Mechanistic insights into resistance mechanisms to T cell engagers

Mechanistic insights into resistance mechanisms to T cell engagers

T cell engagers (TCEs) represent a groundbreaking advancement in the treatment of B and plasma cell malignancies and are emerging as a promising therapeutic approach for the treatment of solid tumors. These molecules harness T cells to bind to and eliminate cancer cells, effectively bypassing the ne...

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Bibliographic Details
Main Authors: Linlin Cao, Gabrielle Leclercq-Cohen, Christian Klein, Antonio Sorrentino, Marina Bacac
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
resistance mechanism
T cell engager
intrinsic mechanism
tumor microenvironment
T cell function
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1583044/full
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