Induction of interleukin 21 receptor expression via enhanced intracellular metabolism in B cells and its relevance to the disease activity in systemic lupus erythematosus

Induction of interleukin 21 receptor expression via enhanced intracellular metabolism in B cells and its relevance to the disease activity in systemic lupus erythematosus

Objective To elucidate the association between the changes in intracellular metabolism in the early stage of B cell activation and systemic lupus erythematosus (SLE) pathogenesis.Methods CD19+ or CD19+CD27- (naïve) cells from the peripheral blood of healthy controls and lupus patients were cultured...

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Main Authors: Yoshiya Tanaka, Satoshi Kubo, Hiroko Miyata, Shingo Nakayamada, Kaoru Yamagata, Yusuke Miyazaki, Ippei Miyagawa, Shigeru Iwata, Ryuichiro Kanda, Koshiro Sonomoto, Yasuyuki Todoroki, Masanobu Ueno, Atsushi Nagayasu, Takafumi Aritomi
Format: Article
Language:English
Published: BMJ Publishing Group 2024-12-01
Series:RMD Open
Online Access:https://rmdopen.bmj.com/content/10/4/e004567.full
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