DATA 5.0—Data Acquisition, Translation & Analysis—a prospective urooncological data warehouse for the 21st century

BackgroundProspective data registration is the basis of clinical oncological research. Commonly, case documentation is restricted to studies investigating a defined hypothesis. Only few institutions prospectively register all oncological patients with a reliable, sustainable and continuous follow-up...

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Main Authors: Viktoria Schütz, Christine Geisler, Mathias Rath, Sarah Böning, Thomas Treber, Albrecht Stenzinger, Alexander Brobeil, Oliver Reinhard, Anette Duensing, Stefan Duensing, Markus Hohenfellner, Magdalena Görtz
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Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Digital Health
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Online Access:https://www.frontiersin.org/articles/10.3389/fdgth.2025.1530321/full
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author Viktoria Schütz
Christine Geisler
Mathias Rath
Sarah Böning
Thomas Treber
Albrecht Stenzinger
Alexander Brobeil
Oliver Reinhard
Anette Duensing
Anette Duensing
Stefan Duensing
Stefan Duensing
Markus Hohenfellner
Magdalena Görtz
author_facet Viktoria Schütz
Christine Geisler
Mathias Rath
Sarah Böning
Thomas Treber
Albrecht Stenzinger
Alexander Brobeil
Oliver Reinhard
Anette Duensing
Anette Duensing
Stefan Duensing
Stefan Duensing
Markus Hohenfellner
Magdalena Görtz
author_sort Viktoria Schütz
collection DOAJ
description BackgroundProspective data registration is the basis of clinical oncological research. Commonly, case documentation is restricted to studies investigating a defined hypothesis. Only few institutions prospectively register all oncological patients with a reliable, sustainable and continuous follow-up infrastructure. The Department of Urology of the Heidelberg University Hospital started its prospective tumor data base in 1992. Since then, the clinical course of all oncological in-patients is continuously registered within a life-long follow-up (success rate: 93%). Associated tumor tissue is stored in the Heidelberg Biobank. In 2005, the transfer of this invaluable registry from the initial InterSystemsCache®/KRAZTUR system to a modern data warehouse was initiated. However, the transfer of existing data into a new environment proved to be technically challenging.ObjectiveTo migrate the existing data into a modern data warehouse (DATA 5.0) while maintaining data extraction functions. Additional requirements included FHIR connectivity, big data analyses and AI applications.MethodsTogether with SAP SE, DATA 5.0 was developed. Based on SAP HANA® (High Performance Analytic Appliance) it allows data registration and analysis with third party analytical tools. The project was supported by members of the SAP SE executive board and funded by the Dietmar Hopp Foundation.ResultsData Acquisition, Translation & Analysis 5.0 (DATA 5.0), a web-based tool for data registration, preservation and analysis of treatment and follow-up data, was developed to proof-of-concept stage. DATA 5.0 was then implemented into clinical practice replacing the previous system. As of today, 15,345 oncological patients and 6.7 Mio. data points are registered.ConclusionProspective long-term data was successfully migrated into DATA 5.0, allowing data preservation, flexibility and capabilities for future data sources. DATA 5.0, together with associated tumor tissue, is a lighthouse platform for oncological research, with capability for third party analytical tools, big data analysis and AI applications including training of digital twin models.
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spelling doaj-art-932e53b2d0cd4d169a891e713d5c90fd2025-08-20T02:49:44ZengFrontiers Media S.A.Frontiers in Digital Health2673-253X2025-03-01710.3389/fdgth.2025.15303211530321DATA 5.0—Data Acquisition, Translation & Analysis—a prospective urooncological data warehouse for the 21st centuryViktoria Schütz0Christine Geisler1Mathias Rath2Sarah Böning3Thomas Treber4Albrecht Stenzinger5Alexander Brobeil6Oliver Reinhard7Anette Duensing8Anette Duensing9Stefan Duensing10Stefan Duensing11Markus Hohenfellner12Magdalena Görtz13Department of Urology, University Hospital Heidelberg, Heidelberg, GermanyDepartment of Urology, University Hospital Heidelberg, Heidelberg, GermanyDepartment of Urology, University Hospital Heidelberg, Heidelberg, GermanyMolecular Urooncology, Department of Urology, University Hospital Heidelberg, Heidelberg, GermanyCenter for Digitalization and Information Technology, University Hospital Heidelberg, Heidelberg, GermanyInstitute of Pathology, University Hospital Heidelberg, Heidelberg, GermanyInstitute of Pathology, University Hospital Heidelberg, Heidelberg, GermanyCenter for Digitalization and Information Technology, University Hospital Heidelberg, Heidelberg, GermanyDepartment of Urology, University Hospital Heidelberg, Heidelberg, GermanyPrecision Oncology of Urological Malignancies, Department of Urology, University Hospital Heidelberg, Heidelberg, GermanyDepartment of Urology, University Hospital Heidelberg, Heidelberg, GermanyMolecular Urooncology, Department of Urology, University Hospital Heidelberg, Heidelberg, GermanyDepartment of Urology, University Hospital Heidelberg, Heidelberg, GermanyDepartment of Urology, University Hospital Heidelberg, Heidelberg, GermanyBackgroundProspective data registration is the basis of clinical oncological research. Commonly, case documentation is restricted to studies investigating a defined hypothesis. Only few institutions prospectively register all oncological patients with a reliable, sustainable and continuous follow-up infrastructure. The Department of Urology of the Heidelberg University Hospital started its prospective tumor data base in 1992. Since then, the clinical course of all oncological in-patients is continuously registered within a life-long follow-up (success rate: 93%). Associated tumor tissue is stored in the Heidelberg Biobank. In 2005, the transfer of this invaluable registry from the initial InterSystemsCache®/KRAZTUR system to a modern data warehouse was initiated. However, the transfer of existing data into a new environment proved to be technically challenging.ObjectiveTo migrate the existing data into a modern data warehouse (DATA 5.0) while maintaining data extraction functions. Additional requirements included FHIR connectivity, big data analyses and AI applications.MethodsTogether with SAP SE, DATA 5.0 was developed. Based on SAP HANA® (High Performance Analytic Appliance) it allows data registration and analysis with third party analytical tools. The project was supported by members of the SAP SE executive board and funded by the Dietmar Hopp Foundation.ResultsData Acquisition, Translation & Analysis 5.0 (DATA 5.0), a web-based tool for data registration, preservation and analysis of treatment and follow-up data, was developed to proof-of-concept stage. DATA 5.0 was then implemented into clinical practice replacing the previous system. As of today, 15,345 oncological patients and 6.7 Mio. data points are registered.ConclusionProspective long-term data was successfully migrated into DATA 5.0, allowing data preservation, flexibility and capabilities for future data sources. DATA 5.0, together with associated tumor tissue, is a lighthouse platform for oncological research, with capability for third party analytical tools, big data analysis and AI applications including training of digital twin models.https://www.frontiersin.org/articles/10.3389/fdgth.2025.1530321/fullmedical databasetumor databaseurological tumorsdata warehousebig data analysisindividualized cancer treatment
spellingShingle Viktoria Schütz
Christine Geisler
Mathias Rath
Sarah Böning
Thomas Treber
Albrecht Stenzinger
Alexander Brobeil
Oliver Reinhard
Anette Duensing
Anette Duensing
Stefan Duensing
Stefan Duensing
Markus Hohenfellner
Magdalena Görtz
DATA 5.0—Data Acquisition, Translation & Analysis—a prospective urooncological data warehouse for the 21st century
Frontiers in Digital Health
medical database
tumor database
urological tumors
data warehouse
big data analysis
individualized cancer treatment
title DATA 5.0—Data Acquisition, Translation & Analysis—a prospective urooncological data warehouse for the 21st century
title_full DATA 5.0—Data Acquisition, Translation & Analysis—a prospective urooncological data warehouse for the 21st century
title_fullStr DATA 5.0—Data Acquisition, Translation & Analysis—a prospective urooncological data warehouse for the 21st century
title_full_unstemmed DATA 5.0—Data Acquisition, Translation & Analysis—a prospective urooncological data warehouse for the 21st century
title_short DATA 5.0—Data Acquisition, Translation & Analysis—a prospective urooncological data warehouse for the 21st century
title_sort data 5 0 data acquisition translation analysis a prospective urooncological data warehouse for the 21st century
topic medical database
tumor database
urological tumors
data warehouse
big data analysis
individualized cancer treatment
url https://www.frontiersin.org/articles/10.3389/fdgth.2025.1530321/full
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