Treatment of basal cell carcinoma of the nose with a combination of Interferon alpha-2b and gamma
Introduction: Basal cell carcinoma is a malignant neoplasm derived from epidermal cells of hair follicles or non-keratinized cells with a high potential for local destruction, which can be disfiguring and may invade the surrounding tissue, resulting in deformities or loss of function of the affected...
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Universidad de Ciencias Médicas de La Habana
2022-12-01
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| Series: | Revista Habanera de Ciencias Médicas |
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| Online Access: | https://revhabanera.sld.cu/index.php/rhab/article/view/4723 |
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| author | Vladimir Sánchez Linares Belkys Martinez Fando Tatiana Hernández González Aneysis González Pérez Iraldo Bello Rivero |
| author_facet | Vladimir Sánchez Linares Belkys Martinez Fando Tatiana Hernández González Aneysis González Pérez Iraldo Bello Rivero |
| author_sort | Vladimir Sánchez Linares |
| collection | DOAJ |
| description | Introduction: Basal cell carcinoma is a malignant neoplasm derived from epidermal cells of hair follicles or non-keratinized cells with a high potential for local destruction, which can be disfiguring and may invade the surrounding tissue, resulting in deformities or loss of function of the affected organ, being more frequent in protruding areas such as the nose.
Objective: To describe the results of the application of the synergistic combination of interferon alpha-2b and gamma in a series of cases with nasal basal cell carcinoma.
Material and Methods: An observational, descriptive and longitudinal study was carried out in a series of 28 clinical cases with basal cell carcinoma of the nose who attended the dermatology clinic of Policlínico Centro in Sancti Spiritus in the period from january 2016 to december 2021. Cases with a clinical, dermoscopic and histopathological diagnoses were included. An initial and a final evaluation at the end of the 16 weeks of treatment were carried out; also, 10,5 IU of HeberFERON was administered 3 times per week perilesional and intradermally until completing 9 doses. The main variables were response to treatment and presence or absence of adverse events.
Results: Male sex, skin phototype II, location on the dorsum and nasal ala, clinical subtype ulcerative nodule, and solid histological subtype predominated. In most of the patients, the tumor disappeared at the end of the therapeutic regime. The most common adverse events were pain at the injection site, fever, edema and perilesional erythema.
Conclusions: There was a complete response to treatment in most patients and the adverse events were those described in the literature with no change in the pharmacological attitude. |
| format | Article |
| id | doaj-art-93913a9ed7a9464183df2f1246e07e57 |
| institution | OA Journals |
| issn | 1729-519X |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Universidad de Ciencias Médicas de La Habana |
| record_format | Article |
| series | Revista Habanera de Ciencias Médicas |
| spelling | doaj-art-93913a9ed7a9464183df2f1246e07e572025-08-20T02:32:10ZengUniversidad de Ciencias Médicas de La HabanaRevista Habanera de Ciencias Médicas1729-519X2022-12-01215e4723e47231977Treatment of basal cell carcinoma of the nose with a combination of Interferon alpha-2b and gammaVladimir Sánchez Linares0Belkys Martinez Fando1Tatiana Hernández González2Aneysis González Pérez3Iraldo Bello Rivero4Universidad de Ciencias Médicas de Sancti Spíritus. Policlínico Docente Área Centro. Sancti Spíritus.Universidad de Ciencias Médicas de Sancti Spíritus. Policlínico Universitario “Camilo Cienfuegos”. Sancti Spíritus.Universidad de Ciencias Médicas de Sancti Spíritus. Hospital General Provincial “Camilo Cienfuegos”. Sancti SpíritusUniversidad de Ciencias Médicas de Sancti Spíritus. Policlínico Docente Área Centro. Sancti Spíritus.Centro de Ingeniería Genética y Biotecnología, La Habana.Introduction: Basal cell carcinoma is a malignant neoplasm derived from epidermal cells of hair follicles or non-keratinized cells with a high potential for local destruction, which can be disfiguring and may invade the surrounding tissue, resulting in deformities or loss of function of the affected organ, being more frequent in protruding areas such as the nose. Objective: To describe the results of the application of the synergistic combination of interferon alpha-2b and gamma in a series of cases with nasal basal cell carcinoma. Material and Methods: An observational, descriptive and longitudinal study was carried out in a series of 28 clinical cases with basal cell carcinoma of the nose who attended the dermatology clinic of Policlínico Centro in Sancti Spiritus in the period from january 2016 to december 2021. Cases with a clinical, dermoscopic and histopathological diagnoses were included. An initial and a final evaluation at the end of the 16 weeks of treatment were carried out; also, 10,5 IU of HeberFERON was administered 3 times per week perilesional and intradermally until completing 9 doses. The main variables were response to treatment and presence or absence of adverse events. Results: Male sex, skin phototype II, location on the dorsum and nasal ala, clinical subtype ulcerative nodule, and solid histological subtype predominated. In most of the patients, the tumor disappeared at the end of the therapeutic regime. The most common adverse events were pain at the injection site, fever, edema and perilesional erythema. Conclusions: There was a complete response to treatment in most patients and the adverse events were those described in the literature with no change in the pharmacological attitude.https://revhabanera.sld.cu/index.php/rhab/article/view/4723palabras claves: interferones, carcinoma basocelular, nariz, cáncer de piel no melanoma, heberferon. |
| spellingShingle | Vladimir Sánchez Linares Belkys Martinez Fando Tatiana Hernández González Aneysis González Pérez Iraldo Bello Rivero Treatment of basal cell carcinoma of the nose with a combination of Interferon alpha-2b and gamma Revista Habanera de Ciencias Médicas palabras claves: interferones, carcinoma basocelular, nariz, cáncer de piel no melanoma, heberferon. |
| title | Treatment of basal cell carcinoma of the nose with a combination of Interferon alpha-2b and gamma |
| title_full | Treatment of basal cell carcinoma of the nose with a combination of Interferon alpha-2b and gamma |
| title_fullStr | Treatment of basal cell carcinoma of the nose with a combination of Interferon alpha-2b and gamma |
| title_full_unstemmed | Treatment of basal cell carcinoma of the nose with a combination of Interferon alpha-2b and gamma |
| title_short | Treatment of basal cell carcinoma of the nose with a combination of Interferon alpha-2b and gamma |
| title_sort | treatment of basal cell carcinoma of the nose with a combination of interferon alpha 2b and gamma |
| topic | palabras claves: interferones, carcinoma basocelular, nariz, cáncer de piel no melanoma, heberferon. |
| url | https://revhabanera.sld.cu/index.php/rhab/article/view/4723 |
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