Resolving the Two “Bony” Faces of PPAR-γ
Bone loss with aging results from attenuated and unbalanced bone turnover that has been associated with a decreased number of bone forming osteoblasts, an increased number of bone resorbing osteoclasts, and an increased number of adipocytes (fat cells) in the bone marrow. Osteoblasts and adipocytes...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/PPAR/2006/27489 |
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| author | Beata Lecka-Czernik Larry J. Suva |
| author_facet | Beata Lecka-Czernik Larry J. Suva |
| author_sort | Beata Lecka-Czernik |
| collection | DOAJ |
| description | Bone loss with aging results from attenuated and unbalanced bone turnover that has been
associated with a decreased number of bone forming osteoblasts, an increased number of
bone resorbing osteoclasts, and an increased number of adipocytes (fat cells) in the bone
marrow. Osteoblasts and adipocytes are derived from marrow mesenchymal stroma/stem cells
(MSC). The milieu of intracellular and extracellular signals that controls MSC lineage
allocation is diverse. The adipocyte-specific transcription factor
peroxisome proliferator-activated receptor-gamma (PPAR-γ) acts as a critical positive
regulator of marrow adipocyte formation and as a negative regulator of osteoblast
development. In vivo, increased PPAR-γ activity leads to bone loss, similar to the bone loss
observed with aging, whereas decreased PPAR-γ activity results in increased bone mass.
Emerging evidence suggests that the pro-adipocytic and the anti-osteoblastic properties of
PPAR-γ are ligand-selective, suggesting the existence of multiple mechanisms by which
PPAR-γ controls bone mass and fat mass in bone. |
| format | Article |
| id | doaj-art-935c20c63cbf47cba9b0b46d1cc72651 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-935c20c63cbf47cba9b0b46d1cc726512025-02-03T05:59:19ZengWileyPPAR Research1687-47571687-47652006-01-01200610.1155/PPAR/2006/2748927489Resolving the Two “Bony” Faces of PPAR-γBeata Lecka-Czernik0Larry J. Suva1Department of Geriatrics, Reynolds Institute on Aging, University of Arkansas for Medical Sciences, 629 Jack Stephens Drive, Little Rock, AR 72205, USADepartment of Orthopaedic Surgery, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USABone loss with aging results from attenuated and unbalanced bone turnover that has been associated with a decreased number of bone forming osteoblasts, an increased number of bone resorbing osteoclasts, and an increased number of adipocytes (fat cells) in the bone marrow. Osteoblasts and adipocytes are derived from marrow mesenchymal stroma/stem cells (MSC). The milieu of intracellular and extracellular signals that controls MSC lineage allocation is diverse. The adipocyte-specific transcription factor peroxisome proliferator-activated receptor-gamma (PPAR-γ) acts as a critical positive regulator of marrow adipocyte formation and as a negative regulator of osteoblast development. In vivo, increased PPAR-γ activity leads to bone loss, similar to the bone loss observed with aging, whereas decreased PPAR-γ activity results in increased bone mass. Emerging evidence suggests that the pro-adipocytic and the anti-osteoblastic properties of PPAR-γ are ligand-selective, suggesting the existence of multiple mechanisms by which PPAR-γ controls bone mass and fat mass in bone.http://dx.doi.org/10.1155/PPAR/2006/27489 |
| spellingShingle | Beata Lecka-Czernik Larry J. Suva Resolving the Two “Bony” Faces of PPAR-γ PPAR Research |
| title | Resolving the Two “Bony” Faces of PPAR-γ |
| title_full | Resolving the Two “Bony” Faces of PPAR-γ |
| title_fullStr | Resolving the Two “Bony” Faces of PPAR-γ |
| title_full_unstemmed | Resolving the Two “Bony” Faces of PPAR-γ |
| title_short | Resolving the Two “Bony” Faces of PPAR-γ |
| title_sort | resolving the two bony faces of ppar γ |
| url | http://dx.doi.org/10.1155/PPAR/2006/27489 |
| work_keys_str_mv | AT beataleckaczernik resolvingthetwobonyfacesofpparg AT larryjsuva resolvingthetwobonyfacesofpparg |