Effect of adjunctive amoxicillin/metronidazole treatment on subgingival Tannerella forsythia, Prevotella intermedia and Fusobacterium nucleatum recolonization in periodontitis patients
Background: The use of antibiotics adjunctive to non-surgical periodontal treatment is an accepted approach in the treatment of periodontitis. However, bacterial recolonization is a major drawback which complicates the maintenance of therapeutic acquisitions. The aim of this study was to evaluate th...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
2019-08-01
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| Series: | Selcuk Dental Journal |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/download/article-file/892014 |
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| Summary: | Background: The use of antibiotics adjunctive to non-surgical
periodontal treatment is an accepted approach in the treatment of
periodontitis. However, bacterial recolonization is a major drawback which complicates
the maintenance of therapeutic acquisitions. The aim of this study was to
evaluate the clinical and microbiological effects of adjunctive amoxicillin and
metronidazole combination in the treatment of periodontitis during 6 months
follow-up.Methods: Twenty-two periodontitis patients were assigned as
test (n=12) and control (n=10) groups. While test group received amoxicillin
and metronidazole combination as an adjunct to scaling and root planing,
control group treated with scaling and root planing alone. Clinical
examinations and subgingival dental plaque sampling were conducted at baseline
and 1, 3 and 6. months during the follow-up. Fusobacterium nucleatum, Tannerella forsythia and Prevotella intermedia levels were
determined using real time polymerase chain reaction method.Results: Both groups exhibited significant improvements in
each follow-up period when compared to baseline. However, clinical improvements
in test group were more prominent than control group as 3rd and 6th
months. While some decrease was notable in the counts of all investigated bacteria
in both groups, only T. forsythia
levels significantly reduced at all follow-up months in test group comparing
with controls.Conclusions: The results of this study indicated that
amoxicillin/metronidazole treatment adjunctive to scaling and root planing
provided additional clinical benefits and suppressed the T. forsythia recolonization.Keywords: periodontitis; amoxicillin; metronidazole; Real-Time
PCR |
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| ISSN: | 2148-7529 |