Development of a breast cancer invasion score to predict tumor aggressiveness and prognosis via PI3K/AKT/mTOR pathway analysis

Abstract Invasiveness is a key indicator of tumor malignancy and is often linked to poor prognosis in breast cancer (BC). To explore the diverse characteristics of invasive cells, single-cell RNA sequencing (scRNA-seq) data from three ductal carcinoma stages were analyzed, classifying samples into i...

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Bibliographic Details
Main Authors: Xiujuan Li, Ya Zhang, Jianping Gong, Wenjia Liu, Hanchen Zhao, Wei Xue, Zhaojun Ren, Jun Bao, Ziao Lin
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02422-y
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