Tape Strip Profiling of Checkpoint Inhibitor–Associated Dermatitis Highlights Pan-T-Cell Activation: A Pilot Study
Immune checkpoint inhibitors (ICIs) have become mainstay therapy in the treatment of certain cancers. However, they are frequently associated with adverse effects in nontumor tissues. Cutaneous immune-related adverse events are the most prevalent toxicities, yet their underlying mechanisms remain po...
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Elsevier
2025-07-01
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| Series: | JID Innovations |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667026725000311 |
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| author | Camille M. Powers Madeline Kim Annie Chang Benjamin D. Hu Brandon R. Block Austin J. Piontkowski Jeremy Orloff Jade N. Young Yeriel D. Estrada Digpal S. Gour Emma Guttman-Yassky Nicholas Gulati |
| author_facet | Camille M. Powers Madeline Kim Annie Chang Benjamin D. Hu Brandon R. Block Austin J. Piontkowski Jeremy Orloff Jade N. Young Yeriel D. Estrada Digpal S. Gour Emma Guttman-Yassky Nicholas Gulati |
| author_sort | Camille M. Powers |
| collection | DOAJ |
| description | Immune checkpoint inhibitors (ICIs) have become mainstay therapy in the treatment of certain cancers. However, they are frequently associated with adverse effects in nontumor tissues. Cutaneous immune-related adverse events are the most prevalent toxicities, yet their underlying mechanisms remain poorly understood. This pilot study investigated the molecular phenotype of ICI-associated eczematous dermatitis and ICI–associated lichen planus using minimally invasive tape strip sampling to compare these conditions with patients with atopic dermatitis and healthy controls. Transcriptomic analysis revealed significant T helper 1 upregulation in lesional ICI-associated eczematous dermatitis and ICI–associated lichen planus, surpassing the dysregulation seen in atopic dermatitis. T helper 2–related markers, including IL4R, were elevated in both ICI subtypes, aligning with prior clinical reports of dupilumab efficacy for cutaneous immune-related adverse events. Notably, JAK3 modulation was uniquely observed in lesional ICI-associated eczematous dermatitis. Lesional and nonlesional ICI–associated lichen planus demonstrated broad immune dysregulation, suggesting possible early inflammatory activity in seemingly unaffected skin. These findings highlight distinct immune pathway alterations in cutaneous immune-related adverse events compared with their ICI-independent counterparts, shedding light on potential therapeutic targets to manage these conditions without compromising ICI efficacy. Future studies in larger cohorts are warranted to validate these observations and evaluate targeted interventions for cutaneous immune-related adverse events. |
| format | Article |
| id | doaj-art-9395917f756f4095b8a7902ffd9de7ec |
| institution | Kabale University |
| issn | 2667-0267 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JID Innovations |
| spelling | doaj-art-9395917f756f4095b8a7902ffd9de7ec2025-08-20T03:34:00ZengElsevierJID Innovations2667-02672025-07-015410037510.1016/j.xjidi.2025.100375Tape Strip Profiling of Checkpoint Inhibitor–Associated Dermatitis Highlights Pan-T-Cell Activation: A Pilot StudyCamille M. Powers0Madeline Kim1Annie Chang2Benjamin D. Hu3Brandon R. Block4Austin J. Piontkowski5Jeremy Orloff6Jade N. Young7Yeriel D. Estrada8Digpal S. Gour9Emma Guttman-Yassky10Nicholas Gulati11Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USADepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USADepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USADepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USADepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USADepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USADepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USADepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USADepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USADepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USADepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USADepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Correspondence: Nicholas Gulati, Department of Dermatology, Icahn School of Medicine at Mount Sinai, 5 East 98th Street, 5th Floor, New York, New York 10029, USA.Immune checkpoint inhibitors (ICIs) have become mainstay therapy in the treatment of certain cancers. However, they are frequently associated with adverse effects in nontumor tissues. Cutaneous immune-related adverse events are the most prevalent toxicities, yet their underlying mechanisms remain poorly understood. This pilot study investigated the molecular phenotype of ICI-associated eczematous dermatitis and ICI–associated lichen planus using minimally invasive tape strip sampling to compare these conditions with patients with atopic dermatitis and healthy controls. Transcriptomic analysis revealed significant T helper 1 upregulation in lesional ICI-associated eczematous dermatitis and ICI–associated lichen planus, surpassing the dysregulation seen in atopic dermatitis. T helper 2–related markers, including IL4R, were elevated in both ICI subtypes, aligning with prior clinical reports of dupilumab efficacy for cutaneous immune-related adverse events. Notably, JAK3 modulation was uniquely observed in lesional ICI-associated eczematous dermatitis. Lesional and nonlesional ICI–associated lichen planus demonstrated broad immune dysregulation, suggesting possible early inflammatory activity in seemingly unaffected skin. These findings highlight distinct immune pathway alterations in cutaneous immune-related adverse events compared with their ICI-independent counterparts, shedding light on potential therapeutic targets to manage these conditions without compromising ICI efficacy. Future studies in larger cohorts are warranted to validate these observations and evaluate targeted interventions for cutaneous immune-related adverse events.http://www.sciencedirect.com/science/article/pii/S2667026725000311Atopic dermatitisCutaneous immune-related adverse eventsOncodermatologyRNA sequencingTape strips |
| spellingShingle | Camille M. Powers Madeline Kim Annie Chang Benjamin D. Hu Brandon R. Block Austin J. Piontkowski Jeremy Orloff Jade N. Young Yeriel D. Estrada Digpal S. Gour Emma Guttman-Yassky Nicholas Gulati Tape Strip Profiling of Checkpoint Inhibitor–Associated Dermatitis Highlights Pan-T-Cell Activation: A Pilot Study JID Innovations Atopic dermatitis Cutaneous immune-related adverse events Oncodermatology RNA sequencing Tape strips |
| title | Tape Strip Profiling of Checkpoint Inhibitor–Associated Dermatitis Highlights Pan-T-Cell Activation: A Pilot Study |
| title_full | Tape Strip Profiling of Checkpoint Inhibitor–Associated Dermatitis Highlights Pan-T-Cell Activation: A Pilot Study |
| title_fullStr | Tape Strip Profiling of Checkpoint Inhibitor–Associated Dermatitis Highlights Pan-T-Cell Activation: A Pilot Study |
| title_full_unstemmed | Tape Strip Profiling of Checkpoint Inhibitor–Associated Dermatitis Highlights Pan-T-Cell Activation: A Pilot Study |
| title_short | Tape Strip Profiling of Checkpoint Inhibitor–Associated Dermatitis Highlights Pan-T-Cell Activation: A Pilot Study |
| title_sort | tape strip profiling of checkpoint inhibitor associated dermatitis highlights pan t cell activation a pilot study |
| topic | Atopic dermatitis Cutaneous immune-related adverse events Oncodermatology RNA sequencing Tape strips |
| url | http://www.sciencedirect.com/science/article/pii/S2667026725000311 |
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