Inspiratory muscle training and aerobic exercise for respiratory muscle strength in myasthenia gravis post-hospitalization- a randomized controlled trial
Abstract Background Previous studies have demonstrated the positive effects of long-term inspiratory muscle training (IMT) on inspiratory muscle strength and pulmonary function. However, the benefits of IMT with aerobic exercise (IMT + AE) in patients with myasthenia gravis (MG) remain unclear. This...
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BMC
2025-05-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-025-03733-7 |
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| author | Chia-Ling Chang Tien-Pei Fang Hsin-Mao Tsai Hui-Chin Chen Shih-Feng Liu Hui-Ling Lin Jui-Fang Liu |
| author_facet | Chia-Ling Chang Tien-Pei Fang Hsin-Mao Tsai Hui-Chin Chen Shih-Feng Liu Hui-Ling Lin Jui-Fang Liu |
| author_sort | Chia-Ling Chang |
| collection | DOAJ |
| description | Abstract Background Previous studies have demonstrated the positive effects of long-term inspiratory muscle training (IMT) on inspiratory muscle strength and pulmonary function. However, the benefits of IMT with aerobic exercise (IMT + AE) in patients with myasthenia gravis (MG) remain unclear. This randomized controlled trial aimed to assess the impact of the early, 6-week, moderate-intensity interval IMT + AE on pulmonary function, functional capacity, and respiratory muscle strength in patients with MG post-hospitalization. Methods Patients with Discharged MG were randomly assigned to either a control group receiving standard medical management or an intervention group undergoing six-week IMT + AE program. Respiratory status was evaluated using the maximum inspiratory/expiratory pressure (MIP/MEP) and pulmonary function tests. Modified Borg dyspnea scores and a six-minute walk test for functional capacity were also employed. Results Fifty-four participants were assigned to either the control (sixn = 28) or IMT + AE groups (n = 26). At 6 weeks, the IMT + AE group showed significant improvements across all parameters, while the control group only showed notable differences in the modified Borg scale scores and walking distance. MIP improvements were 33.8 ± 36.1 cmH2O in IMT and 22.1 ± 25.8 cmH2O in control groups (P = 0.18). The IMT + AE group improvements were more substantial in MEP, modified Borg scale, and 6-minute walk distance, in addition to forced vital capacity (FVC) and FVC % of prediction (0.21 ± 0.24 L and 6.17 ± 6.01%, respectively), while the control group showed decreased volumes (-0.06 ± 0.30 L and − 1.79 ± 9.69%, respectively). FVC improvement was significant with IMT + AE (0.21 ± 0.24 L) vs. reduction in the control group (-0.06 ± 0.3 L; P = 0.001). Conclusions Implementing six-week moderate-intensity interval IMT + AE effectively enhanced respiratory muscle strength, alleviated dyspnea, improved physical capacity, and increased FVC in patients with MG following hospitalization after discharge. Clinical trial registration The study was registered in The Clinical Trials Clinical Trial (NCT06624345|| https://www.clinicaltrials.gov/ ) on October 12, 2024 (retrospectively registered). |
| format | Article |
| id | doaj-art-939193a9e60d4e1986ba3a3d6def8c8a |
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| publishDate | 2025-05-01 |
| publisher | BMC |
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| series | BMC Pulmonary Medicine |
| spelling | doaj-art-939193a9e60d4e1986ba3a3d6def8c8a2025-08-20T02:39:04ZengBMCBMC Pulmonary Medicine1471-24662025-05-0125111010.1186/s12890-025-03733-7Inspiratory muscle training and aerobic exercise for respiratory muscle strength in myasthenia gravis post-hospitalization- a randomized controlled trialChia-Ling Chang0Tien-Pei Fang1Hsin-Mao Tsai2Hui-Chin Chen3Shih-Feng Liu4Hui-Ling Lin5Jui-Fang Liu6Department of Respiratory Therapy, Kaohsiung Municipal Fong Shan Hospital - Under the management of Chang Gung Medical FoundationDepartment of Respiratory Care, Chang Gung University of Science and TechnologyDepartment of Pharmacy, Chia Nan University of Pharmacy & ScienceDepartment of Respiratory Care, Chang Gung University of Science and TechnologyDepartment of Respiratory Therapy, Kaohsiung Municipal Fong Shan Hospital - Under the management of Chang Gung Medical FoundationDepartment of Respiratory Care, Chang Gung University of Science and TechnologyDepartment of Respiratory Care, Chang Gung University of Science and TechnologyAbstract Background Previous studies have demonstrated the positive effects of long-term inspiratory muscle training (IMT) on inspiratory muscle strength and pulmonary function. However, the benefits of IMT with aerobic exercise (IMT + AE) in patients with myasthenia gravis (MG) remain unclear. This randomized controlled trial aimed to assess the impact of the early, 6-week, moderate-intensity interval IMT + AE on pulmonary function, functional capacity, and respiratory muscle strength in patients with MG post-hospitalization. Methods Patients with Discharged MG were randomly assigned to either a control group receiving standard medical management or an intervention group undergoing six-week IMT + AE program. Respiratory status was evaluated using the maximum inspiratory/expiratory pressure (MIP/MEP) and pulmonary function tests. Modified Borg dyspnea scores and a six-minute walk test for functional capacity were also employed. Results Fifty-four participants were assigned to either the control (sixn = 28) or IMT + AE groups (n = 26). At 6 weeks, the IMT + AE group showed significant improvements across all parameters, while the control group only showed notable differences in the modified Borg scale scores and walking distance. MIP improvements were 33.8 ± 36.1 cmH2O in IMT and 22.1 ± 25.8 cmH2O in control groups (P = 0.18). The IMT + AE group improvements were more substantial in MEP, modified Borg scale, and 6-minute walk distance, in addition to forced vital capacity (FVC) and FVC % of prediction (0.21 ± 0.24 L and 6.17 ± 6.01%, respectively), while the control group showed decreased volumes (-0.06 ± 0.30 L and − 1.79 ± 9.69%, respectively). FVC improvement was significant with IMT + AE (0.21 ± 0.24 L) vs. reduction in the control group (-0.06 ± 0.3 L; P = 0.001). Conclusions Implementing six-week moderate-intensity interval IMT + AE effectively enhanced respiratory muscle strength, alleviated dyspnea, improved physical capacity, and increased FVC in patients with MG following hospitalization after discharge. Clinical trial registration The study was registered in The Clinical Trials Clinical Trial (NCT06624345|| https://www.clinicaltrials.gov/ ) on October 12, 2024 (retrospectively registered).https://doi.org/10.1186/s12890-025-03733-7Myasthenia gravisBreathing exercisesMuscle strengthPulmonary function testsMaximal respiratory pressures6-minute walk test |
| spellingShingle | Chia-Ling Chang Tien-Pei Fang Hsin-Mao Tsai Hui-Chin Chen Shih-Feng Liu Hui-Ling Lin Jui-Fang Liu Inspiratory muscle training and aerobic exercise for respiratory muscle strength in myasthenia gravis post-hospitalization- a randomized controlled trial BMC Pulmonary Medicine Myasthenia gravis Breathing exercises Muscle strength Pulmonary function tests Maximal respiratory pressures 6-minute walk test |
| title | Inspiratory muscle training and aerobic exercise for respiratory muscle strength in myasthenia gravis post-hospitalization- a randomized controlled trial |
| title_full | Inspiratory muscle training and aerobic exercise for respiratory muscle strength in myasthenia gravis post-hospitalization- a randomized controlled trial |
| title_fullStr | Inspiratory muscle training and aerobic exercise for respiratory muscle strength in myasthenia gravis post-hospitalization- a randomized controlled trial |
| title_full_unstemmed | Inspiratory muscle training and aerobic exercise for respiratory muscle strength in myasthenia gravis post-hospitalization- a randomized controlled trial |
| title_short | Inspiratory muscle training and aerobic exercise for respiratory muscle strength in myasthenia gravis post-hospitalization- a randomized controlled trial |
| title_sort | inspiratory muscle training and aerobic exercise for respiratory muscle strength in myasthenia gravis post hospitalization a randomized controlled trial |
| topic | Myasthenia gravis Breathing exercises Muscle strength Pulmonary function tests Maximal respiratory pressures 6-minute walk test |
| url | https://doi.org/10.1186/s12890-025-03733-7 |
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