Infiltration of Immunoinflammatory Cells and Related Chemokine/Interleukin Expression in Different Gastric Immune Microenvironments
Gastric mucosal immune microenvironment plays an important role in the occurrence and development of diseases such as inflammation and cancer. In the present study, single-sample gene set enrichment analysis (ssGSEA) was used to evaluate the expression of cytokines and the degree of immune cell infi...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/2450569 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849403289105334272 |
|---|---|
| author | Ang Wang Siru Nie Zhi Lv Jing Wen Yuan Yuan |
| author_facet | Ang Wang Siru Nie Zhi Lv Jing Wen Yuan Yuan |
| author_sort | Ang Wang |
| collection | DOAJ |
| description | Gastric mucosal immune microenvironment plays an important role in the occurrence and development of diseases such as inflammation and cancer. In the present study, single-sample gene set enrichment analysis (ssGSEA) was used to evaluate the expression of cytokines and the degree of immune cell infiltration in four different gastric mucosa tissues from normal gastric mucosa, simple gastritis, and atrophic gastritis to gastric cancer. Here, we show the immune microenvironments of these four gastric mucosae were significantly different. From inflammation to gastric cancer, most immunoinflammatory cells showed a downward trend such as central memory CD4 T cell. Instead, several cells showed an upward trend such as macrophage. Additionally, we found some chemokines/interleukins were illustrated to be low expressed (or highly expressed) in precancerous stage and highly expressed (or low expressed) in postcancerous stage, which demonstrated an opposite expression characteristic in pre-/postcancerous stage. |
| format | Article |
| id | doaj-art-937eb372d06d40568e6ebbb225154187 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-937eb372d06d40568e6ebbb2251541872025-08-20T03:37:19ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/24505692450569Infiltration of Immunoinflammatory Cells and Related Chemokine/Interleukin Expression in Different Gastric Immune MicroenvironmentsAng Wang0Siru Nie1Zhi Lv2Jing Wen3Yuan Yuan4Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, Shenyang 110001, ChinaTumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, Shenyang 110001, ChinaTumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, Shenyang 110001, ChinaTumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, Shenyang 110001, ChinaTumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, Shenyang 110001, ChinaGastric mucosal immune microenvironment plays an important role in the occurrence and development of diseases such as inflammation and cancer. In the present study, single-sample gene set enrichment analysis (ssGSEA) was used to evaluate the expression of cytokines and the degree of immune cell infiltration in four different gastric mucosa tissues from normal gastric mucosa, simple gastritis, and atrophic gastritis to gastric cancer. Here, we show the immune microenvironments of these four gastric mucosae were significantly different. From inflammation to gastric cancer, most immunoinflammatory cells showed a downward trend such as central memory CD4 T cell. Instead, several cells showed an upward trend such as macrophage. Additionally, we found some chemokines/interleukins were illustrated to be low expressed (or highly expressed) in precancerous stage and highly expressed (or low expressed) in postcancerous stage, which demonstrated an opposite expression characteristic in pre-/postcancerous stage.http://dx.doi.org/10.1155/2020/2450569 |
| spellingShingle | Ang Wang Siru Nie Zhi Lv Jing Wen Yuan Yuan Infiltration of Immunoinflammatory Cells and Related Chemokine/Interleukin Expression in Different Gastric Immune Microenvironments Journal of Immunology Research |
| title | Infiltration of Immunoinflammatory Cells and Related Chemokine/Interleukin Expression in Different Gastric Immune Microenvironments |
| title_full | Infiltration of Immunoinflammatory Cells and Related Chemokine/Interleukin Expression in Different Gastric Immune Microenvironments |
| title_fullStr | Infiltration of Immunoinflammatory Cells and Related Chemokine/Interleukin Expression in Different Gastric Immune Microenvironments |
| title_full_unstemmed | Infiltration of Immunoinflammatory Cells and Related Chemokine/Interleukin Expression in Different Gastric Immune Microenvironments |
| title_short | Infiltration of Immunoinflammatory Cells and Related Chemokine/Interleukin Expression in Different Gastric Immune Microenvironments |
| title_sort | infiltration of immunoinflammatory cells and related chemokine interleukin expression in different gastric immune microenvironments |
| url | http://dx.doi.org/10.1155/2020/2450569 |
| work_keys_str_mv | AT angwang infiltrationofimmunoinflammatorycellsandrelatedchemokineinterleukinexpressionindifferentgastricimmunemicroenvironments AT sirunie infiltrationofimmunoinflammatorycellsandrelatedchemokineinterleukinexpressionindifferentgastricimmunemicroenvironments AT zhilv infiltrationofimmunoinflammatorycellsandrelatedchemokineinterleukinexpressionindifferentgastricimmunemicroenvironments AT jingwen infiltrationofimmunoinflammatorycellsandrelatedchemokineinterleukinexpressionindifferentgastricimmunemicroenvironments AT yuanyuan infiltrationofimmunoinflammatorycellsandrelatedchemokineinterleukinexpressionindifferentgastricimmunemicroenvironments |