Bilateral Metachronous Typical and Atypical Carcinoid Tumors of the Lung
ABSTRACT Bronchial carcinoids are uncommon neuroendocrine tumors. According to their pathological differentiation, they are divided into typical and atypical forms, with diverse biological behavior and aggressiveness. Bronchial carcinoids may be associated with familial neuroendocrine syndromes, suc...
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| Format: | Article |
| Language: | English |
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Wiley
2025-04-01
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| Series: | Thoracic Cancer |
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| Online Access: | https://doi.org/10.1111/1759-7714.70078 |
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| author | Alberto Busetto Giovanni Maria Comacchio Vincenzo Verzeletti Fares Shamshoum Francesco Fortarezza Federica Pezzuto Andrea Dell'Amore Fiorella Calabrese Federico Rea |
| author_facet | Alberto Busetto Giovanni Maria Comacchio Vincenzo Verzeletti Fares Shamshoum Francesco Fortarezza Federica Pezzuto Andrea Dell'Amore Fiorella Calabrese Federico Rea |
| author_sort | Alberto Busetto |
| collection | DOAJ |
| description | ABSTRACT Bronchial carcinoids are uncommon neuroendocrine tumors. According to their pathological differentiation, they are divided into typical and atypical forms, with diverse biological behavior and aggressiveness. Bronchial carcinoids may be associated with familial neuroendocrine syndromes, such as MEN‐1. They can also present initially as diffuse hyperplastic proliferation of neuroendocrine foci throughout the pulmonary parenchyma (DIPNECH). Metachronous and bilateral forms are sporadic in the literature. We describe a case of a 68‐year‐old man with metachronous bilateral typical‐atypical carcinoid neoplasms. The patient was treated with a two‐stage mini‐invasive pulmonary surgery in a time frame of 5 years. This case may be unique because it features two rare and distinct pathological entities in the same patient, not associated with any known genetic mutation. Carcinoid tumors require multidisciplinary care and a collaborative approach due to their pleomorphic behavior, ensuring comprehensive management and maximizing therapeutic efficacy. |
| format | Article |
| id | doaj-art-938dd7a8ac0e428ea476292b58f74cdc |
| institution | OA Journals |
| issn | 1759-7706 1759-7714 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj-art-938dd7a8ac0e428ea476292b58f74cdc2025-08-20T02:19:04ZengWileyThoracic Cancer1759-77061759-77142025-04-01168n/an/a10.1111/1759-7714.70078Bilateral Metachronous Typical and Atypical Carcinoid Tumors of the LungAlberto Busetto0Giovanni Maria Comacchio1Vincenzo Verzeletti2Fares Shamshoum3Francesco Fortarezza4Federica Pezzuto5Andrea Dell'Amore6Fiorella Calabrese7Federico Rea8Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua Padua ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua Padua ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua Padua ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua Padua ItalyPathology Unit, Division of Integrated Diagnostics University ‐ Hospital of Padua Padua ItalyPathology Unit, Division of Integrated Diagnostics University ‐ Hospital of Padua Padua ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua Padua ItalyPathology Unit, Division of Integrated Diagnostics University ‐ Hospital of Padua Padua ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua Padua ItalyABSTRACT Bronchial carcinoids are uncommon neuroendocrine tumors. According to their pathological differentiation, they are divided into typical and atypical forms, with diverse biological behavior and aggressiveness. Bronchial carcinoids may be associated with familial neuroendocrine syndromes, such as MEN‐1. They can also present initially as diffuse hyperplastic proliferation of neuroendocrine foci throughout the pulmonary parenchyma (DIPNECH). Metachronous and bilateral forms are sporadic in the literature. We describe a case of a 68‐year‐old man with metachronous bilateral typical‐atypical carcinoid neoplasms. The patient was treated with a two‐stage mini‐invasive pulmonary surgery in a time frame of 5 years. This case may be unique because it features two rare and distinct pathological entities in the same patient, not associated with any known genetic mutation. Carcinoid tumors require multidisciplinary care and a collaborative approach due to their pleomorphic behavior, ensuring comprehensive management and maximizing therapeutic efficacy.https://doi.org/10.1111/1759-7714.70078atypical carcinoidbilateral pulmonary tumorsmetachronous tumorsmini‐invasive surgerytypical carcinoid |
| spellingShingle | Alberto Busetto Giovanni Maria Comacchio Vincenzo Verzeletti Fares Shamshoum Francesco Fortarezza Federica Pezzuto Andrea Dell'Amore Fiorella Calabrese Federico Rea Bilateral Metachronous Typical and Atypical Carcinoid Tumors of the Lung Thoracic Cancer atypical carcinoid bilateral pulmonary tumors metachronous tumors mini‐invasive surgery typical carcinoid |
| title | Bilateral Metachronous Typical and Atypical Carcinoid Tumors of the Lung |
| title_full | Bilateral Metachronous Typical and Atypical Carcinoid Tumors of the Lung |
| title_fullStr | Bilateral Metachronous Typical and Atypical Carcinoid Tumors of the Lung |
| title_full_unstemmed | Bilateral Metachronous Typical and Atypical Carcinoid Tumors of the Lung |
| title_short | Bilateral Metachronous Typical and Atypical Carcinoid Tumors of the Lung |
| title_sort | bilateral metachronous typical and atypical carcinoid tumors of the lung |
| topic | atypical carcinoid bilateral pulmonary tumors metachronous tumors mini‐invasive surgery typical carcinoid |
| url | https://doi.org/10.1111/1759-7714.70078 |
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