Modeling historic incidence trends implies early field cancerization in esophageal squamous cell carcinoma.

Modeling historic incidence trends implies early field cancerization in esophageal squamous cell carcinoma.

Patterns of cancer incidence, viewed over extended time periods, reveal important aspects of multistage carcinogenesis. Here we show how a multistage clonal expansion (MSCE) model for cancer can be harnessed to identify biological processes that shape the surprisingly dynamic and disparate incidence...

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Bibliographic Details
Main Authors: Georg E Luebeck, Thomas L Vaughan, Kit Curtius, William D Hazelton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-05-01
Series:PLoS Computational Biology
Online Access:https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008961&type=printable
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