Network pharmacology integrated with molecular docking and experimental validation elucidates the therapeutic potential of Forsythiae Fructus extract against hepatitis B virus-related hepatocellular carcinoma

Network pharmacology integrated with molecular docking and experimental validation elucidates the therapeutic potential of Forsythiae Fructus extract against hepatitis B virus-related hepatocellular carcinoma

BackgroundForsythiae Fructus (FF), a widely used traditional Chinese medicine, possesses anti-inflammatory, antiviral, and anticancer properties. However, the precise anticancer mechanisms of FF against hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) remain poorly understood. This stu...

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Bibliographic Details
Main Authors: Fuqing Chen, Yifan Cai, Changzhou Chen, Jianyin Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Oncology
Subjects:
Forsythiae Fructus
network pharmacology
molecular docking
hepatitis B virus
hepatocellular carcinoma
bicuculline
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1571537/full
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