Proinflammatory macrophages release CXCL5 to regulate T cell function and limit effects of αPD-1 in steatosis-driven liver cancer

Proinflammatory macrophages release CXCL5 to regulate T cell function and limit effects of αPD-1 in steatosis-driven liver cancer

Background & Aims: Steatosis is a comorbid factor for cancer development. Patients with steatosis do not respond well to current immune checkpoint therapy (CPI) treatment. We explored the roles of neutrophil-activating chemokines (NACs) in the response of steatosis/liver cancer to CPI. Metho...

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Main Authors: Taojian Tu, Handan Hong, Diala Alhousari, Lina He, Mario Alba, Yiwei Gu, Brittney Hua, Phillip Nguyen, Qi Tang, Tianyi Xia, Karam Ashouri, Anastasia Martynova, Christina Nakhoul, Whitaker Cohn, Genshu Wang, Geyang Xu, Zhang-Xu Liu, Curtis Okamoto, Enrique Cadenas, Julian Whitelegge, Weiming Yuan, Shefali Chopra, Keigo Machida, Liyun Yuan, Anthony El-Khoueiry, Bangyan L. Stiles
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:JHEP Reports
Subjects:
Fibrosis
HCC
NAFLD/NASH
PTEN
Online Access:http://www.sciencedirect.com/science/article/pii/S258955592500062X
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