Matrix Metalloproteinase-7 Associated with Congestive Heart Failure in Peritoneal Dialysis Patients: A Prospective Cohort Study
Background. Matrix metalloproteinase-7 (MMP7) is markedly expressed in patients with chronic kidney disease; its expression in dialysate and role in patients undergoing peritoneal dialysis (PD) have not been well established. Methods. Participants undergoing PD from June 1st, 2015, to June 30th, 202...
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Wiley
2023-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2023/5380764 |
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| author | Zhiwen Xiao Jianwei Tian Fen Zhang Xiaohong Zhong Tingting Zhang Zhixiu Yi Yanhong Lin Cong Yang Dan Tang Nirong Gong Jun Ai |
| author_facet | Zhiwen Xiao Jianwei Tian Fen Zhang Xiaohong Zhong Tingting Zhang Zhixiu Yi Yanhong Lin Cong Yang Dan Tang Nirong Gong Jun Ai |
| author_sort | Zhiwen Xiao |
| collection | DOAJ |
| description | Background. Matrix metalloproteinase-7 (MMP7) is markedly expressed in patients with chronic kidney disease; its expression in dialysate and role in patients undergoing peritoneal dialysis (PD) have not been well established. Methods. Participants undergoing PD from June 1st, 2015, to June 30th, 2020, were involved and were followed up every 3 months for the first year and every 6 months thereafter until death, PD withdrawal, or the end of the study. Data at each follow-up point were collected and analyzed for the association with congestive heart failure (CHF), PD withdrawal, and combined endpoint. Results. A total of 283 participants were included in this study. During a median follow-up of 21 months, 20 (7%) participants died, 93 (33%) withdrew from PD, and 105 (37%) developed CHF. A significantly increased level of serum and dialysate MMP7 was observed at baseline. Dialysate MMP7 presented a good linearity with serum MMP7. Baseline serum and dialysate MMP7 levels were associated with CHF in multivariable Cox proportional hazards regression models. After categorization, participants with high baseline MMP7 levels had a higher incidence of CHF (42%), and the hazard ratios (95% confidence intervals) were 1.595 (1.023-2.488). Interestingly, participants with higher serum MMP7 levels were trended to use dialysate with higher glucose concentration. However, the ultrafiltration volumes were not significantly increased. Higher MMP7 levels were also positively associated with PD withdrawal and combined endpoint. Conclusions. The expression of MMP7 in serum and dialysate was markedly increased and was tightly associated with the risk of CHF in PD patients. This finding suggests that the measurement of MMP7 may inform strategies for managing CHF at an earlier stage. |
| format | Article |
| id | doaj-art-934af00cf8a14587853fdfe92c69be01 |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-934af00cf8a14587853fdfe92c69be012025-08-20T03:37:20ZengWileyMediators of Inflammation1466-18612023-01-01202310.1155/2023/5380764Matrix Metalloproteinase-7 Associated with Congestive Heart Failure in Peritoneal Dialysis Patients: A Prospective Cohort StudyZhiwen Xiao0Jianwei Tian1Fen Zhang2Xiaohong Zhong3Tingting Zhang4Zhixiu Yi5Yanhong Lin6Cong Yang7Dan Tang8Nirong Gong9Jun Ai10State Key Laboratory of Organ Failure ResearchState Key Laboratory of Organ Failure ResearchState Key Laboratory of Organ Failure ResearchState Key Laboratory of Organ Failure ResearchState Key Laboratory of Organ Failure ResearchState Key Laboratory of Organ Failure ResearchState Key Laboratory of Organ Failure ResearchState Key Laboratory of Organ Failure ResearchState Key Laboratory of Organ Failure ResearchState Key Laboratory of Organ Failure ResearchState Key Laboratory of Organ Failure ResearchBackground. Matrix metalloproteinase-7 (MMP7) is markedly expressed in patients with chronic kidney disease; its expression in dialysate and role in patients undergoing peritoneal dialysis (PD) have not been well established. Methods. Participants undergoing PD from June 1st, 2015, to June 30th, 2020, were involved and were followed up every 3 months for the first year and every 6 months thereafter until death, PD withdrawal, or the end of the study. Data at each follow-up point were collected and analyzed for the association with congestive heart failure (CHF), PD withdrawal, and combined endpoint. Results. A total of 283 participants were included in this study. During a median follow-up of 21 months, 20 (7%) participants died, 93 (33%) withdrew from PD, and 105 (37%) developed CHF. A significantly increased level of serum and dialysate MMP7 was observed at baseline. Dialysate MMP7 presented a good linearity with serum MMP7. Baseline serum and dialysate MMP7 levels were associated with CHF in multivariable Cox proportional hazards regression models. After categorization, participants with high baseline MMP7 levels had a higher incidence of CHF (42%), and the hazard ratios (95% confidence intervals) were 1.595 (1.023-2.488). Interestingly, participants with higher serum MMP7 levels were trended to use dialysate with higher glucose concentration. However, the ultrafiltration volumes were not significantly increased. Higher MMP7 levels were also positively associated with PD withdrawal and combined endpoint. Conclusions. The expression of MMP7 in serum and dialysate was markedly increased and was tightly associated with the risk of CHF in PD patients. This finding suggests that the measurement of MMP7 may inform strategies for managing CHF at an earlier stage.http://dx.doi.org/10.1155/2023/5380764 |
| spellingShingle | Zhiwen Xiao Jianwei Tian Fen Zhang Xiaohong Zhong Tingting Zhang Zhixiu Yi Yanhong Lin Cong Yang Dan Tang Nirong Gong Jun Ai Matrix Metalloproteinase-7 Associated with Congestive Heart Failure in Peritoneal Dialysis Patients: A Prospective Cohort Study Mediators of Inflammation |
| title | Matrix Metalloproteinase-7 Associated with Congestive Heart Failure in Peritoneal Dialysis Patients: A Prospective Cohort Study |
| title_full | Matrix Metalloproteinase-7 Associated with Congestive Heart Failure in Peritoneal Dialysis Patients: A Prospective Cohort Study |
| title_fullStr | Matrix Metalloproteinase-7 Associated with Congestive Heart Failure in Peritoneal Dialysis Patients: A Prospective Cohort Study |
| title_full_unstemmed | Matrix Metalloproteinase-7 Associated with Congestive Heart Failure in Peritoneal Dialysis Patients: A Prospective Cohort Study |
| title_short | Matrix Metalloproteinase-7 Associated with Congestive Heart Failure in Peritoneal Dialysis Patients: A Prospective Cohort Study |
| title_sort | matrix metalloproteinase 7 associated with congestive heart failure in peritoneal dialysis patients a prospective cohort study |
| url | http://dx.doi.org/10.1155/2023/5380764 |
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