Association of dietary intake with cancer of the digestive system: a cross-sectional study

BackgroundIn recent years, the incidence of cancers of the digestive system has been increasing, posing a severe threat to the lives and health of people around the world, and has become one of the leading causes of cancer deaths worldwide. The three most common cancers of the digestive system inclu...

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Main Authors: Xinxin Qin, Litao Ge, Song Wu, Wei Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Nutrition
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Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2025.1539401/full
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author Xinxin Qin
Litao Ge
Song Wu
Wei Li
author_facet Xinxin Qin
Litao Ge
Song Wu
Wei Li
author_sort Xinxin Qin
collection DOAJ
description BackgroundIn recent years, the incidence of cancers of the digestive system has been increasing, posing a severe threat to the lives and health of people around the world, and has become one of the leading causes of cancer deaths worldwide. The three most common cancers of the digestive system include gastric, colorectal, and liver cancers, and attention has been paid to the role of diet in the progression of these cancers. However, the relationship between dietary factors and cancers of the digestive system remains to be investigated.MethodsThis study included 30,789 adults aged 20 years or older from the National Health and Nutrition Examination Survey (NHANES), conducted from 2007 to 2018. It assessed the association between 30 dietary factors and digestive system cancers. Descriptive analysis was used to explore the demographic characteristics of the participants and p-values were calculated using a weighted linear regression model. Categorical variables were described as percentages, and p-values were calculated using weighted chi-square tests.ResultsWe found that protein, vitamin B1, calcium, and iron intake were positively associated with colorectal cancer; vitamin B2 and phosphorus intake were negatively related to colorectal cancer; dietary folate and vitamin B12 intake were negatively associated with gastric cancer; vitamin D and copper intake were positively associated with gastric cancer; vitamin E intake was negatively related to the development of hepatocellular carcinoma; and lycopene, vitamin B2, calcium, iron, and zinc intake was positively associated with the development of liver cancer. Other than that, we did not observe any correlation between other dietary factors and cancers of the digestive system.ConclusionDietary intake is associated with digestive system cancers, and more epidemiologic studies are needed to validate our results.
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spelling doaj-art-93247cc2ca0f41759f695adea4c055c02025-01-22T16:08:48ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011210.3389/fnut.2025.15394011539401Association of dietary intake with cancer of the digestive system: a cross-sectional studyXinxin QinLitao GeSong WuWei LiBackgroundIn recent years, the incidence of cancers of the digestive system has been increasing, posing a severe threat to the lives and health of people around the world, and has become one of the leading causes of cancer deaths worldwide. The three most common cancers of the digestive system include gastric, colorectal, and liver cancers, and attention has been paid to the role of diet in the progression of these cancers. However, the relationship between dietary factors and cancers of the digestive system remains to be investigated.MethodsThis study included 30,789 adults aged 20 years or older from the National Health and Nutrition Examination Survey (NHANES), conducted from 2007 to 2018. It assessed the association between 30 dietary factors and digestive system cancers. Descriptive analysis was used to explore the demographic characteristics of the participants and p-values were calculated using a weighted linear regression model. Categorical variables were described as percentages, and p-values were calculated using weighted chi-square tests.ResultsWe found that protein, vitamin B1, calcium, and iron intake were positively associated with colorectal cancer; vitamin B2 and phosphorus intake were negatively related to colorectal cancer; dietary folate and vitamin B12 intake were negatively associated with gastric cancer; vitamin D and copper intake were positively associated with gastric cancer; vitamin E intake was negatively related to the development of hepatocellular carcinoma; and lycopene, vitamin B2, calcium, iron, and zinc intake was positively associated with the development of liver cancer. Other than that, we did not observe any correlation between other dietary factors and cancers of the digestive system.ConclusionDietary intake is associated with digestive system cancers, and more epidemiologic studies are needed to validate our results.https://www.frontiersin.org/articles/10.3389/fnut.2025.1539401/fulldietary factorsNHANESgastric cancerliver cancercolorectal cancernutrients
spellingShingle Xinxin Qin
Litao Ge
Song Wu
Wei Li
Association of dietary intake with cancer of the digestive system: a cross-sectional study
Frontiers in Nutrition
dietary factors
NHANES
gastric cancer
liver cancer
colorectal cancer
nutrients
title Association of dietary intake with cancer of the digestive system: a cross-sectional study
title_full Association of dietary intake with cancer of the digestive system: a cross-sectional study
title_fullStr Association of dietary intake with cancer of the digestive system: a cross-sectional study
title_full_unstemmed Association of dietary intake with cancer of the digestive system: a cross-sectional study
title_short Association of dietary intake with cancer of the digestive system: a cross-sectional study
title_sort association of dietary intake with cancer of the digestive system a cross sectional study
topic dietary factors
NHANES
gastric cancer
liver cancer
colorectal cancer
nutrients
url https://www.frontiersin.org/articles/10.3389/fnut.2025.1539401/full
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AT litaoge associationofdietaryintakewithcancerofthedigestivesystemacrosssectionalstudy
AT songwu associationofdietaryintakewithcancerofthedigestivesystemacrosssectionalstudy
AT weili associationofdietaryintakewithcancerofthedigestivesystemacrosssectionalstudy