 score decreased by 37 points to 23.36; at 28 weeks the mean SNOT-22 was 23.47. After 1 year, the mean SNOT-22 score was 14.37. Conclusion Patients treated with dupilumab for CRSwNP at out tertiary rhinology clinic showed substantial clinical symptom improvement that is similar to that observed in prior randomised clinical trials. No serious adverse effects related to dupilumab were reported in this cohort. Long-term follow-up is needed to inform effectiveness analyses beyond the 1 year clinical trial duration. Graphical Abstract |
| format | Article |
| id | doaj-art-93ac3d5b09dd473f91bc529088dec9ad |
| institution | Kabale University |
| issn | 1916-0216 |
| language | English |
| publishDate | 2022-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Otolaryngology - Head and Neck Surgery |
| spelling | doaj-art-93ac3d5b09dd473f91bc529088dec9ad2025-02-03T00:22:58ZengSAGE PublishingJournal of Otolaryngology - Head and Neck Surgery1916-02162022-04-015111710.1186/s40463-022-00570-0Canadian real-world study of access and clinical results using dupilumab for chronic rhinosinusitis with polypsShaun J. Kilty0Andrea Lasso1Department of Otolaryngology-Head and Neck Surgery, University of Ottawa, The Ottawa HospitalDepartment of Otolaryngology-Head and Neck Surgery, University of Ottawa, The Ottawa HospitalAbstract Background Dupilumab is the first monoclonal antibody therapy to be approved in Canada for the treatment of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). The goal of the study was to assess its effectiveness and efficacy in a real-world setting. This study aims to assess how clinical outcomes of biologic therapy in real-world application (effectiveness) correspond to outcomes in clinical trials (efficacy) and to look into factors that might explain an efficacy-effectiveness gap. Methods A retrospective study evaluating disease specific sinonasal outcomes routinely collected for clinical care. This study included patients who were evaluated for coverage of dupilumab at a tertiary care rhinology clinic for the treatment of CRSwNP in the first year since dupilumab was approved in Canada for this indication. Sinonasal outcomes were be evaluated by collecting data on the Sino-Nasal Outcome Test (SNOT)-22 questionnaire. Results Eighty-five patients were considered for dupilumab therapy during the study period, 49% patients were able to attain coverage for the requested therapy. The mean SNOT-22 score at baseline was 60.56 (SD 21.63). After 16 weeks of treatment the mean SNOT-22 score decreased by 37 points to 23.36; at 28 weeks the mean SNOT-22 was 23.47. After 1 year, the mean SNOT-22 score was 14.37. Conclusion Patients treated with dupilumab for CRSwNP at out tertiary rhinology clinic showed substantial clinical symptom improvement that is similar to that observed in prior randomised clinical trials. No serious adverse effects related to dupilumab were reported in this cohort. Long-term follow-up is needed to inform effectiveness analyses beyond the 1 year clinical trial duration. Graphical Abstracthttps://doi.org/10.1186/s40463-022-00570-0Monoclonal antibodyDupilumabChronic rhinosinusitisNasal polyps |
| spellingShingle | Shaun J. Kilty Andrea Lasso Canadian real-world study of access and clinical results using dupilumab for chronic rhinosinusitis with polyps Journal of Otolaryngology - Head and Neck Surgery Monoclonal antibody Dupilumab Chronic rhinosinusitis Nasal polyps |
| title | Canadian real-world study of access and clinical results using dupilumab for chronic rhinosinusitis with polyps |
| title_full | Canadian real-world study of access and clinical results using dupilumab for chronic rhinosinusitis with polyps |
| title_fullStr | Canadian real-world study of access and clinical results using dupilumab for chronic rhinosinusitis with polyps |
| title_full_unstemmed | Canadian real-world study of access and clinical results using dupilumab for chronic rhinosinusitis with polyps |
| title_short | Canadian real-world study of access and clinical results using dupilumab for chronic rhinosinusitis with polyps |
| title_sort | canadian real world study of access and clinical results using dupilumab for chronic rhinosinusitis with polyps |
| topic | Monoclonal antibody Dupilumab Chronic rhinosinusitis Nasal polyps |
| url | https://doi.org/10.1186/s40463-022-00570-0 |
| work_keys_str_mv | AT shaunjkilty canadianrealworldstudyofaccessandclinicalresultsusingdupilumabforchronicrhinosinusitiswithpolyps AT andrealasso canadianrealworldstudyofaccessandclinicalresultsusingdupilumabforchronicrhinosinusitiswithpolyps |