Comprehensive analysis of glycometabolism-related genes reveals PLOD2 as a prognostic biomarker and therapeutic target in gastric cancer

Comprehensive analysis of glycometabolism-related genes reveals PLOD2 as a prognostic biomarker and therapeutic target in gastric cancer

Abstract Background Gastric cancer (GC) is one of the leading causes of cancer-related mortality worldwide, with limited therapeutic options and a poor prognosis, particularly in advanced stages. Glycometabolism, a hallmark of cancer, plays a critical role in tumor progression, immune evasion, and r...

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Bibliographic Details
Main Authors: Wanchun Ye, Xiaolei Zhang, Zhongjie Tang, Yufeng Hu, Yuanliang Zheng, Yuping Yuan
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Gastroenterology
Subjects:
Gastric cancer
Glycometabolism
PLOD2
Immune evasion
PI3K/AKT/mTOR pathway
Prognostic model
Online Access:https://doi.org/10.1186/s12876-025-03878-z
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