Bismuth sulfide-titania heterostructure used for photothermal amplified sonodynamic therapy against hypoxic tumor

Bismuth sulfide-titania heterostructure used for photothermal amplified sonodynamic therapy against hypoxic tumor

Hypoxia and electron-hole recombination are two obstacles limiting sonodynamic therapeutic efficacy against cancer. Herein, bismuth sulfide (Bi2S3)-titania (TiO2) heterostructure is designed based on the excellent photothermal property of Bi2S3, which could improve intratumor oxygen content through...

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Bibliographic Details
Main Authors: Rui Chen, Zhiqi Yang, Yining Chen, Jinjie Wang, Yuhang Wang, Liqi Wei, Pengcheng Yu, Mengyuan Zhang, Yan Yan, Shuo Yang, Lili Wang, Yan Cheng
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Materials Today Bio
Subjects:
Sonodynamic therapy
Photothermal therapy
Hypoxia
Heterostructure
Online Access:http://www.sciencedirect.com/science/article/pii/S259000642500688X
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Summary:Hypoxia and electron-hole recombination are two obstacles limiting sonodynamic therapeutic efficacy against cancer. Herein, bismuth sulfide (Bi2S3)-titania (TiO2) heterostructure is designed based on the excellent photothermal property of Bi2S3, which could improve intratumor oxygen content through increasing blood flow with the help of near infrared light. Bi2S3-TiO2 heterostructure nanoparticles (NPs) present similar photothermal performance to Bi2S3 NPs, while Bi2S3-TiO2 NPs show higher reactive oxygen species (ROS) generating ability than Bi2S3 NPs under ultrasonic irradiation. In vitro assessments proved that Bi2S3-TiO2 NPs could produce heat and ROS to damage mitochondrial, leading to cell death due to their synergetic photothermal and sonodynamic performances. After being administrated into tumor, Bi2S3-TiO2 NPs can effectively improve oxygen content at 8 h post 808 nm laser irradiation. The tumor growth inhibition rate of Bi2S3-TiO2 NPs with 808 nm laser or ultrasound irradiation is 77.49 ± 3.96 % and 63.64 ± 2.2.7 %, respectively, while it reaches up 88.82 ± 3.98 % when 808 nm laser and ultrasound are applied in sequence, proving the photothermal amplified sonodynamic therapeutic efficacy against hypoxic tumor. As a result, the design of Bi2S3-TiO2 heterostructure NPs realizes photothermal amplified sonodynamic therapy, providing a potential strategy for treating hypoxic tumors.
ISSN:2590-0064

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