Tear film parameters and meibography in eyes of children with vernal keratoconjunctivitis
Purpose: To study tear film parameters and Meibomian glands in pediatric patients with vernal keratoconjunctivitis (VKC). Methods: Forty-four eyes of 22 patients with VKC and 44 eyes of 22 age-matched controls were studied in a hospital-based cross-sectional study. Each subject underwent a complete...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Indian Journal of Ophthalmology |
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| Online Access: | https://journals.lww.com/10.4103/IJO.IJO_24_24 |
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| author | Ruchi Gupta Ritu Arora Isha Gupta Parul Jain |
| author_facet | Ruchi Gupta Ritu Arora Isha Gupta Parul Jain |
| author_sort | Ruchi Gupta |
| collection | DOAJ |
| description | Purpose:
To study tear film parameters and Meibomian glands in pediatric patients with vernal keratoconjunctivitis (VKC).
Methods:
Forty-four eyes of 22 patients with VKC and 44 eyes of 22 age-matched controls were studied in a hospital-based cross-sectional study. Each subject underwent a complete ophthalmological examination including slit-lamp biomicroscopy, non-invasive break-up time (NIBUT), fluorescein break-up time (FBUT), corneal fluorescein staining, and Schirmer’s test. Non-contact meibography was performed using a Sirius topographer.
Results:
All patients had VKC grades between 1 and 3 (Bonini scale). The mean NIBUT for cases was 8.83 ± 4.02 s and in controls, it was 15 ± 2.8 s (P value < 0.001). The mean FBUT for cases was 9.41 ± 3.45 s and in controls, it was 16.7 ± 2.5 s (P value < 0.001). Schirmer’s values were 32 ± 3.1 mm in cases and 21.4 ± 4.1 mm in controls, which were significantly higher (P value < 0.001). Also, 22.72% of the cases had corneal fluorescein staining in the form of superficial punctuate keratitis, whereas none of the control groups showed corneal staining. The examination of Meibomian glands using non-contact meibography showed a mean Meibomian gland dropout in the upper lid to be 29.7 ± 14.4% in VKC cases and 10.5 ± 3.2% in controls (P value < 0.001). Meibography of the lower lid showed 25.9 ± 10.2% dropout in cases and 20.5 ± 6.1% in controls (P value = 0.004).
Conclusion:
Tear film parameters were significantly deranged in children with VKC in the active stage as compared to age-matched controls. Children with VKC also had a higher Meibomian gland dropout. |
| format | Article |
| id | doaj-art-9332678b160c4560ba4291e0344d90a6 |
| institution | Kabale University |
| issn | 0301-4738 1998-3689 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj-art-9332678b160c4560ba4291e0344d90a62025-01-07T06:27:42ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892025-01-0173111011410.4103/IJO.IJO_24_24Tear film parameters and meibography in eyes of children with vernal keratoconjunctivitisRuchi GuptaRitu AroraIsha GuptaParul JainPurpose: To study tear film parameters and Meibomian glands in pediatric patients with vernal keratoconjunctivitis (VKC). Methods: Forty-four eyes of 22 patients with VKC and 44 eyes of 22 age-matched controls were studied in a hospital-based cross-sectional study. Each subject underwent a complete ophthalmological examination including slit-lamp biomicroscopy, non-invasive break-up time (NIBUT), fluorescein break-up time (FBUT), corneal fluorescein staining, and Schirmer’s test. Non-contact meibography was performed using a Sirius topographer. Results: All patients had VKC grades between 1 and 3 (Bonini scale). The mean NIBUT for cases was 8.83 ± 4.02 s and in controls, it was 15 ± 2.8 s (P value < 0.001). The mean FBUT for cases was 9.41 ± 3.45 s and in controls, it was 16.7 ± 2.5 s (P value < 0.001). Schirmer’s values were 32 ± 3.1 mm in cases and 21.4 ± 4.1 mm in controls, which were significantly higher (P value < 0.001). Also, 22.72% of the cases had corneal fluorescein staining in the form of superficial punctuate keratitis, whereas none of the control groups showed corneal staining. The examination of Meibomian glands using non-contact meibography showed a mean Meibomian gland dropout in the upper lid to be 29.7 ± 14.4% in VKC cases and 10.5 ± 3.2% in controls (P value < 0.001). Meibography of the lower lid showed 25.9 ± 10.2% dropout in cases and 20.5 ± 6.1% in controls (P value = 0.004). Conclusion: Tear film parameters were significantly deranged in children with VKC in the active stage as compared to age-matched controls. Children with VKC also had a higher Meibomian gland dropout.https://journals.lww.com/10.4103/IJO.IJO_24_24dry eyemeibographytear filmvkc |
| spellingShingle | Ruchi Gupta Ritu Arora Isha Gupta Parul Jain Tear film parameters and meibography in eyes of children with vernal keratoconjunctivitis Indian Journal of Ophthalmology dry eye meibography tear film vkc |
| title | Tear film parameters and meibography in eyes of children with vernal keratoconjunctivitis |
| title_full | Tear film parameters and meibography in eyes of children with vernal keratoconjunctivitis |
| title_fullStr | Tear film parameters and meibography in eyes of children with vernal keratoconjunctivitis |
| title_full_unstemmed | Tear film parameters and meibography in eyes of children with vernal keratoconjunctivitis |
| title_short | Tear film parameters and meibography in eyes of children with vernal keratoconjunctivitis |
| title_sort | tear film parameters and meibography in eyes of children with vernal keratoconjunctivitis |
| topic | dry eye meibography tear film vkc |
| url | https://journals.lww.com/10.4103/IJO.IJO_24_24 |
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