The role of esophageal and stomach motility disorders in pathogenesis of gastroesophageal reflux disease
The aim of review. To demonstrate that esophageal and stomach motility disorders play one of basic roles in pathogenesis of gastroesophageal reflux disease (GERD).Key points. Gastroesophageal reflux disease is related to the group of acid-related diseases, however esophageal and stomach motility dis...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2015-10-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1063 |
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| author | Yu. V. Yevsyutina A. S. Trukhmanov |
| author_facet | Yu. V. Yevsyutina A. S. Trukhmanov |
| author_sort | Yu. V. Yevsyutina |
| collection | DOAJ |
| description | The aim of review. To demonstrate that esophageal and stomach motility disorders play one of basic roles in pathogenesis of gastroesophageal reflux disease (GERD).Key points. Gastroesophageal reflux disease is related to the group of acid-related diseases, however esophageal and stomach motility disorders play important role in its development. In patients with GERD disorders of primary and secondary peristalsis of the esophagus, increase of frequency of transient lower esophageal sphincter relaxations and pathologic bile refluxes are common.Conclusion. Numerous studies are devoted to investigation of gastroesophageal reflux disease. The role of motility disorders of the esophagus and the stomach in its pathogenesis, and origin of symptoms of reflux disease and other gastro-intestinal functional diseases, in particular the functional dyspepsia is actively discussed. At upper gastro-intestinal motility disorders application of prokinetics is effective, e.g. itopride hydrochloride, that reduces frequency of transient lower esophageal sphincter relaxations due to decrease of intragastric pressure, activates propulsive stomach motility and eliminates duodenogastric and duodenogastroesophageal refluxes. |
| format | Article |
| id | doaj-art-9327fd60b6b14e258ac6eb4b521513da |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2015-10-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-9327fd60b6b14e258ac6eb4b521513da2025-02-10T16:14:34ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732015-10-012551015668The role of esophageal and stomach motility disorders in pathogenesis of gastroesophageal reflux diseaseYu. V. Yevsyutina0A. S. Trukhmanov1State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university» Ministry of Healthcare of the Russian FederationState educational government-financed institution of higher professional education «Sechenov First Moscow state medical university» Ministry of Healthcare of the Russian FederationThe aim of review. To demonstrate that esophageal and stomach motility disorders play one of basic roles in pathogenesis of gastroesophageal reflux disease (GERD).Key points. Gastroesophageal reflux disease is related to the group of acid-related diseases, however esophageal and stomach motility disorders play important role in its development. In patients with GERD disorders of primary and secondary peristalsis of the esophagus, increase of frequency of transient lower esophageal sphincter relaxations and pathologic bile refluxes are common.Conclusion. Numerous studies are devoted to investigation of gastroesophageal reflux disease. The role of motility disorders of the esophagus and the stomach in its pathogenesis, and origin of symptoms of reflux disease and other gastro-intestinal functional diseases, in particular the functional dyspepsia is actively discussed. At upper gastro-intestinal motility disorders application of prokinetics is effective, e.g. itopride hydrochloride, that reduces frequency of transient lower esophageal sphincter relaxations due to decrease of intragastric pressure, activates propulsive stomach motility and eliminates duodenogastric and duodenogastroesophageal refluxes.https://www.gastro-j.ru/jour/article/view/1063gastroesophageal reflux diseasemotor disordersfunctional dyspepsiabiliary refluxprokinetics |
| spellingShingle | Yu. V. Yevsyutina A. S. Trukhmanov The role of esophageal and stomach motility disorders in pathogenesis of gastroesophageal reflux disease Российский журнал гастроэнтерологии, гепатологии, колопроктологии gastroesophageal reflux disease motor disorders functional dyspepsia biliary reflux prokinetics |
| title | The role of esophageal and stomach motility disorders in pathogenesis of gastroesophageal reflux disease |
| title_full | The role of esophageal and stomach motility disorders in pathogenesis of gastroesophageal reflux disease |
| title_fullStr | The role of esophageal and stomach motility disorders in pathogenesis of gastroesophageal reflux disease |
| title_full_unstemmed | The role of esophageal and stomach motility disorders in pathogenesis of gastroesophageal reflux disease |
| title_short | The role of esophageal and stomach motility disorders in pathogenesis of gastroesophageal reflux disease |
| title_sort | role of esophageal and stomach motility disorders in pathogenesis of gastroesophageal reflux disease |
| topic | gastroesophageal reflux disease motor disorders functional dyspepsia biliary reflux prokinetics |
| url | https://www.gastro-j.ru/jour/article/view/1063 |
| work_keys_str_mv | AT yuvyevsyutina theroleofesophagealandstomachmotilitydisordersinpathogenesisofgastroesophagealrefluxdisease AT astrukhmanov theroleofesophagealandstomachmotilitydisordersinpathogenesisofgastroesophagealrefluxdisease AT yuvyevsyutina roleofesophagealandstomachmotilitydisordersinpathogenesisofgastroesophagealrefluxdisease AT astrukhmanov roleofesophagealandstomachmotilitydisordersinpathogenesisofgastroesophagealrefluxdisease |