Human papillomavirus vaccination willingness and influencing factors among women in China: A systematic review and meta-analysis
Objective: This study aims to comprehensively review the human papillomavirus (HPV) vaccination willingness among Chinese women and explore the factors influencing their vaccination intentions. Methods: A comprehensive systematic search was conducted across nine electronic databases—China National K...
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Elsevier
2025-10-01
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| Series: | Preventive Medicine Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211335525002542 |
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| author | Jinghui Sun Suyun Dong Jie Gong Juan Xie Haiou Yan |
| author_facet | Jinghui Sun Suyun Dong Jie Gong Juan Xie Haiou Yan |
| author_sort | Jinghui Sun |
| collection | DOAJ |
| description | Objective: This study aims to comprehensively review the human papillomavirus (HPV) vaccination willingness among Chinese women and explore the factors influencing their vaccination intentions. Methods: A comprehensive systematic search was conducted across nine electronic databases—China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, VIP Journal Integration Service Platform, SinoMed, PubMed, Embase, Scopus, Cochrane Library, and Web of Science—from database inception to February six, 2025, to identify studies examining HPV vaccine acceptance among Chinese women. Results: The pooled willingness to receive the HPV vaccine among Chinese women was estimated at 65.7 % (95 % CI: 55.2 %–76.2 %). Subgroup analyses indicated higher intent among women with a college education or above (71.1 % versus 60.1 %), urban residents (68.3 % versus 56.0 % in rural areas), southern China residents (69.0 % versus 59.7 % in northern regions), individuals with medical-related backgrounds (84.2 % versus 35.7 %), and those with prior HPV or vaccine knowledge (66.1 %/76.4 % versus 50.2 %/57.8 %), Willingness was also higher among women with a family cancer history (74.5 % versus 55.3 %), and those impacted by COVID-19 (67.5 % versus 57.5 %). Anonymous questionnaires yielded higher willingness (71.8 % versus. 58.8 %). Other influencing factors included age, attitudes toward premarital sex, and awareness of HPV risks and vaccine benefits. Conclusions: Chinese women's overall willingness to receive the HPV vaccine remains below the World Health Organization (WHO)’s 90 % target, with significant disparities across subpopulations. Targeted public health efforts are urgently needed to enhance vaccine awareness and acceptance, especially among women in rural or underdeveloped areas, with lower education, non-medical backgrounds, or no family history of cancer. |
| format | Article |
| id | doaj-art-936af6970c4e45dbb76e188ffd2eac5d |
| institution | Kabale University |
| issn | 2211-3355 |
| language | English |
| publishDate | 2025-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Preventive Medicine Reports |
| spelling | doaj-art-936af6970c4e45dbb76e188ffd2eac5d2025-08-22T04:56:13ZengElsevierPreventive Medicine Reports2211-33552025-10-015810321510.1016/j.pmedr.2025.103215Human papillomavirus vaccination willingness and influencing factors among women in China: A systematic review and meta-analysisJinghui Sun0Suyun Dong1Jie Gong2Juan Xie3Haiou Yan4Department of Gynaecology, Affiliated Hospital of Nantong University, Nursing and Rehabilitation School of Nantong University, Nantong 226001, ChinaDepartment of Gynaecology, Affiliated Hospital of Nantong University, Nursing and Rehabilitation School of Nantong University, Nantong 226001, ChinaDepartment of Gynaecology, Affiliated Hospital of Nantong University, Nursing and Rehabilitation School of Nantong University, Nantong 226001, ChinaDepartment of Information, Affiliated Hospital of Nantong University, Nursing and Rehabilitation School of Nantong University, Nantong 226001, China; Corresponding author.Department of Nursing, Affifiliated Hospital of Nantong University, Nursing and Rehabilitation School of Nantong University, Nantong 226001, ChinaObjective: This study aims to comprehensively review the human papillomavirus (HPV) vaccination willingness among Chinese women and explore the factors influencing their vaccination intentions. Methods: A comprehensive systematic search was conducted across nine electronic databases—China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, VIP Journal Integration Service Platform, SinoMed, PubMed, Embase, Scopus, Cochrane Library, and Web of Science—from database inception to February six, 2025, to identify studies examining HPV vaccine acceptance among Chinese women. Results: The pooled willingness to receive the HPV vaccine among Chinese women was estimated at 65.7 % (95 % CI: 55.2 %–76.2 %). Subgroup analyses indicated higher intent among women with a college education or above (71.1 % versus 60.1 %), urban residents (68.3 % versus 56.0 % in rural areas), southern China residents (69.0 % versus 59.7 % in northern regions), individuals with medical-related backgrounds (84.2 % versus 35.7 %), and those with prior HPV or vaccine knowledge (66.1 %/76.4 % versus 50.2 %/57.8 %), Willingness was also higher among women with a family cancer history (74.5 % versus 55.3 %), and those impacted by COVID-19 (67.5 % versus 57.5 %). Anonymous questionnaires yielded higher willingness (71.8 % versus. 58.8 %). Other influencing factors included age, attitudes toward premarital sex, and awareness of HPV risks and vaccine benefits. Conclusions: Chinese women's overall willingness to receive the HPV vaccine remains below the World Health Organization (WHO)’s 90 % target, with significant disparities across subpopulations. Targeted public health efforts are urgently needed to enhance vaccine awareness and acceptance, especially among women in rural or underdeveloped areas, with lower education, non-medical backgrounds, or no family history of cancer.http://www.sciencedirect.com/science/article/pii/S2211335525002542WomenHuman papillomavirus vaccineChinaSystematic reviewmeta-analysis |
| spellingShingle | Jinghui Sun Suyun Dong Jie Gong Juan Xie Haiou Yan Human papillomavirus vaccination willingness and influencing factors among women in China: A systematic review and meta-analysis Preventive Medicine Reports Women Human papillomavirus vaccine China Systematic review meta-analysis |
| title | Human papillomavirus vaccination willingness and influencing factors among women in China: A systematic review and meta-analysis |
| title_full | Human papillomavirus vaccination willingness and influencing factors among women in China: A systematic review and meta-analysis |
| title_fullStr | Human papillomavirus vaccination willingness and influencing factors among women in China: A systematic review and meta-analysis |
| title_full_unstemmed | Human papillomavirus vaccination willingness and influencing factors among women in China: A systematic review and meta-analysis |
| title_short | Human papillomavirus vaccination willingness and influencing factors among women in China: A systematic review and meta-analysis |
| title_sort | human papillomavirus vaccination willingness and influencing factors among women in china a systematic review and meta analysis |
| topic | Women Human papillomavirus vaccine China Systematic review meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2211335525002542 |
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