Trafficked Proteins—Druggable in Plasmodium falciparum?
Malaria is an infectious disease that results in serious health problems in the countries in which it is endemic. Annually this parasitic disease leads to more than half a million deaths; most of these are children in Africa. An effective vaccine is not available, and the treatment of the disease is...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2013/435981 |
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| author | Jasmin Lindner Kamila Anna Meissner Isolmar Schettert Carsten Wrenger |
| author_facet | Jasmin Lindner Kamila Anna Meissner Isolmar Schettert Carsten Wrenger |
| author_sort | Jasmin Lindner |
| collection | DOAJ |
| description | Malaria is an infectious disease that results in serious health problems in the countries in which it is endemic. Annually this parasitic disease leads to more than half a million deaths; most of these are children in Africa. An effective vaccine is not available, and the treatment of the disease is solely dependent on chemotherapy. However, drug resistance is spreading, and the identification of new drug targets as well as the development of new antimalarials is urgently required. Attention has been drawn to a variety of essential plasmodial proteins, which are targeted to intra- or extracellular destinations, such as the digestive vacuole, the apicoplast, or into the host cell. Interfering with the action or the transport of these proteins will impede proliferation of the parasite. In this mini review, we will shed light on the present discovery of chemotherapeutics and potential drug targets involved in protein trafficking processes in the malaria parasite. |
| format | Article |
| id | doaj-art-93893b845d8841dfbe8fd339cc49c872 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-93893b845d8841dfbe8fd339cc49c8722025-02-03T06:06:15ZengWileyInternational Journal of Cell Biology1687-88761687-88842013-01-01201310.1155/2013/435981435981Trafficked Proteins—Druggable in Plasmodium falciparum?Jasmin Lindner0Kamila Anna Meissner1Isolmar Schettert2Carsten Wrenger3Unit for Drug Discovery, Department of Parasitology, Institute of Biomedical Science, University of São Paulo, Avenida Prof. Lineu Prestes 1374, 05508-000 São Paulo, SP, BrazilUnit for Drug Discovery, Department of Parasitology, Institute of Biomedical Science, University of São Paulo, Avenida Prof. Lineu Prestes 1374, 05508-000 São Paulo, SP, BrazilLaboratory of Genetics and Molecular Cardiology, Heart Institute InCor, Avenida Dr. Eneas de Carvalho Aguiar 44, 05403-000 São Paulo, SP, BrazilUnit for Drug Discovery, Department of Parasitology, Institute of Biomedical Science, University of São Paulo, Avenida Prof. Lineu Prestes 1374, 05508-000 São Paulo, SP, BrazilMalaria is an infectious disease that results in serious health problems in the countries in which it is endemic. Annually this parasitic disease leads to more than half a million deaths; most of these are children in Africa. An effective vaccine is not available, and the treatment of the disease is solely dependent on chemotherapy. However, drug resistance is spreading, and the identification of new drug targets as well as the development of new antimalarials is urgently required. Attention has been drawn to a variety of essential plasmodial proteins, which are targeted to intra- or extracellular destinations, such as the digestive vacuole, the apicoplast, or into the host cell. Interfering with the action or the transport of these proteins will impede proliferation of the parasite. In this mini review, we will shed light on the present discovery of chemotherapeutics and potential drug targets involved in protein trafficking processes in the malaria parasite.http://dx.doi.org/10.1155/2013/435981 |
| spellingShingle | Jasmin Lindner Kamila Anna Meissner Isolmar Schettert Carsten Wrenger Trafficked Proteins—Druggable in Plasmodium falciparum? International Journal of Cell Biology |
| title | Trafficked Proteins—Druggable in Plasmodium falciparum? |
| title_full | Trafficked Proteins—Druggable in Plasmodium falciparum? |
| title_fullStr | Trafficked Proteins—Druggable in Plasmodium falciparum? |
| title_full_unstemmed | Trafficked Proteins—Druggable in Plasmodium falciparum? |
| title_short | Trafficked Proteins—Druggable in Plasmodium falciparum? |
| title_sort | trafficked proteins druggable in plasmodium falciparum |
| url | http://dx.doi.org/10.1155/2013/435981 |
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