Mechanistic insights into Rho/MRTF inhibition-induced apoptotic events and prevention of drug resistance in melanoma: implications for the involvement of pirin

Mechanistic insights into Rho/MRTF inhibition-induced apoptotic events and prevention of drug resistance in melanoma: implications for the involvement of pirin

AimOvercoming therapy resistance is critical for effective melanoma control. Upregulation of Rho/MRTF signaling in human and mouse melanomas causes resistance to targeted therapies. Inhibition of this pathway by MRTFi, CCG-257081 resensitized resistant melanomas to BRAF and MEK inhibitors. It also p...

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Bibliographic Details
Main Authors: Bardees M. Foda, Annika E. Baker, Łukasz Joachimiak, Marzena Mazur, Richard R. Neubig
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
melanoma
drug resistance
apoptosis
Rho/MRTF
pirin melanoma
resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1505000/full
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