Bioactive Molecules, Ethnomedicinal Uses, Toxicology, and Pharmacology of <i>Peltophorum africanum</i> Sond (Fabaceae): Systematic Review
Plants have long been used to treat serious illnesses in both humans and animals. A significant underappreciated medicinal tree, <i>Peltophorum africanum</i> Sond is utilized by many different ethnic groups to cure a wide range of illnesses. A variety of electronic databases, including S...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Plants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2223-7747/14/2/239 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832587657559932928 |
|---|---|
| author | Nkoana I. Mongalo Maropeng V. Raletsena |
| author_facet | Nkoana I. Mongalo Maropeng V. Raletsena |
| author_sort | Nkoana I. Mongalo |
| collection | DOAJ |
| description | Plants have long been used to treat serious illnesses in both humans and animals. A significant underappreciated medicinal tree, <i>Peltophorum africanum</i> Sond is utilized by many different ethnic groups to cure a wide range of illnesses. A variety of electronic databases, including ScienceDirect, Scopus, Scielo, Scifinder, PubMed, Web of Science, Medline, and Google Scholar, were used to search the literature on <i>P. africanum</i>, using key words such as uses, survey, pharmacology, antigonococcal, toxicity, phytochemistry and others. Further data was obtained from several scholarly theses, dissertations, and books on general plant sciences, ethnomedicine, and other pertinent ethnobotanical topics. The plant species possess very important pharmacological activities in vitro, which includes antimicrobial, anti-HIV, antioxidant, anticancer, antidiabetic, and other activities. Phytochemically, the plant possesses various classes of compounds, dominated by flavonols, which may well explain its wider range of pharmacological activities. Although the plant is promising anti-HIV activity, the mode of action and safety profiles of the plant also need to be explored as its extracts exerted some degree of mutagenicity. It is also important to further explore its ethnoveterinary use against a plethora of nematodes that infects both wild and domestic animals. Given its potent pharmacological activity, the further in vivo studies need to be explored to ascertain the comprehensive toxicology of the plant species, thereby developing possible medications. The plant species may further be elevated to a potent pharmaceutical product against plethora of infections. |
| format | Article |
| id | doaj-art-935e4e7ee80f4b38bbc01608a8a78d7d |
| institution | Kabale University |
| issn | 2223-7747 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj-art-935e4e7ee80f4b38bbc01608a8a78d7d2025-01-24T13:46:53ZengMDPI AGPlants2223-77472025-01-0114223910.3390/plants14020239Bioactive Molecules, Ethnomedicinal Uses, Toxicology, and Pharmacology of <i>Peltophorum africanum</i> Sond (Fabaceae): Systematic ReviewNkoana I. Mongalo0Maropeng V. Raletsena1College of Agriculture and Environmental Science (CAES), University of South Africa, Priva Bag X06, Florida 0710, South AfricaCollege of Agriculture and Environmental Science (CAES), University of South Africa, Priva Bag X06, Florida 0710, South AfricaPlants have long been used to treat serious illnesses in both humans and animals. A significant underappreciated medicinal tree, <i>Peltophorum africanum</i> Sond is utilized by many different ethnic groups to cure a wide range of illnesses. A variety of electronic databases, including ScienceDirect, Scopus, Scielo, Scifinder, PubMed, Web of Science, Medline, and Google Scholar, were used to search the literature on <i>P. africanum</i>, using key words such as uses, survey, pharmacology, antigonococcal, toxicity, phytochemistry and others. Further data was obtained from several scholarly theses, dissertations, and books on general plant sciences, ethnomedicine, and other pertinent ethnobotanical topics. The plant species possess very important pharmacological activities in vitro, which includes antimicrobial, anti-HIV, antioxidant, anticancer, antidiabetic, and other activities. Phytochemically, the plant possesses various classes of compounds, dominated by flavonols, which may well explain its wider range of pharmacological activities. Although the plant is promising anti-HIV activity, the mode of action and safety profiles of the plant also need to be explored as its extracts exerted some degree of mutagenicity. It is also important to further explore its ethnoveterinary use against a plethora of nematodes that infects both wild and domestic animals. Given its potent pharmacological activity, the further in vivo studies need to be explored to ascertain the comprehensive toxicology of the plant species, thereby developing possible medications. The plant species may further be elevated to a potent pharmaceutical product against plethora of infections.https://www.mdpi.com/2223-7747/14/2/239<i>Peltophorum africanum</i> Sondsexually transmitted infectionsethnoveterinaryphytochemistryantimicrobialcytotoxicity |
| spellingShingle | Nkoana I. Mongalo Maropeng V. Raletsena Bioactive Molecules, Ethnomedicinal Uses, Toxicology, and Pharmacology of <i>Peltophorum africanum</i> Sond (Fabaceae): Systematic Review Plants <i>Peltophorum africanum</i> Sond sexually transmitted infections ethnoveterinary phytochemistry antimicrobial cytotoxicity |
| title | Bioactive Molecules, Ethnomedicinal Uses, Toxicology, and Pharmacology of <i>Peltophorum africanum</i> Sond (Fabaceae): Systematic Review |
| title_full | Bioactive Molecules, Ethnomedicinal Uses, Toxicology, and Pharmacology of <i>Peltophorum africanum</i> Sond (Fabaceae): Systematic Review |
| title_fullStr | Bioactive Molecules, Ethnomedicinal Uses, Toxicology, and Pharmacology of <i>Peltophorum africanum</i> Sond (Fabaceae): Systematic Review |
| title_full_unstemmed | Bioactive Molecules, Ethnomedicinal Uses, Toxicology, and Pharmacology of <i>Peltophorum africanum</i> Sond (Fabaceae): Systematic Review |
| title_short | Bioactive Molecules, Ethnomedicinal Uses, Toxicology, and Pharmacology of <i>Peltophorum africanum</i> Sond (Fabaceae): Systematic Review |
| title_sort | bioactive molecules ethnomedicinal uses toxicology and pharmacology of i peltophorum africanum i sond fabaceae systematic review |
| topic | <i>Peltophorum africanum</i> Sond sexually transmitted infections ethnoveterinary phytochemistry antimicrobial cytotoxicity |
| url | https://www.mdpi.com/2223-7747/14/2/239 |
| work_keys_str_mv | AT nkoanaimongalo bioactivemoleculesethnomedicinalusestoxicologyandpharmacologyofipeltophorumafricanumisondfabaceaesystematicreview AT maropengvraletsena bioactivemoleculesethnomedicinalusestoxicologyandpharmacologyofipeltophorumafricanumisondfabaceaesystematicreview |