Longitudinal Assessment of Area of Reticular Pseudodrusen in Eyes with Age-Related Macular Degeneration
Purpose: To evaluate the change in the area of reticular pseudodrusen (RPD) and choroidal thickness over 2 years in eyes with age-related macular degeneration (AMD). Design: Longitudinal cohort study. Subjects: The study reviewed 1332 eyes from 666 subjects with baseline and 2-year follow-up data, o...
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Elsevier
2025-11-01
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| Series: | Ophthalmology Science |
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| author | Swetha Bindu Velaga, MS Ahmed Roshdy Alagorie, MD Muneeswar Gupta Nittala, MPhil Noel C. Moore, PhD Yeunjoo E. Song, PhD Jonathan Haines, PhD Margaret A. Pericak-Vance, PhD Dwight Stambolian, MD Zhihong Hu, PhD Ye He, MD, PhD Srinivas R. Sadda, MD |
| author_facet | Swetha Bindu Velaga, MS Ahmed Roshdy Alagorie, MD Muneeswar Gupta Nittala, MPhil Noel C. Moore, PhD Yeunjoo E. Song, PhD Jonathan Haines, PhD Margaret A. Pericak-Vance, PhD Dwight Stambolian, MD Zhihong Hu, PhD Ye He, MD, PhD Srinivas R. Sadda, MD |
| author_sort | Swetha Bindu Velaga, MS |
| collection | DOAJ |
| description | Purpose: To evaluate the change in the area of reticular pseudodrusen (RPD) and choroidal thickness over 2 years in eyes with age-related macular degeneration (AMD). Design: Longitudinal cohort study. Subjects: The study reviewed 1332 eyes from 666 subjects with baseline and 2-year follow-up data, of which 108 eyes were graded to have RPD. Among these, 35 eyes from 22 participants (mean age: 72.8 ± 8.9 years; range: 50–84; 37% female) were eligible for this analysis because they had early or intermediate AMD with RPD at baseline, absence of geographic atrophy at 2 years, and images that were gradable for the presence of RPD. Methods: Infrared reflectance (IR), blue-light fundus autofluorescence, and spectral-domain OCT were obtained for all subjects at baseline and at 2 years. Using the instrument software, a certified grader delineated the RPD area (mm2) on the IR image using the free hand tool. Choroidal thickness was measured for both baseline and month 24 using a previously described deep learning algorithm to compute a choroidal volume. Main Outcome Measures: Changes in RPD area (mm2) and mean volumetric choroidal thickness (μm) between baseline and 2 years. Results: The RPD area increased significantly (P < 0.001) by month 24 compared with baseline with a mean increase of 6.23 ± 4.64 mm2. The mean volumetric choroidal thickness was not significantly different from baseline 182.2 ± 94.36 (134.20–227.90) to month 24 178.2 ± 41.10 (109–258). Conclusions: In this longitudinal natural history analysis, we observed an increase in RPD area of >6 mm2 over 2 years in the absence of a significant change in choroidal thickness. Although AMD eyes with presence of RPD typically have a thinner choroid, the increase in extent of these lesions does not appear to be associated with further thinning of the choroid. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. |
| format | Article |
| id | doaj-art-938dce4299b24a1291086517b4d2fb01 |
| institution | DOAJ |
| issn | 2666-9145 |
| language | English |
| publishDate | 2025-11-01 |
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| spelling | doaj-art-938dce4299b24a1291086517b4d2fb012025-08-20T03:05:52ZengElsevierOphthalmology Science2666-91452025-11-015610088110.1016/j.xops.2025.100881Longitudinal Assessment of Area of Reticular Pseudodrusen in Eyes with Age-Related Macular DegenerationSwetha Bindu Velaga, MS0Ahmed Roshdy Alagorie, MD1Muneeswar Gupta Nittala, MPhil2Noel C. Moore, PhD3Yeunjoo E. Song, PhD4Jonathan Haines, PhD5Margaret A. Pericak-Vance, PhD6Dwight Stambolian, MD7Zhihong Hu, PhD8Ye He, MD, PhD9Srinivas R. Sadda, MD10Doheny Eye Institute, University of California-Los Angeles, Los Angeles, California; Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CaliforniaDepartment of Ophthalmology, Faculty of Medicine, Tanta University, Tanta, EgyptDoheny Eye Institute, University of California-Los Angeles, Los Angeles, California; Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CaliforniaDepartment of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio; Institute for Computational Biology, Case Western Reserve University, Cleveland, OhioDepartment of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio; Institute for Computational Biology, Case Western Reserve University, Cleveland, OhioDepartment of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio; Institute for Computational Biology, Case Western Reserve University, Cleveland, OhioJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FloridaDepartment of Ophthalmology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PennsylvaniaDoheny Eye Institute, University of California-Los Angeles, Los Angeles, California; Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CaliforniaDoheny Eye Institute, University of California-Los Angeles, Los Angeles, California; Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CaliforniaDoheny Eye Institute, University of California-Los Angeles, Los Angeles, California; Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California; Correspondence: Srinivas R. Sadda, MD, Doheny Eye Institute,150 North Orange Grove Boulevard, Pasadena, CA-91103, United States.Purpose: To evaluate the change in the area of reticular pseudodrusen (RPD) and choroidal thickness over 2 years in eyes with age-related macular degeneration (AMD). Design: Longitudinal cohort study. Subjects: The study reviewed 1332 eyes from 666 subjects with baseline and 2-year follow-up data, of which 108 eyes were graded to have RPD. Among these, 35 eyes from 22 participants (mean age: 72.8 ± 8.9 years; range: 50–84; 37% female) were eligible for this analysis because they had early or intermediate AMD with RPD at baseline, absence of geographic atrophy at 2 years, and images that were gradable for the presence of RPD. Methods: Infrared reflectance (IR), blue-light fundus autofluorescence, and spectral-domain OCT were obtained for all subjects at baseline and at 2 years. Using the instrument software, a certified grader delineated the RPD area (mm2) on the IR image using the free hand tool. Choroidal thickness was measured for both baseline and month 24 using a previously described deep learning algorithm to compute a choroidal volume. Main Outcome Measures: Changes in RPD area (mm2) and mean volumetric choroidal thickness (μm) between baseline and 2 years. Results: The RPD area increased significantly (P < 0.001) by month 24 compared with baseline with a mean increase of 6.23 ± 4.64 mm2. The mean volumetric choroidal thickness was not significantly different from baseline 182.2 ± 94.36 (134.20–227.90) to month 24 178.2 ± 41.10 (109–258). Conclusions: In this longitudinal natural history analysis, we observed an increase in RPD area of >6 mm2 over 2 years in the absence of a significant change in choroidal thickness. Although AMD eyes with presence of RPD typically have a thinner choroid, the increase in extent of these lesions does not appear to be associated with further thinning of the choroid. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.http://www.sciencedirect.com/science/article/pii/S2666914525001794Reticular pseudodrusenAge-related macular degeneration |
| spellingShingle | Swetha Bindu Velaga, MS Ahmed Roshdy Alagorie, MD Muneeswar Gupta Nittala, MPhil Noel C. Moore, PhD Yeunjoo E. Song, PhD Jonathan Haines, PhD Margaret A. Pericak-Vance, PhD Dwight Stambolian, MD Zhihong Hu, PhD Ye He, MD, PhD Srinivas R. Sadda, MD Longitudinal Assessment of Area of Reticular Pseudodrusen in Eyes with Age-Related Macular Degeneration Ophthalmology Science Reticular pseudodrusen Age-related macular degeneration |
| title | Longitudinal Assessment of Area of Reticular Pseudodrusen in Eyes with Age-Related Macular Degeneration |
| title_full | Longitudinal Assessment of Area of Reticular Pseudodrusen in Eyes with Age-Related Macular Degeneration |
| title_fullStr | Longitudinal Assessment of Area of Reticular Pseudodrusen in Eyes with Age-Related Macular Degeneration |
| title_full_unstemmed | Longitudinal Assessment of Area of Reticular Pseudodrusen in Eyes with Age-Related Macular Degeneration |
| title_short | Longitudinal Assessment of Area of Reticular Pseudodrusen in Eyes with Age-Related Macular Degeneration |
| title_sort | longitudinal assessment of area of reticular pseudodrusen in eyes with age related macular degeneration |
| topic | Reticular pseudodrusen Age-related macular degeneration |
| url | http://www.sciencedirect.com/science/article/pii/S2666914525001794 |
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