Selenium-enriched and ordinary green tea extracts prevent high blood pressure and alter gut microbiota composition of hypertensive rats caused by high-salt diet
High-salt diet is well recognized as a risk factor for hypertension, and dietary intervention plays a critical role in the prevention of hypertension. The current study investigated the effects of selenium-enriched green tea (Se-GT) and ordinary green tea (GT) on prevention of hypertension of rats i...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tsinghua University Press
2022-05-01
|
| Series: | Food Science and Human Wellness |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453021001592 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832557390836269056 |
|---|---|
| author | Meirong Wu Xiaobin Wu Jiangxiong Zhu Fanglan Li Xinlin Wei Yuanfeng Wang |
| author_facet | Meirong Wu Xiaobin Wu Jiangxiong Zhu Fanglan Li Xinlin Wei Yuanfeng Wang |
| author_sort | Meirong Wu |
| collection | DOAJ |
| description | High-salt diet is well recognized as a risk factor for hypertension, and dietary intervention plays a critical role in the prevention of hypertension. The current study investigated the effects of selenium-enriched green tea (Se-GT) and ordinary green tea (GT) on prevention of hypertension of rats induced by high-salt diet, as well as their potential regulatory and mechanism. Our results showed that GT and Se-GT supplementations significantly prevented the increase of blood pressure (BP), activated the phosphoinosmde-3-kinase/protein kinase B (PI3K/Akt) signaling pathway, and regulated the gene expression related to BP, as well as improved the tissue damage like heart, liver, and kidneys. Besides, the key parameters associated with oxidative stress, inflammation and endothelial dysfunction were also altered by GT and Se-GT treatments. Importantly, GT or Se-GT administration adjusted the diversity and composition of the intestinal flora. Moreover, GT and Se-GT supplementations increased the abundance of beneficial bacteria and reduced the abundance of harmful or conditional pathogenic bacteria. More specifically, GT intake specifically and significantly enriched the relative abundance of Paraprevotella and Bacteroides, whereas Se-GT was characterized by specific and significant enrichment for Allobaculum and Bifidobacterium. Our results proved that dietary supplement of GT and Se-GT remarkably improved the vascular functions and effectively prevented tissue damage by regulation of intestinal flora, and thus preventing hypertension induced by high-salt diet. |
| format | Article |
| id | doaj-art-9398de52f3014f58a8f0044f826f2b74 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2022-05-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-9398de52f3014f58a8f0044f826f2b742025-02-03T05:14:30ZengTsinghua University PressFood Science and Human Wellness2213-45302022-05-01113738751Selenium-enriched and ordinary green tea extracts prevent high blood pressure and alter gut microbiota composition of hypertensive rats caused by high-salt dietMeirong Wu0Xiaobin Wu1Jiangxiong Zhu2Fanglan Li3Xinlin Wei4Yuanfeng Wang5Development Center of Plant Germplasm Resources, College of Life Sciences, Shanghai Normal University, Shanghai 200234, ChinaDevelopment Center of Plant Germplasm Resources, College of Life Sciences, Shanghai Normal University, Shanghai 200234, ChinaDevelopment Center of Plant Germplasm Resources, College of Life Sciences, Shanghai Normal University, Shanghai 200234, ChinaDevelopment Center of Plant Germplasm Resources, College of Life Sciences, Shanghai Normal University, Shanghai 200234, ChinaDepartment of Food Science & Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China; Corresponding authors.Development Center of Plant Germplasm Resources, College of Life Sciences, Shanghai Normal University, Shanghai 200234, China; Corresponding authors.High-salt diet is well recognized as a risk factor for hypertension, and dietary intervention plays a critical role in the prevention of hypertension. The current study investigated the effects of selenium-enriched green tea (Se-GT) and ordinary green tea (GT) on prevention of hypertension of rats induced by high-salt diet, as well as their potential regulatory and mechanism. Our results showed that GT and Se-GT supplementations significantly prevented the increase of blood pressure (BP), activated the phosphoinosmde-3-kinase/protein kinase B (PI3K/Akt) signaling pathway, and regulated the gene expression related to BP, as well as improved the tissue damage like heart, liver, and kidneys. Besides, the key parameters associated with oxidative stress, inflammation and endothelial dysfunction were also altered by GT and Se-GT treatments. Importantly, GT or Se-GT administration adjusted the diversity and composition of the intestinal flora. Moreover, GT and Se-GT supplementations increased the abundance of beneficial bacteria and reduced the abundance of harmful or conditional pathogenic bacteria. More specifically, GT intake specifically and significantly enriched the relative abundance of Paraprevotella and Bacteroides, whereas Se-GT was characterized by specific and significant enrichment for Allobaculum and Bifidobacterium. Our results proved that dietary supplement of GT and Se-GT remarkably improved the vascular functions and effectively prevented tissue damage by regulation of intestinal flora, and thus preventing hypertension induced by high-salt diet.http://www.sciencedirect.com/science/article/pii/S2213453021001592High-salt dietHypertensionGreen teaSelenium-enriched green teaPI3K/Akt pathwayMicrobial profile |
| spellingShingle | Meirong Wu Xiaobin Wu Jiangxiong Zhu Fanglan Li Xinlin Wei Yuanfeng Wang Selenium-enriched and ordinary green tea extracts prevent high blood pressure and alter gut microbiota composition of hypertensive rats caused by high-salt diet Food Science and Human Wellness High-salt diet Hypertension Green tea Selenium-enriched green tea PI3K/Akt pathway Microbial profile |
| title | Selenium-enriched and ordinary green tea extracts prevent high blood pressure and alter gut microbiota composition of hypertensive rats caused by high-salt diet |
| title_full | Selenium-enriched and ordinary green tea extracts prevent high blood pressure and alter gut microbiota composition of hypertensive rats caused by high-salt diet |
| title_fullStr | Selenium-enriched and ordinary green tea extracts prevent high blood pressure and alter gut microbiota composition of hypertensive rats caused by high-salt diet |
| title_full_unstemmed | Selenium-enriched and ordinary green tea extracts prevent high blood pressure and alter gut microbiota composition of hypertensive rats caused by high-salt diet |
| title_short | Selenium-enriched and ordinary green tea extracts prevent high blood pressure and alter gut microbiota composition of hypertensive rats caused by high-salt diet |
| title_sort | selenium enriched and ordinary green tea extracts prevent high blood pressure and alter gut microbiota composition of hypertensive rats caused by high salt diet |
| topic | High-salt diet Hypertension Green tea Selenium-enriched green tea PI3K/Akt pathway Microbial profile |
| url | http://www.sciencedirect.com/science/article/pii/S2213453021001592 |
| work_keys_str_mv | AT meirongwu seleniumenrichedandordinarygreenteaextractspreventhighbloodpressureandaltergutmicrobiotacompositionofhypertensiveratscausedbyhighsaltdiet AT xiaobinwu seleniumenrichedandordinarygreenteaextractspreventhighbloodpressureandaltergutmicrobiotacompositionofhypertensiveratscausedbyhighsaltdiet AT jiangxiongzhu seleniumenrichedandordinarygreenteaextractspreventhighbloodpressureandaltergutmicrobiotacompositionofhypertensiveratscausedbyhighsaltdiet AT fanglanli seleniumenrichedandordinarygreenteaextractspreventhighbloodpressureandaltergutmicrobiotacompositionofhypertensiveratscausedbyhighsaltdiet AT xinlinwei seleniumenrichedandordinarygreenteaextractspreventhighbloodpressureandaltergutmicrobiotacompositionofhypertensiveratscausedbyhighsaltdiet AT yuanfengwang seleniumenrichedandordinarygreenteaextractspreventhighbloodpressureandaltergutmicrobiotacompositionofhypertensiveratscausedbyhighsaltdiet |