A senior moment: What is the program of programmed cell death?

Abstract A previously generated sequence of putative mRNA from intersegmental muscles of Manduca sexta moths just before the death of the muscles has been identified as the N-terminal sequence of a copper chaperone for superoxide dismutase. This observation suggests that prior blockage of a scavenge...

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Bibliographic Details
Main Author: Richard A. Lockshin
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cell Communication and Signaling
Online Access:https://doi.org/10.1186/s12964-025-02255-3
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Summary:Abstract A previously generated sequence of putative mRNA from intersegmental muscles of Manduca sexta moths just before the death of the muscles has been identified as the N-terminal sequence of a copper chaperone for superoxide dismutase. This observation suggests that prior blockage of a scavenger of free radicals may set the muscle up for free radical damage just before it begins very vigorous activity resulting in high oxygen demand.
ISSN:1478-811X