Potential Biomarkers in Pleural Effusions: ACE1, ACE2, and KLK12 Levels
Discussion: These results indicate that ACE1 and KLK12 may serve as important biomarkers in the diagnostic evaluation of pleural effusions. In particular, the pleural fluid to serum (PF/S) ratios of ACE1 and KLK12 showed statistically significant differences between transudative and exudative groups...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
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| Series: | International Journal of Clinical Practice |
| Online Access: | http://dx.doi.org/10.1155/ijcp/4269986 |
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| Summary: | Discussion: These results indicate that ACE1 and KLK12 may serve as important biomarkers in the diagnostic evaluation of pleural effusions. In particular, the pleural fluid to serum (PF/S) ratios of ACE1 and KLK12 showed statistically significant differences between transudative and exudative groups, highlighting their potential in differentiating pleural effusion etiologies. While pleural fluid ACE2 levels alone did not show a significant difference, serum ACE2 concentrations and PF/S ACE2 ratios differed significantly, suggesting possible systemic changes. These findings underscore the importance of evaluating serum parameters alongside pleural fluid analysis as such comparisons may enhance diagnostic accuracy. However, the relatively small sample size limits the generalizability of these results, and further studies with larger cohorts are warranted to confirm these findings. |
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| ISSN: | 1742-1241 |