Efficacy of single dose praziquantel against Schistosoma mansoni in East Africa: a systematic review and meta-analysis
Abstract The genus Schistosoma causes a schistosomiasis which is one of the neglected tropical diseases that pose a major threat to public health in East Africa. Praziquantel (PZQ) is the first line drug to treat human schistosomiasis. However, there is scarcity of pooled and summarized data on PZQ...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-024-84621-8 |
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| author | Miseganaw Sisay Tadesse Hailu Destaw Damtie Kindu Geta Lamesgen Zelalem Degisew Misganaw |
| author_facet | Miseganaw Sisay Tadesse Hailu Destaw Damtie Kindu Geta Lamesgen Zelalem Degisew Misganaw |
| author_sort | Miseganaw Sisay |
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| description | Abstract The genus Schistosoma causes a schistosomiasis which is one of the neglected tropical diseases that pose a major threat to public health in East Africa. Praziquantel (PZQ) is the first line drug to treat human schistosomiasis. However, there is scarcity of pooled and summarized data on PZQ efficacy to policymakers. Articles were searched from PubMed, Google Scholar, Web of Science, and Scopus databases. In total, 87 published articles were retrieved. Only studies conducted in English that reported the efficacy of PZQ against Schistosoma mansoni, regardless of the year, and studies with more than fifty positive cases were included in the present study. Excel software was used to extract the name of the authors, the total sample size, number of cured participants, the study area, and the year of publication. The pooled efficacy of PZQ against S. mansoni was analyzed using CMA Version 2.2 software. A total of 21 studies fulfilled the inclusion criteria for the present systematic review and meta-analysis. The overall pooled efficacy of PZQ was 85.0% (95% CI: 80.0-89.0%) against S. mansoni. In subgroup analysis, the efficacy of PZQ against S. mansoni was 90.4% in Ethiopia, 71.2% in Kenya, 97.9% in Rwanda, 75.4% in Tanzania, and 68.4% in Uganda. Its heterogeneity was high (I2 = 94.8), and the there is no publication bias between studies. The overall effectiveness of PZQ against S. mansoni in East Africa is doubtful. Therefore, repeated doses should be advocated. |
| format | Article |
| id | doaj-art-9366f59eb0f8400fb28125daca3806ec |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-02-01 |
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| spelling | doaj-art-9366f59eb0f8400fb28125daca3806ec2025-02-09T12:35:04ZengNature PortfolioScientific Reports2045-23222025-02-011511910.1038/s41598-024-84621-8Efficacy of single dose praziquantel against Schistosoma mansoni in East Africa: a systematic review and meta-analysisMiseganaw Sisay0Tadesse Hailu1Destaw Damtie2Kindu Geta3Lamesgen Zelalem4Degisew Misganaw5Department of Biology, College of Natural and Computational Science, Debre Tabor UniversityDepartment of Medical Laboratory Science, College of Medicine and Health Sciences, Bahir Dar UniversityDepartment of Biology, College of Science, Bahir Dar UniversityDepartment of Biology, College of Natural and Computational Science, Debre Tabor UniversityDepartment of Biology, College of Natural and Computational Science, Debre Tabor UniversityDepartment of Medical laboratory technologist, Debre Tabor Health Science CollegeAbstract The genus Schistosoma causes a schistosomiasis which is one of the neglected tropical diseases that pose a major threat to public health in East Africa. Praziquantel (PZQ) is the first line drug to treat human schistosomiasis. However, there is scarcity of pooled and summarized data on PZQ efficacy to policymakers. Articles were searched from PubMed, Google Scholar, Web of Science, and Scopus databases. In total, 87 published articles were retrieved. Only studies conducted in English that reported the efficacy of PZQ against Schistosoma mansoni, regardless of the year, and studies with more than fifty positive cases were included in the present study. Excel software was used to extract the name of the authors, the total sample size, number of cured participants, the study area, and the year of publication. The pooled efficacy of PZQ against S. mansoni was analyzed using CMA Version 2.2 software. A total of 21 studies fulfilled the inclusion criteria for the present systematic review and meta-analysis. The overall pooled efficacy of PZQ was 85.0% (95% CI: 80.0-89.0%) against S. mansoni. In subgroup analysis, the efficacy of PZQ against S. mansoni was 90.4% in Ethiopia, 71.2% in Kenya, 97.9% in Rwanda, 75.4% in Tanzania, and 68.4% in Uganda. Its heterogeneity was high (I2 = 94.8), and the there is no publication bias between studies. The overall effectiveness of PZQ against S. mansoni in East Africa is doubtful. Therefore, repeated doses should be advocated.https://doi.org/10.1038/s41598-024-84621-8Cure rateEast AfricaMeta-analysisPraziquantelSchistosoma mansoniSystematic review |
| spellingShingle | Miseganaw Sisay Tadesse Hailu Destaw Damtie Kindu Geta Lamesgen Zelalem Degisew Misganaw Efficacy of single dose praziquantel against Schistosoma mansoni in East Africa: a systematic review and meta-analysis Scientific Reports Cure rate East Africa Meta-analysis Praziquantel Schistosoma mansoni Systematic review |
| title | Efficacy of single dose praziquantel against Schistosoma mansoni in East Africa: a systematic review and meta-analysis |
| title_full | Efficacy of single dose praziquantel against Schistosoma mansoni in East Africa: a systematic review and meta-analysis |
| title_fullStr | Efficacy of single dose praziquantel against Schistosoma mansoni in East Africa: a systematic review and meta-analysis |
| title_full_unstemmed | Efficacy of single dose praziquantel against Schistosoma mansoni in East Africa: a systematic review and meta-analysis |
| title_short | Efficacy of single dose praziquantel against Schistosoma mansoni in East Africa: a systematic review and meta-analysis |
| title_sort | efficacy of single dose praziquantel against schistosoma mansoni in east africa a systematic review and meta analysis |
| topic | Cure rate East Africa Meta-analysis Praziquantel Schistosoma mansoni Systematic review |
| url | https://doi.org/10.1038/s41598-024-84621-8 |
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