ROLE OF Na+, K+, 2Cl– -COTRANSPORTER AND POTASSIUM CONDUCTIVITY IN THE REALIZATION OF THE EFFECT OF CARBON MONOXIDE, IN THE SMOOTH MUSCLE OF VISCERAL ORGANS
The aim of this study was to investigate the role of the Na+, K+, 2Cl– -transport and potassium conductance, in the implementation of the effects of carbon monoxide in the SMC taenia coli and ureter of guinea pig.Materials and methods. The study was conducted by the method of double saccharose bridg...
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Siberian State Medical University (Tomsk)
2016-06-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/583 |
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| author | A. V. Skvortsov M. A. Medvedev V. B. Studnitsky I. V. Kovalev Y. A. Pogudin S. V. Gusakova O. I. Antonov J. G. Birulina |
| author_facet | A. V. Skvortsov M. A. Medvedev V. B. Studnitsky I. V. Kovalev Y. A. Pogudin S. V. Gusakova O. I. Antonov J. G. Birulina |
| author_sort | A. V. Skvortsov |
| collection | DOAJ |
| description | The aim of this study was to investigate the role of the Na+, K+, 2Cl– -transport and potassium conductance, in the implementation of the effects of carbon monoxide in the SMC taenia coli and ureter of guinea pig.Materials and methods. The study was conducted by the method of double saccharose bridge. Was studied the effects of carbon monoxide donor CORM2 in ureter and smooth muscle of guinea pig of taenia coli, in normal Krebs solution, against inhibitor-bumetanide and potassium channel blocker tetraethylammonium chloride (TEA). Studied the effects of bumetanide in normal Krebs solution and the background of TEA.Main results. CORM2 causes inhibition of contractile activity of SMC taenia coli and guinea pig ureter. Its effect is weakened by bumetanide and TEA. Bumetanide causes inhibition of contractile activity of SMC taenia coli, and its effect is weakened by TEA.Conclusions. In this way, it shows that there are tissue-specific mechanisms of interrelation effects CO and ion conductivity. |
| format | Article |
| id | doaj-art-932b1f828fa04cb79c2bf9c760aa7d78 |
| institution | DOAJ |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2016-06-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-932b1f828fa04cb79c2bf9c760aa7d782025-08-20T03:21:42ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842016-06-01152656910.20538/1682-0363-2016-2-65-69532ROLE OF Na+, K+, 2Cl– -COTRANSPORTER AND POTASSIUM CONDUCTIVITY IN THE REALIZATION OF THE EFFECT OF CARBON MONOXIDE, IN THE SMOOTH MUSCLE OF VISCERAL ORGANSA. V. Skvortsov0M. A. Medvedev1V. B. Studnitsky2I. V. Kovalev3Y. A. Pogudin4S. V. Gusakova5O. I. Antonov6J. G. Birulina7Siberian State Medical University, TomskSiberian State Medical University, TomskSiberian State Medical University, TomskSiberian State Medical University, TomskSiberian State Medical University, TomskSiberian State Medical University, TomskSiberian State Medical University, TomskSiberian State Medical University, TomskThe aim of this study was to investigate the role of the Na+, K+, 2Cl– -transport and potassium conductance, in the implementation of the effects of carbon monoxide in the SMC taenia coli and ureter of guinea pig.Materials and methods. The study was conducted by the method of double saccharose bridge. Was studied the effects of carbon monoxide donor CORM2 in ureter and smooth muscle of guinea pig of taenia coli, in normal Krebs solution, against inhibitor-bumetanide and potassium channel blocker tetraethylammonium chloride (TEA). Studied the effects of bumetanide in normal Krebs solution and the background of TEA.Main results. CORM2 causes inhibition of contractile activity of SMC taenia coli and guinea pig ureter. Its effect is weakened by bumetanide and TEA. Bumetanide causes inhibition of contractile activity of SMC taenia coli, and its effect is weakened by TEA.Conclusions. In this way, it shows that there are tissue-specific mechanisms of interrelation effects CO and ion conductivity.https://bulletin.ssmu.ru/jour/article/view/583smooth muscle cellscarbon monoxidesmooth musclepotassium conductance of the membranena+k+2cl–-cotransporter |
| spellingShingle | A. V. Skvortsov M. A. Medvedev V. B. Studnitsky I. V. Kovalev Y. A. Pogudin S. V. Gusakova O. I. Antonov J. G. Birulina ROLE OF Na+, K+, 2Cl– -COTRANSPORTER AND POTASSIUM CONDUCTIVITY IN THE REALIZATION OF THE EFFECT OF CARBON MONOXIDE, IN THE SMOOTH MUSCLE OF VISCERAL ORGANS Бюллетень сибирской медицины smooth muscle cells carbon monoxide smooth muscle potassium conductance of the membrane na+ k+ 2cl–-cotransporter |
| title | ROLE OF Na+, K+, 2Cl– -COTRANSPORTER AND POTASSIUM CONDUCTIVITY IN THE REALIZATION OF THE EFFECT OF CARBON MONOXIDE, IN THE SMOOTH MUSCLE OF VISCERAL ORGANS |
| title_full | ROLE OF Na+, K+, 2Cl– -COTRANSPORTER AND POTASSIUM CONDUCTIVITY IN THE REALIZATION OF THE EFFECT OF CARBON MONOXIDE, IN THE SMOOTH MUSCLE OF VISCERAL ORGANS |
| title_fullStr | ROLE OF Na+, K+, 2Cl– -COTRANSPORTER AND POTASSIUM CONDUCTIVITY IN THE REALIZATION OF THE EFFECT OF CARBON MONOXIDE, IN THE SMOOTH MUSCLE OF VISCERAL ORGANS |
| title_full_unstemmed | ROLE OF Na+, K+, 2Cl– -COTRANSPORTER AND POTASSIUM CONDUCTIVITY IN THE REALIZATION OF THE EFFECT OF CARBON MONOXIDE, IN THE SMOOTH MUSCLE OF VISCERAL ORGANS |
| title_short | ROLE OF Na+, K+, 2Cl– -COTRANSPORTER AND POTASSIUM CONDUCTIVITY IN THE REALIZATION OF THE EFFECT OF CARBON MONOXIDE, IN THE SMOOTH MUSCLE OF VISCERAL ORGANS |
| title_sort | role of na k 2cl cotransporter and potassium conductivity in the realization of the effect of carbon monoxide in the smooth muscle of visceral organs |
| topic | smooth muscle cells carbon monoxide smooth muscle potassium conductance of the membrane na+ k+ 2cl–-cotransporter |
| url | https://bulletin.ssmu.ru/jour/article/view/583 |
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