Long Acting Somatostatin Analogue: Clinical Potential for Gastrointestinal Disease
Name somatostatin is found throughout the gastrointestinal tract and has a wide variety of biological actions. Nevertheless, its short biological half-life and limited stability necessitate its use via continuous parenteral infusion and, thus, limits its therapeutic usefulness The development of lon...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1989-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1989/398524 |
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| Summary: | Name somatostatin is found throughout the gastrointestinal tract
and has a wide variety of biological actions. Nevertheless, its short biological
half-life and limited stability necessitate its use via continuous parenteral infusion
and, thus, limits its therapeutic usefulness The development of long acting
somatostatin analogues have lead to a re-examination of the therapeutic usefulness
of somatostatin in gastrointestinal disease. Somatostatin analogues appear
most beneficial tn preventing symptoms associated with neuroendocrine tumours.
In addition, case controlled studies exist to demonstrate somatostatin analogue
effectiveness in treatment of gastrointestinal hemorrhage, pancreatic fistula, pancreatitis,
short bowel syndrome and dumping syndrome. |
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| ISSN: | 0835-7900 |