Hypothesis-based analysis of gene-gene interactions and risk of myocardial infarction.

Hypothesis-based analysis of gene-gene interactions and risk of myocardial infarction.

The genetic loci that have been found by genome-wide association studies to modulate risk of coronary heart disease explain only a fraction of its total variance, and gene-gene interactions have been proposed as a potential source of the remaining heritability. Given the potentially large testing bu...

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Main Authors: Gavin Lucas, Carla Lluís-Ganella, Isaac Subirana, Muntaser D Musameh, Juan Ramon Gonzalez, Christopher P Nelson, Mariano Sentí, Myocardial Infarction Genetics Consortium, Wellcome Trust Case Control Consortium, Stephen M Schwartz, David Siscovick, Christopher J O'Donnell, Olle Melander, Veikko Salomaa, Shaun Purcell, David Altshuler, Nilesh J Samani, Sekar Kathiresan, Roberto Elosua
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0041730&type=printable
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