The correlation between abnormal metabolic indexes and the severity of coronary artery lesions in patients with acute coronary syndrome
ObjectiveTo explore the influencing factors of coronary artery lesion severity in patients with acute coronary syndrome (ACS). MethodsClinical data of ACS patients admitted to Zhongshan Hospital, Fudan University from December 2017 to December 2019 were consecutively collected. The modified Gensini...
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Shanghai Chinese Clinical Medicine Press Co., Ltd.
2025-06-01
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| Series: | Zhongguo Linchuang Yixue |
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| Online Access: | https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2025.20250342 |
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| author | Yajun ZHAO Ming LIU Yuxiang DAI Xiaopan LI Xuelin CHENG Qizhe WANG Ru LIU Yaxin XU Sunfang JIANG |
| author_facet | Yajun ZHAO Ming LIU Yuxiang DAI Xiaopan LI Xuelin CHENG Qizhe WANG Ru LIU Yaxin XU Sunfang JIANG |
| author_sort | Yajun ZHAO |
| collection | DOAJ |
| description | ObjectiveTo explore the influencing factors of coronary artery lesion severity in patients with acute coronary syndrome (ACS). MethodsClinical data of ACS patients admitted to Zhongshan Hospital, Fudan University from December 2017 to December 2019 were consecutively collected. The modified Gensini score was used to assess the severity of coronary artery lesions. Univariate and multivariate linear regression analyses were performed to identify independent factors associated with coronary artery lesion severity. ResultsA total of 1 689 ACS patients were included, with an average age of (64.04±11.45) years; 1 353 (80.11%) were male, and the mean modified Gensini score was (8.12±4.03). Multivariate linear regression analysis revealed that sex (β＝0.97, P＝0.001), age (β＝0.03, P＝0.021), estimated glomerular filtration rate (eGFR; β＝－0.03, P＜0.001), low-density lipoprotein cholesterol (LDL-C; β＝0.58, P＜0.001), apolipoprotein A1 (Apo A1; β＝－1.28, P＝0.012), lipoprotein(a) [Lp(a); β＝0.001, P＝0.033], and glycated hemoglobin A1C (HbA1C; β＝0.45, P＜0.001) were independent influencing factors of the modified Gensini score. ConclusionsMetabolic indicators, including Apo A1, LDL-C, HbA1C, and Lp(a), may serve as risk factors for coronary artery lesion severity in ACS patients, with Apo A1 demonstrating the strongest impact. |
| format | Article |
| id | doaj-art-93963bfbdbf2473dacf6d24785465a3b |
| institution | Kabale University |
| issn | 1008-6358 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Shanghai Chinese Clinical Medicine Press Co., Ltd. |
| record_format | Article |
| series | Zhongguo Linchuang Yixue |
| spelling | doaj-art-93963bfbdbf2473dacf6d24785465a3b2025-08-20T03:50:07ZengShanghai Chinese Clinical Medicine Press Co., Ltd.Zhongguo Linchuang Yixue1008-63582025-06-0132344144810.12025/j.issn.1008-6358.2025.2025034220250342The correlation between abnormal metabolic indexes and the severity of coronary artery lesions in patients with acute coronary syndromeYajun ZHAO0Ming LIU1Yuxiang DAI2Xiaopan LI3Xuelin CHENG4Qizhe WANG5Ru LIU6Yaxin XU7Sunfang JIANG8Health Management Center, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaHealth Management Center, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaHealth Management Center, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of General Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaHealth Management Center, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaHealth Management Center, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of General Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaHealth Management Center, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaObjectiveTo explore the influencing factors of coronary artery lesion severity in patients with acute coronary syndrome (ACS). MethodsClinical data of ACS patients admitted to Zhongshan Hospital, Fudan University from December 2017 to December 2019 were consecutively collected. The modified Gensini score was used to assess the severity of coronary artery lesions. Univariate and multivariate linear regression analyses were performed to identify independent factors associated with coronary artery lesion severity. ResultsA total of 1 689 ACS patients were included, with an average age of (64.04±11.45) years; 1 353 (80.11%) were male, and the mean modified Gensini score was (8.12±4.03). Multivariate linear regression analysis revealed that sex (β＝0.97, P＝0.001), age (β＝0.03, P＝0.021), estimated glomerular filtration rate (eGFR; β＝－0.03, P＜0.001), low-density lipoprotein cholesterol (LDL-C; β＝0.58, P＜0.001), apolipoprotein A1 (Apo A1; β＝－1.28, P＝0.012), lipoprotein(a) [Lp(a); β＝0.001, P＝0.033], and glycated hemoglobin A1C (HbA1C; β＝0.45, P＜0.001) were independent influencing factors of the modified Gensini score. ConclusionsMetabolic indicators, including Apo A1, LDL-C, HbA1C, and Lp(a), may serve as risk factors for coronary artery lesion severity in ACS patients, with Apo A1 demonstrating the strongest impact.https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2025.20250342acute coronary syndromemetabolic indicatorcoronary artery lesionmodified gensini score |
| spellingShingle | Yajun ZHAO Ming LIU Yuxiang DAI Xiaopan LI Xuelin CHENG Qizhe WANG Ru LIU Yaxin XU Sunfang JIANG The correlation between abnormal metabolic indexes and the severity of coronary artery lesions in patients with acute coronary syndrome Zhongguo Linchuang Yixue acute coronary syndrome metabolic indicator coronary artery lesion modified gensini score |
| title | The correlation between abnormal metabolic indexes and the severity of coronary artery lesions in patients with acute coronary syndrome |
| title_full | The correlation between abnormal metabolic indexes and the severity of coronary artery lesions in patients with acute coronary syndrome |
| title_fullStr | The correlation between abnormal metabolic indexes and the severity of coronary artery lesions in patients with acute coronary syndrome |
| title_full_unstemmed | The correlation between abnormal metabolic indexes and the severity of coronary artery lesions in patients with acute coronary syndrome |
| title_short | The correlation between abnormal metabolic indexes and the severity of coronary artery lesions in patients with acute coronary syndrome |
| title_sort | correlation between abnormal metabolic indexes and the severity of coronary artery lesions in patients with acute coronary syndrome |
| topic | acute coronary syndrome metabolic indicator coronary artery lesion modified gensini score |
| url | https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2025.20250342 |
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