Noise and the risk of tinnitus: A two‐sample Mendelian randomized study
Abstract Objectives Observational studies imply that noise may increase the likelihood of developing tinnitus. However, no causal relationship has been established between the two using Mendelian randomization (MR) analysis, we aimed to determine the potential causal relationship between noise and v...
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| Format: | Article |
| Language: | English |
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Wiley
2025-06-01
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| Series: | World Journal of Otorhinolaryngology-Head and Neck Surgery |
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| Online Access: | https://doi.org/10.1002/wjo2.211 |
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| author | He‐Sen Huang Kai‐Qin Chen Wen‐Kao Zhou Bin Zhang Jing Gao Fei Xie Yu Du |
| author_facet | He‐Sen Huang Kai‐Qin Chen Wen‐Kao Zhou Bin Zhang Jing Gao Fei Xie Yu Du |
| author_sort | He‐Sen Huang |
| collection | DOAJ |
| description | Abstract Objectives Observational studies imply that noise may increase the likelihood of developing tinnitus. However, no causal relationship has been established between the two using Mendelian randomization (MR) analysis, we aimed to determine the potential causal relationship between noise and various categories of tinnitus. Methods We extracted single nucleotide polymorphisms (SNPs) associated with noise and tinnitus from a large genome‐wide association study (GWAS) of European individuals. UK Biobank (UKB) provided summary data for both entities. Inverse variance weighting (IVW) was implemented as the primary method for evaluating effect estimates. Using Weighted median and MR–Egger regression, heterogeneity and pleiotropy were evaluated using sensitivity analyses. Results The random‐effects IVW approach revealed a causal relationship between noise and the three onset tinnitus (odds ratio [OR] = 1.052, 95% confidence interval [CI] = 1.013–1.092, p = 0.008; OR = 1.248, 95% CI = 1.177–1.323, p = 0.001; OR = 1.133, 95% CI = 1.058–1.213, p = 0.001). Noise was not a risk factor for tinnitus in the past (OR = 0.999, 95% CI = 0.934–1.068, p = 0.969). Validation with various Mendelian randomization methodologies and sensitivity analyses confirmed the findings' consistency. Conclusion This Mendelian Randomization study provides causal evidence that noise is a risk factor for the onset of tinnitus but is not a risk factor for developing tinnitus in the past. |
| format | Article |
| id | doaj-art-933eb9fe10bf4346bc06d32e5b4c1866 |
| institution | OA Journals |
| issn | 2095-8811 2589-1081 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | World Journal of Otorhinolaryngology-Head and Neck Surgery |
| spelling | doaj-art-933eb9fe10bf4346bc06d32e5b4c18662025-08-20T02:07:24ZengWileyWorld Journal of Otorhinolaryngology-Head and Neck Surgery2095-88112589-10812025-06-0111218919710.1002/wjo2.211Noise and the risk of tinnitus: A two‐sample Mendelian randomized studyHe‐Sen Huang0Kai‐Qin Chen1Wen‐Kao Zhou2Bin Zhang3Jing Gao4Fei Xie5Yu Du6Department of Otolaryngology－Head and Neck Surgery Xiang'an Hospital of Xiamen University Xiamen Fujian ChinaDepartment of Neurosurgery Xiang'an Hospital of Xiamen University Xiamen Fujian ChinaDepartment of Emergency Medicine Xiang'an Hospital of Xiamen University Xiamen Fujian ChinaDepartment of Oral and Maxillo‐Facial Surgery Zhongshan Hospital of Xiamen University Xiamen Fujian ChinaDepartment of Otolaryngology－Head and Neck Surgery Xiang'an Hospital of Xiamen University Xiamen Fujian ChinaDepartment of Otolaryngology Hangzhou Red Cross Hospital Hangzhou Zhejiang ChinaDepartment of Otolaryngology－Head and Neck Surgery Xiang'an Hospital of Xiamen University Xiamen Fujian ChinaAbstract Objectives Observational studies imply that noise may increase the likelihood of developing tinnitus. However, no causal relationship has been established between the two using Mendelian randomization (MR) analysis, we aimed to determine the potential causal relationship between noise and various categories of tinnitus. Methods We extracted single nucleotide polymorphisms (SNPs) associated with noise and tinnitus from a large genome‐wide association study (GWAS) of European individuals. UK Biobank (UKB) provided summary data for both entities. Inverse variance weighting (IVW) was implemented as the primary method for evaluating effect estimates. Using Weighted median and MR–Egger regression, heterogeneity and pleiotropy were evaluated using sensitivity analyses. Results The random‐effects IVW approach revealed a causal relationship between noise and the three onset tinnitus (odds ratio [OR] = 1.052, 95% confidence interval [CI] = 1.013–1.092, p = 0.008; OR = 1.248, 95% CI = 1.177–1.323, p = 0.001; OR = 1.133, 95% CI = 1.058–1.213, p = 0.001). Noise was not a risk factor for tinnitus in the past (OR = 0.999, 95% CI = 0.934–1.068, p = 0.969). Validation with various Mendelian randomization methodologies and sensitivity analyses confirmed the findings' consistency. Conclusion This Mendelian Randomization study provides causal evidence that noise is a risk factor for the onset of tinnitus but is not a risk factor for developing tinnitus in the past.https://doi.org/10.1002/wjo2.211causal relationshipgenome‐wide association studiesMendelian randomizationnoisetinnitus |
| spellingShingle | He‐Sen Huang Kai‐Qin Chen Wen‐Kao Zhou Bin Zhang Jing Gao Fei Xie Yu Du Noise and the risk of tinnitus: A two‐sample Mendelian randomized study World Journal of Otorhinolaryngology-Head and Neck Surgery causal relationship genome‐wide association studies Mendelian randomization noise tinnitus |
| title | Noise and the risk of tinnitus: A two‐sample Mendelian randomized study |
| title_full | Noise and the risk of tinnitus: A two‐sample Mendelian randomized study |
| title_fullStr | Noise and the risk of tinnitus: A two‐sample Mendelian randomized study |
| title_full_unstemmed | Noise and the risk of tinnitus: A two‐sample Mendelian randomized study |
| title_short | Noise and the risk of tinnitus: A two‐sample Mendelian randomized study |
| title_sort | noise and the risk of tinnitus a two sample mendelian randomized study |
| topic | causal relationship genome‐wide association studies Mendelian randomization noise tinnitus |
| url | https://doi.org/10.1002/wjo2.211 |
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