Association of walking cadence to changes in knee pain and physical function: The multicenter osteoarthritis study
Objective: Determine the association of walking cadence to incident and worsening knee pain and physical function over 2 years in adults with or at risk for knee OA. Design: Participants from the Multicenter Osteoarthritis study were included.Cadence was measured using a GAITRite walkway. Incident a...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Osteoarthritis and Cartilage Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665913125000111 |
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| author | Khara A. James Tuhina Neogi David T. Felson Patrick Corrigan Cara L. Lewis Irene S. Davis Kathryn L. Bacon James C. Torner Cora E. Lewis Michael C. Nevitt Joshua J. Stefanik |
| author_facet | Khara A. James Tuhina Neogi David T. Felson Patrick Corrigan Cara L. Lewis Irene S. Davis Kathryn L. Bacon James C. Torner Cora E. Lewis Michael C. Nevitt Joshua J. Stefanik |
| author_sort | Khara A. James |
| collection | DOAJ |
| description | Objective: Determine the association of walking cadence to incident and worsening knee pain and physical function over 2 years in adults with or at risk for knee OA. Design: Participants from the Multicenter Osteoarthritis study were included.Cadence was measured using a GAITRite walkway. Incident and worsening knee symptoms, pain with walking, and functional limitations were assessed at baseline and 2 years later. The association of cadence to each outcome was analyzed using log binomial regression. Cadence was assessed continuously as a 10-unit change and categorically using quartiles. Analyses were adjusted for age, sex, race, BMI, presence of tibiofemoral OA, depression, and history of knee injury. Sensitivity analyses were conducted for all outcomes adjusted for gait speed and stratified by sex. Results: Among 1600 participants (60.3 % female, age 67.1 ± 7.7 years), lower cadence was not significantly associated with incident or worsening knee symptoms, pain with walking, or functional limitations. For every 10-step/min decrease in cadence, the risk of incident knee symptoms increased by 10 % (RR = 1.10, 95%CI [0.97, 1.25]), though this was not statistically significant and was attenuated after adjusting for gait speed (RR = 0.95, 95%CI [0.80, 1.12]). No significant associations were observed for incident or worsening pain with walking or functional limitations. Sex-stratified analyses revealed inconsistent findings, including an increased risk for incident functional limitations in females (RR = 1.45, 95%CI [1.02, 2.08]), which was attenuated after adjusting for gait speed. Conclusion: Lower cadence was not significantly associated with pain and function, suggesting that the interplay between cadence, gait speed, and clinical outcomes warrants further investigation. |
| format | Article |
| id | doaj-art-931489d871724a04be7a099852553c7e |
| institution | Kabale University |
| issn | 2665-9131 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Osteoarthritis and Cartilage Open |
| spelling | doaj-art-931489d871724a04be7a099852553c7e2025-02-10T04:34:54ZengElsevierOsteoarthritis and Cartilage Open2665-91312025-03-0171100575Association of walking cadence to changes in knee pain and physical function: The multicenter osteoarthritis studyKhara A. James0Tuhina Neogi1David T. Felson2Patrick Corrigan3Cara L. Lewis4Irene S. Davis5Kathryn L. Bacon6James C. Torner7Cora E. Lewis8Michael C. Nevitt9Joshua J. Stefanik10Northeastern University, Boston, MA, USA; Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham and Women's Hospital, Boston, MA, USABoston University Chobanian & Avedisian School of Medicine, Section of Rheumatology, Boston, MA, USABoston University Chobanian & Avedisian School of Medicine, Section of Rheumatology, Boston, MA, USACleveland Clinic, Cleveland, OH, USABoston University Chobanian & Avedisian School of Medicine, Section of Rheumatology, Boston, MA, USA; Sargent College of Health & Rehabilitation Sciences, Boston University, Boston, MA, USAMorsani College of Medicine, University of South Florida, Tampa, FL, USABoston University Chobanian & Avedisian School of Medicine, Section of Rheumatology, Boston, MA, USAUniversity of Iowa, Iowa City, IO, USAUniversity of Alabama at Birmingham, Birmingham, AL, USAUniversity of California, San Francisco, CA, USANortheastern University, Boston, MA, USA; Boston University Chobanian & Avedisian School of Medicine, Section of Rheumatology, Boston, MA, USA; Corresponding author. Northeastern University, Department of Physical Therapy, Movement & Rehabilitation Sciences 360 Huntington Ave 457, Richards Hall, Boston, MA, 02115, USA.Objective: Determine the association of walking cadence to incident and worsening knee pain and physical function over 2 years in adults with or at risk for knee OA. Design: Participants from the Multicenter Osteoarthritis study were included.Cadence was measured using a GAITRite walkway. Incident and worsening knee symptoms, pain with walking, and functional limitations were assessed at baseline and 2 years later. The association of cadence to each outcome was analyzed using log binomial regression. Cadence was assessed continuously as a 10-unit change and categorically using quartiles. Analyses were adjusted for age, sex, race, BMI, presence of tibiofemoral OA, depression, and history of knee injury. Sensitivity analyses were conducted for all outcomes adjusted for gait speed and stratified by sex. Results: Among 1600 participants (60.3 % female, age 67.1 ± 7.7 years), lower cadence was not significantly associated with incident or worsening knee symptoms, pain with walking, or functional limitations. For every 10-step/min decrease in cadence, the risk of incident knee symptoms increased by 10 % (RR = 1.10, 95%CI [0.97, 1.25]), though this was not statistically significant and was attenuated after adjusting for gait speed (RR = 0.95, 95%CI [0.80, 1.12]). No significant associations were observed for incident or worsening pain with walking or functional limitations. Sex-stratified analyses revealed inconsistent findings, including an increased risk for incident functional limitations in females (RR = 1.45, 95%CI [1.02, 2.08]), which was attenuated after adjusting for gait speed. Conclusion: Lower cadence was not significantly associated with pain and function, suggesting that the interplay between cadence, gait speed, and clinical outcomes warrants further investigation.http://www.sciencedirect.com/science/article/pii/S2665913125000111CadencePainPhysical functionGait |
| spellingShingle | Khara A. James Tuhina Neogi David T. Felson Patrick Corrigan Cara L. Lewis Irene S. Davis Kathryn L. Bacon James C. Torner Cora E. Lewis Michael C. Nevitt Joshua J. Stefanik Association of walking cadence to changes in knee pain and physical function: The multicenter osteoarthritis study Osteoarthritis and Cartilage Open Cadence Pain Physical function Gait |
| title | Association of walking cadence to changes in knee pain and physical function: The multicenter osteoarthritis study |
| title_full | Association of walking cadence to changes in knee pain and physical function: The multicenter osteoarthritis study |
| title_fullStr | Association of walking cadence to changes in knee pain and physical function: The multicenter osteoarthritis study |
| title_full_unstemmed | Association of walking cadence to changes in knee pain and physical function: The multicenter osteoarthritis study |
| title_short | Association of walking cadence to changes in knee pain and physical function: The multicenter osteoarthritis study |
| title_sort | association of walking cadence to changes in knee pain and physical function the multicenter osteoarthritis study |
| topic | Cadence Pain Physical function Gait |
| url | http://www.sciencedirect.com/science/article/pii/S2665913125000111 |
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