A senior moment: What is the program of programmed cell death?
Abstract A previously generated sequence of putative mRNA from intersegmental muscles of Manduca sexta moths just before the death of the muscles has been identified as the N-terminal sequence of a copper chaperone for superoxide dismutase. This observation suggests that prior blockage of a scavenge...
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| Format: | Article |
| Language: | English |
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BMC
2025-07-01
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| Series: | Cell Communication and Signaling |
| Online Access: | https://doi.org/10.1186/s12964-025-02255-3 |
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| _version_ | 1849402003365560320 |
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| author | Richard A. Lockshin |
| author_facet | Richard A. Lockshin |
| author_sort | Richard A. Lockshin |
| collection | DOAJ |
| description | Abstract A previously generated sequence of putative mRNA from intersegmental muscles of Manduca sexta moths just before the death of the muscles has been identified as the N-terminal sequence of a copper chaperone for superoxide dismutase. This observation suggests that prior blockage of a scavenger of free radicals may set the muscle up for free radical damage just before it begins very vigorous activity resulting in high oxygen demand. |
| format | Article |
| id | doaj-art-9342afded2884ecf87fbee6bd7e243b9 |
| institution | Kabale University |
| issn | 1478-811X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj-art-9342afded2884ecf87fbee6bd7e243b92025-08-20T03:37:38ZengBMCCell Communication and Signaling1478-811X2025-07-012311310.1186/s12964-025-02255-3A senior moment: What is the program of programmed cell death?Richard A. Lockshin0St. John’s UniversityAbstract A previously generated sequence of putative mRNA from intersegmental muscles of Manduca sexta moths just before the death of the muscles has been identified as the N-terminal sequence of a copper chaperone for superoxide dismutase. This observation suggests that prior blockage of a scavenger of free radicals may set the muscle up for free radical damage just before it begins very vigorous activity resulting in high oxygen demand.https://doi.org/10.1186/s12964-025-02255-3 |
| spellingShingle | Richard A. Lockshin A senior moment: What is the program of programmed cell death? Cell Communication and Signaling |
| title | A senior moment: What is the program of programmed cell death? |
| title_full | A senior moment: What is the program of programmed cell death? |
| title_fullStr | A senior moment: What is the program of programmed cell death? |
| title_full_unstemmed | A senior moment: What is the program of programmed cell death? |
| title_short | A senior moment: What is the program of programmed cell death? |
| title_sort | senior moment what is the program of programmed cell death |
| url | https://doi.org/10.1186/s12964-025-02255-3 |
| work_keys_str_mv | AT richardalockshin aseniormomentwhatistheprogramofprogrammedcelldeath AT richardalockshin seniormomentwhatistheprogramofprogrammedcelldeath |