Structural-Functional Correlation in Non-Arteritic Acute Ischemic Optic Neuropathy
Junhan Wei,1,* Lei Zhang,1,* Haiyan Wang,1 Qianfeng Wang,2 Wei Jia,1 Ru Wang,1 Runsheng Wang,1 Zhili Cui1 1Shaanxi Eye Hospital, Xi’an People’s Hospital (Xi’an Fourth Hospital), Affiliated People’s Hospital of Northwest University, Xi’an, People’s Republic of China; Xi’an Key...
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Dove Medical Press
2025-05-01
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| author | Wei J Zhang L Wang H Wang Q Jia W Wang R Wang R Cui Z |
| author_facet | Wei J Zhang L Wang H Wang Q Jia W Wang R Wang R Cui Z |
| author_sort | Wei J |
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| description | Junhan Wei,1,* Lei Zhang,1,* Haiyan Wang,1 Qianfeng Wang,2 Wei Jia,1 Ru Wang,1 Runsheng Wang,1 Zhili Cui1 1Shaanxi Eye Hospital, Xi’an People’s Hospital (Xi’an Fourth Hospital), Affiliated People’s Hospital of Northwest University, Xi’an, People’s Republic of China; Xi’an Key Laboratory of Digital Medical Technology of Ophthalmologic Imaging, Xi’an, 710004, People’s Republic of China; 2Medical College of Optometry and Ophthalmology, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Haiyan Wang, Email haiyanwang@med.nwu.edu.cnPurpose: This study investigated the relationships between structural and functional parameters in non-arteritic ischemic optic neuropathy (NAION).Methods: This retrospective study enrolled 29 patients (58.2 ± 10.4 years old) with unilateral NAION. During the acute phase, we performed comprehensive evaluations including best-corrected visual acuity (BCVA), optical coherence tomography (OCT), optical coherence tomography angiography (OCTA), visual fields (VF), visual evoked potentials (VEP), electroretinography (ERG), and multifocal ERG (mf-ERG). At three months post-presentation, patients underwent follow-up assessments comprising visual acuity testing, perimetry, and advanced retinal imaging.Results: During the acute phase, affected eyes demonstrated increased mean retinal nerve fiber layer (RNFL) thickness, while ganglion cell-inner plexiform layer (GCIPL) thickness decreased. Both visual fields mean deviation (MD) and VEP P100 amplitude were reduced, accompanied by prolonged peak latency. We also observed decreased P1 response density in mf-ERG. Analysis revealed significant direct correlations between GCIPL parameters and electrophysiological measurements, particularly VEP P100 amplitude and mf-ERG P1 response density. Mean GCIPL thickness, VF MD, and VEP P100 amplitude showed negative correlations with baseline logMAR VA. Baseline VF MD, VEP P100 amplitude, and minimum GCIPL thickness showed negative correlations with logMAR VA at 3-month follow-up.Conclusion: Retinal ganglion cell layer thickness serves as a valuable indicator to objective evaluate optic nerve function in acute NAION patients. Decreases in both VEP amplitude and mf-ERG response density showed significant correlations with retinal ganglion cell layer thickness. Baseline visual field performance, VEP measurements, and minimum GCIPL thickness exhibited negative correlations visual acuity at 3-month follow-up.Trial Registration: Clinical Research Ethics Committee of Xi’an People’s Hospital (NO. 20220018). Registered 27 September 2022-Retrospectively registered, https://www.medicalresearch.org.cn/. Informed consent was obtained from each participant.Keywords: ischemic optic neuropathy, OCTA, OCT, visual field, visual electrophysiology |
| format | Article |
| id | doaj-art-936db1333b6849d6823a76138a221c1e |
| institution | OA Journals |
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| language | English |
| publishDate | 2025-05-01 |
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| spelling | doaj-art-936db1333b6849d6823a76138a221c1e2025-08-20T02:15:29ZengDove Medical PressEye and Brain1179-27442025-05-01Volume 17Issue 11325102643Structural-Functional Correlation in Non-Arteritic Acute Ischemic Optic NeuropathyWei J0Zhang L1Wang HWang QJia W2Wang R3Wang RCui ZShaanxi Eye HospitalShaanxi Eye HospitalOphthalmologyShaanxi Eye Hospital, Xi’an People’s Hospital (Xi’an Fourth Hospital)Junhan Wei,1,* Lei Zhang,1,* Haiyan Wang,1 Qianfeng Wang,2 Wei Jia,1 Ru Wang,1 Runsheng Wang,1 Zhili Cui1 1Shaanxi Eye Hospital, Xi’an People’s Hospital (Xi’an Fourth Hospital), Affiliated People’s Hospital of Northwest University, Xi’an, People’s Republic of China; Xi’an Key Laboratory of Digital Medical Technology of Ophthalmologic Imaging, Xi’an, 710004, People’s Republic of China; 2Medical College of Optometry and Ophthalmology, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Haiyan Wang, Email haiyanwang@med.nwu.edu.cnPurpose: This study investigated the relationships between structural and functional parameters in non-arteritic ischemic optic neuropathy (NAION).Methods: This retrospective study enrolled 29 patients (58.2 ± 10.4 years old) with unilateral NAION. During the acute phase, we performed comprehensive evaluations including best-corrected visual acuity (BCVA), optical coherence tomography (OCT), optical coherence tomography angiography (OCTA), visual fields (VF), visual evoked potentials (VEP), electroretinography (ERG), and multifocal ERG (mf-ERG). At three months post-presentation, patients underwent follow-up assessments comprising visual acuity testing, perimetry, and advanced retinal imaging.Results: During the acute phase, affected eyes demonstrated increased mean retinal nerve fiber layer (RNFL) thickness, while ganglion cell-inner plexiform layer (GCIPL) thickness decreased. Both visual fields mean deviation (MD) and VEP P100 amplitude were reduced, accompanied by prolonged peak latency. We also observed decreased P1 response density in mf-ERG. Analysis revealed significant direct correlations between GCIPL parameters and electrophysiological measurements, particularly VEP P100 amplitude and mf-ERG P1 response density. Mean GCIPL thickness, VF MD, and VEP P100 amplitude showed negative correlations with baseline logMAR VA. Baseline VF MD, VEP P100 amplitude, and minimum GCIPL thickness showed negative correlations with logMAR VA at 3-month follow-up.Conclusion: Retinal ganglion cell layer thickness serves as a valuable indicator to objective evaluate optic nerve function in acute NAION patients. Decreases in both VEP amplitude and mf-ERG response density showed significant correlations with retinal ganglion cell layer thickness. Baseline visual field performance, VEP measurements, and minimum GCIPL thickness exhibited negative correlations visual acuity at 3-month follow-up.Trial Registration: Clinical Research Ethics Committee of Xi’an People’s Hospital (NO. 20220018). Registered 27 September 2022-Retrospectively registered, https://www.medicalresearch.org.cn/. Informed consent was obtained from each participant.Keywords: ischemic optic neuropathy, OCTA, OCT, visual field, visual electrophysiologyhttps://www.dovepress.com/structural-functional-correlation-in-non-arteritic-acute-ischemic-opti-peer-reviewed-fulltext-article-EBIschemic Optic NeuropathyOCTAOCTVisual FieldVisual Electrophysiology |
| spellingShingle | Wei J Zhang L Wang H Wang Q Jia W Wang R Wang R Cui Z Structural-Functional Correlation in Non-Arteritic Acute Ischemic Optic Neuropathy Eye and Brain Ischemic Optic Neuropathy OCTA OCT Visual Field Visual Electrophysiology |
| title | Structural-Functional Correlation in Non-Arteritic Acute Ischemic Optic Neuropathy |
| title_full | Structural-Functional Correlation in Non-Arteritic Acute Ischemic Optic Neuropathy |
| title_fullStr | Structural-Functional Correlation in Non-Arteritic Acute Ischemic Optic Neuropathy |
| title_full_unstemmed | Structural-Functional Correlation in Non-Arteritic Acute Ischemic Optic Neuropathy |
| title_short | Structural-Functional Correlation in Non-Arteritic Acute Ischemic Optic Neuropathy |
| title_sort | structural functional correlation in non arteritic acute ischemic optic neuropathy |
| topic | Ischemic Optic Neuropathy OCTA OCT Visual Field Visual Electrophysiology |
| url | https://www.dovepress.com/structural-functional-correlation-in-non-arteritic-acute-ischemic-opti-peer-reviewed-fulltext-article-EB |
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