A Role of Glucose Overload in Diabetic Cardiomyopathy in Nonhuman Primates
Type 2 diabetes (T2D) plays a major role in the development of heart failure. Patients with T2D have an increased risk to develop HF than healthy subjects, and they always have very poor outcomes and survival rates. However, the underlying mechanisms for this are still unclear. To help develop new t...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2021/9676754 |
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| _version_ | 1849403279817048064 |
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| author | Xiu Wang Shi Jin Weina Hu |
| author_facet | Xiu Wang Shi Jin Weina Hu |
| author_sort | Xiu Wang |
| collection | DOAJ |
| description | Type 2 diabetes (T2D) plays a major role in the development of heart failure. Patients with T2D have an increased risk to develop HF than healthy subjects, and they always have very poor outcomes and survival rates. However, the underlying mechanisms for this are still unclear. To help develop new therapeutic interventions, well-characterized animal models for preclinical and translational investigations in T2D and HF are urgently needed. Although studies in rodents are more often used, the research findings in rodents have often failed to be translated into humans due to the significant metabolic differences between rodents and humans. Nonhuman primates (NHPs) serve as valuable translational models between basic studies in rodent models and clinical studies in humans. NHPs can recapitulate the natural progress of these diseases in humans and study the underlying mechanism due to their genetic similarity and comparable spontaneous T2D rates to humans. In this review, we discuss the importance of using NHPs models in understanding diabetic cardiomyopathy (DCM) in humans with aspects of correlations between hyperglycemia and cardiac dysfunction progression, glucose overload, and altered glucose metabolism promoting cardiac oxidative stress and mitochondria dysfunction, glucose, and its effect on cardiac resynchronization therapy with defibrillator (CRT-d), the currently available diabetic NHPs models and the limitations involved in the use of NHP models. |
| format | Article |
| id | doaj-art-9329155e015844fb95d7fb139cf5474f |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-9329155e015844fb95d7fb139cf5474f2025-08-20T03:37:19ZengWileyJournal of Diabetes Research2314-67452314-67532021-01-01202110.1155/2021/96767549676754A Role of Glucose Overload in Diabetic Cardiomyopathy in Nonhuman PrimatesXiu Wang0Shi Jin1Weina Hu2Department of Anesthesiology, The Fourth Affiliated Hospital of China Medical University, Shenyang 110034, ChinaDepartment of Endocrinology, The Fourth Affiliated Hospital of China Medical University, Shenyang 110034, ChinaDepartment of Cardiology, The Fourth Affiliated Hospital of China Medical University, Shenyang 110034, ChinaType 2 diabetes (T2D) plays a major role in the development of heart failure. Patients with T2D have an increased risk to develop HF than healthy subjects, and they always have very poor outcomes and survival rates. However, the underlying mechanisms for this are still unclear. To help develop new therapeutic interventions, well-characterized animal models for preclinical and translational investigations in T2D and HF are urgently needed. Although studies in rodents are more often used, the research findings in rodents have often failed to be translated into humans due to the significant metabolic differences between rodents and humans. Nonhuman primates (NHPs) serve as valuable translational models between basic studies in rodent models and clinical studies in humans. NHPs can recapitulate the natural progress of these diseases in humans and study the underlying mechanism due to their genetic similarity and comparable spontaneous T2D rates to humans. In this review, we discuss the importance of using NHPs models in understanding diabetic cardiomyopathy (DCM) in humans with aspects of correlations between hyperglycemia and cardiac dysfunction progression, glucose overload, and altered glucose metabolism promoting cardiac oxidative stress and mitochondria dysfunction, glucose, and its effect on cardiac resynchronization therapy with defibrillator (CRT-d), the currently available diabetic NHPs models and the limitations involved in the use of NHP models.http://dx.doi.org/10.1155/2021/9676754 |
| spellingShingle | Xiu Wang Shi Jin Weina Hu A Role of Glucose Overload in Diabetic Cardiomyopathy in Nonhuman Primates Journal of Diabetes Research |
| title | A Role of Glucose Overload in Diabetic Cardiomyopathy in Nonhuman Primates |
| title_full | A Role of Glucose Overload in Diabetic Cardiomyopathy in Nonhuman Primates |
| title_fullStr | A Role of Glucose Overload in Diabetic Cardiomyopathy in Nonhuman Primates |
| title_full_unstemmed | A Role of Glucose Overload in Diabetic Cardiomyopathy in Nonhuman Primates |
| title_short | A Role of Glucose Overload in Diabetic Cardiomyopathy in Nonhuman Primates |
| title_sort | role of glucose overload in diabetic cardiomyopathy in nonhuman primates |
| url | http://dx.doi.org/10.1155/2021/9676754 |
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