Kukoamine B regulates pyroptosis mediated by NLRP3/Caspase-1/GSDMD pathway to alleviate lipopolysaccharide-induced macrophage inflammation

Kukoamine B regulates pyroptosis mediated by NLRP3/Caspase-1/GSDMD pathway to alleviate lipopolysaccharide-induced macrophage inflammation

Objective To investigate the regulatory effect of kukoamine B (KB) on the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)/Caspase-1/gasdermin D (GSDMD) pyroptosis pathway in human monocytic leukemia THP-1 cells induced by lipopolysaccharide (LPS). Methods THP-1 cells were i...

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Bibliographic Details
Main Authors: NING Pu, KE Rui, HE Ping, YANG Shuanying
Format: Article
Language:zho
Published: Editorial Office of Journal of Guangxi Medical University 2024-07-01
Series:Guangxi Yike Daxue xuebao
Subjects:
kukoamine b
inflammasome
nlrp3/caspase-1/gsdmd pathway
pyroptosis
macrophage
Online Access:https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2024.07.010
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