Thrombospondin-1 Silencing Ameliorates Osteoblastic Differentiation of Aortic Valve Interstitial Cells via Inhibiting Nuclear Factor-κB Pathway
Conclusions: The present study has shown that TSP-1 silencing could mitigate the development of CAVD by inhibiting NF-κB-mediated inflammation. We propose that targeting TSP-1-mediated NF-κB pathway could provide a potential therapeutic method for treating CAVD.
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
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| Series: | Cardiovascular Therapeutics |
| Online Access: | http://dx.doi.org/10.1155/cdr/3845211 |
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| _version_ | 1850199917673316352 |
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| author | Qing Li Chengxiang Song Zisong Wei Junli Li Hao Zhou Shuoding Wang Hongde Li Haoran Yang Qiang Luo Mao Chen |
| author_facet | Qing Li Chengxiang Song Zisong Wei Junli Li Hao Zhou Shuoding Wang Hongde Li Haoran Yang Qiang Luo Mao Chen |
| author_sort | Qing Li |
| collection | DOAJ |
| description | Conclusions: The present study has shown that TSP-1 silencing could mitigate the development of CAVD by inhibiting NF-κB-mediated inflammation. We propose that targeting TSP-1-mediated NF-κB pathway could provide a potential therapeutic method for treating CAVD. |
| format | Article |
| id | doaj-art-934600d1fb3f43919290b7e2fd1d9e18 |
| institution | OA Journals |
| issn | 1755-5922 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiovascular Therapeutics |
| spelling | doaj-art-934600d1fb3f43919290b7e2fd1d9e182025-08-20T02:12:30ZengWileyCardiovascular Therapeutics1755-59222025-01-01202510.1155/cdr/3845211Thrombospondin-1 Silencing Ameliorates Osteoblastic Differentiation of Aortic Valve Interstitial Cells via Inhibiting Nuclear Factor-κB PathwayQing Li0Chengxiang Song1Zisong Wei2Junli Li3Hao Zhou4Shuoding Wang5Hongde Li6Haoran Yang7Qiang Luo8Mao Chen9Laboratory of Cardiac Structure and FunctionLaboratory of Cardiac Structure and FunctionLaboratory of Cardiac Structure and FunctionLaboratory of Cardiac Structure and FunctionLaboratory of Cardiac Structure and FunctionLaboratory of Cardiac Structure and FunctionLaboratory of Cardiac Structure and FunctionLaboratory of Cardiac Structure and FunctionLaboratory of Cardiac Structure and FunctionLaboratory of Cardiac Structure and FunctionConclusions: The present study has shown that TSP-1 silencing could mitigate the development of CAVD by inhibiting NF-κB-mediated inflammation. We propose that targeting TSP-1-mediated NF-κB pathway could provide a potential therapeutic method for treating CAVD.http://dx.doi.org/10.1155/cdr/3845211 |
| spellingShingle | Qing Li Chengxiang Song Zisong Wei Junli Li Hao Zhou Shuoding Wang Hongde Li Haoran Yang Qiang Luo Mao Chen Thrombospondin-1 Silencing Ameliorates Osteoblastic Differentiation of Aortic Valve Interstitial Cells via Inhibiting Nuclear Factor-κB Pathway Cardiovascular Therapeutics |
| title | Thrombospondin-1 Silencing Ameliorates Osteoblastic Differentiation of Aortic Valve Interstitial Cells via Inhibiting Nuclear Factor-κB Pathway |
| title_full | Thrombospondin-1 Silencing Ameliorates Osteoblastic Differentiation of Aortic Valve Interstitial Cells via Inhibiting Nuclear Factor-κB Pathway |
| title_fullStr | Thrombospondin-1 Silencing Ameliorates Osteoblastic Differentiation of Aortic Valve Interstitial Cells via Inhibiting Nuclear Factor-κB Pathway |
| title_full_unstemmed | Thrombospondin-1 Silencing Ameliorates Osteoblastic Differentiation of Aortic Valve Interstitial Cells via Inhibiting Nuclear Factor-κB Pathway |
| title_short | Thrombospondin-1 Silencing Ameliorates Osteoblastic Differentiation of Aortic Valve Interstitial Cells via Inhibiting Nuclear Factor-κB Pathway |
| title_sort | thrombospondin 1 silencing ameliorates osteoblastic differentiation of aortic valve interstitial cells via inhibiting nuclear factor κb pathway |
| url | http://dx.doi.org/10.1155/cdr/3845211 |
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